Results 141 to 150 of about 139,984 (307)

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, EarlyView.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source

Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory

Science, 2018
Anh D. Bui, Theresa M. Nguyen, C. Limouse, Hannah K. Kim, Gergely G. Szabo, Sylwia Felong, Mattia Maroso, I. Soltesz   +7 more
semanticscholar   +1 more source

Dysregulation of Rho‐Associated Coiled‐Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury

Cell Proliferation, EarlyView.
Following TBI, hippocampal neurogenesis in mice is impaired and affects cognitive function. This impairment is associated with the upregulation of p‐AKT/AKT mediated by ROCK1. ABSTRACT Traumatic brain injury (TBI) represents a global health burden, often resulting in persistent neurological deficits due to impaired hippocampal neurogenesis ...
Chaoqun Yao, Long Jin, Jun Zhong, Qianying Huang, Zhongwei Bao, Shaolong Zhou, Chaohua Wang, Huanhuan Li, Xiaowei Yuan, Zhen Wang, Ning Du, Jingxuan Yu, Huanran Chen, Xuyang Zhang, Hongfei Ge, Jianheng Wu   +15 more
wiley   +1 more source

Expression of c‐fos in hilar mossy cells of the dentate gyrus in vivo

, 2013
Áine Duffy, Michael J. Schaner, Jeannie Chin, Helen E. Scharfman   +3 more
openalex   +2 more sources

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Litter size, age-related memory impairments, and microglial changes in rat dentate gyrus: Stereological analysis and three dimensional morphometry

, 2013
Lane Coelho Viana, Camila Mendes de Lima, Marcus Augusto‐Oliveira, Rubilene Pinheiro Borges, Tiago Cardoso, Izabela Almeida, Daniel Guerreiro Diniz, João Bento‐Torres, Antônio Pereira, Manuella Batista‐de‐Oliveira, Allan Lopes, Rosângela Figueiredo Mendes-da-Silva, Ricardo Abadie‐Guedes, Ângela Amâncio dos Santos, Denise Sandrelly Cavalcanti de Lima, Pedro Fernando da Costa Vasconcelos, Colm Cunningham, Rubem Carlos Araújo Guedes, Cristovam Wanderley Picanço Diniz   +18 more
openalex   +2 more sources

Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate

Epilepsia, EarlyView.
Abstract Objective Mesial temporal lobe epilepsy (MTLE) is generally associated with cognitive and psychiatric comorbidities. Here we examined whether similar comorbidities are observed in mice injected with kainate in the dorsal hippocampus, a model known to recapitulate many features of human MTLE, and if these comorbidities are sex dependent ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Philippe Kahane, Antoine Depaulis   +4 more
wiley   +1 more source

Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation [PDF]

, 2016
Yasuhito Watanabe, Michaela Müller, Jakob von Engelhardt, Rolf Sprengel, Peter H. Seeburg, Hannah Monyer   +5 more
openalex   +1 more source

Topiramate for the treatment of neonatal seizures and beyond

Epilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source

Peripheral blood mononuclear cell secretome from patients with autoimmune encephalitis promotes seizures in vitro

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis (AE) is characterized by inflammatory processes in the central nervous system and frequently presents with seizures. Even though an ictogenic potential has been shown for some antibodies against neuronal surface antigens (NSAbs), AE pathophysiology is complex, and NSAbs‐independent mechanisms are likely to ...
Sara Prevosti, Alessio Passalacqua, Maria Cristina Regondi, Giada D'Ambrosio, Alessandra Morano, Michele Romoli, Giulia Maira, Flavio Villani, Pietro Mattioli, Diego Franciotta, Andrea Stabile, Marco de Curtis, Matteo Gastaldi, Francesco Deleo, Laura Librizzi   +14 more
wiley   +1 more source