Results 141 to 150 of about 63,053 (291)

Opioid Modulation of Recurrent Excitation in the Hippocampal Dentate Gyrus [PDF]

open access: hybrid, 2000
Gregory W. Terman   +4 more
openalex   +1 more source

Topiramate for the treatment of neonatal seizures and beyond

open access: yesEpilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source

Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro

open access: yesEpilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal surface antigens (NSAbs), AE pathophysiology is complex, and NSAbs‐independent mechanisms are likely to ...
Sara Prevosti   +14 more
wiley   +1 more source

Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network [PDF]

open access: hybrid, 2001
Marlene Bartos   +4 more
openalex   +1 more source

Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms

open access: yesEpilepsia, EarlyView.
Abstract Objective Fibroblast growth factor 12 (FGF12), a member of the fibroblast homologous factor family, plays a key role in the modulation of voltage‐gated sodium (Nav) channels. Pathogenic variants in the FGF12 gene leading to a gain‐of‐function mechanism and partial duplication encompassing the FGF12 gene leading to a loss‐of‐function mechanism ...
Jade Fauqueux   +18 more
wiley   +1 more source

Novel neuropathological observations in an adult with Dravet syndrome

open access: yesEpilepsia, EarlyView.
Abstract Dravet syndrome (DS) is a developmental and epileptic encephalopathy associated with pathogenic variants in the SCN1A gene. The neuropathological features of adult DS remain poorly understood. We report the postmortem findings of a 55‐year‐old woman with DS due to a confirmed SCN1A pathogenic variant leading to Nav1.1 loss of function ...
Danielle M. Andrade   +7 more
wiley   +1 more source

Dentate Gyrus and CA1 Ensemble Activity during Spatial Reference Frame Shifts in the Presence and Absence of Visual Input [PDF]

open access: bronze, 2001
Katalin M. Gothard   +3 more
openalex   +1 more source

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