Results 61 to 70 of about 131,553 (328)

Adult-born neurons add flexibility to hippocampal memories

Frontiers in Neuroscience, 2023
Although most neurons are generated embryonically, neurogenesis is maintained at low rates in specific brain areas throughout adulthood, including the dentate gyrus of the mammalian hippocampus.
Orsolya Fölsz, Orsolya Fölsz, Stéphanie Trouche, Vincent Croset   +3 more
doaj   +1 more source

Neuroprotective efficacy of P7C3 compounds in primate hippocampus. [PDF]

, 2018
There is a critical need for translating basic science discoveries into new therapeutics for patients suffering from difficult to treat neuropsychiatric and neurodegenerative conditions.
Bauman, Melissa D, Carlson, Erin L, Cintrón-Pérez, Coral J, Pieper, Andrew A, Schumann, Cynthia M, Shin, Min-Kyoo, Taylor, Sandra L, Vázquez-Rosa, Edwin, Williams, Noelle S   +8 more
core   +2 more sources

Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit [PDF]

Frontiers in Synaptic Neuroscience, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit.
Prince, Luke, Bacon, Travis J, Tigaret, Cezar, Mellor, Jack   +3 more
openaire   +6 more sources

Choroid Plexus Fibroblast–ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury

Advanced Science, EarlyView.
This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao, Xiaoming Guo, Sixuan Tian, Huaping Huang, Caidi Ying, Junjie Wang, Jiahao Zhang, Jun Lin, Anwen Shao, Jingyu Wang, Yuan Hong   +10 more
wiley   +1 more source

Expression of the AMPA receptor subunits GluR1 and GluR2 is associated with granule cell maturation in the dentate gyrus

Frontiers in Neuroscience, 2011
The dentate gyrus produces new granule neurons throughout adulthood in mammals from rodents to humans. During granule cell maturation, defined markers are expressed in a highly regulated sequential process, which is necessary for directed neuronal ...
Hideo eHagihara, Hideo eHagihara, Koji eOhira, Koji eOhira, Keiko eToyama, Keiko eToyama, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa   +9 more
doaj   +1 more source

Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus. [PDF]

PLoS ONE, 2012
Cognitive decline during aging is correlated with a continuous loss of cells within the brain and especially within the hippocampus, which could be regenerated by adult neurogenesis.
Yvonne Imielski, Jens C Schwamborn, Patrick Lüningschrör, Peter Heimann, Magdalena Holzberg, Hendrikje Werner, Oliver Leske, Andreas W Püschel, Sylvie Memet, Rolf Heumann, Alain Israel, Christian Kaltschmidt, Barbara Kaltschmidt   +12 more
doaj   +1 more source

Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement

eLife, 2023
Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, little is known ...
Elijah A Petter, Isabella P Fallon, Ryan N Hughes, Glenn DR Watson, Warren H Meck, Francesco Paolo Ulloa Severino, Henry H Yin   +6 more
doaj   +1 more source

The N-methyl-d-aspartate receptor antagonist CPP alters synapse and spine structure and impairs long-term potentiation and long-term depression induced morphological plasticity in dentate gyrus of the awake rat [PDF]

, 2010
Long-term morphological synaptic changes associated with homosynaptic long-term potentiation (LTP) and heterosynaptic long-term depression (LTD) in vivo, in awake adult rats were analyzed using three-dimensional (3-D) reconstructions of electron ...
Abraham, Abraham, Abraham, Applegate, Bastrikova, Becker, Bourne, Bourne, Christie, De Roo, Doyère, Doyère, Engert, Fiala, Fiala, G. Dallérac, Ganeshina, Ganeshina, Garcıa-Lopez, Geinisman, Geinisman, H.A. Davies, Harris, Harris, Holtmat, I.V. Kraev, J.J. Rodriguez Arellano, Kemp, Kirov, Kosub, M.G. Stewart, Malenka, Manahan-Vaughan, Matus, Matus, Mezey, N.I. Medvedev, Nicholson, Nicholson, Nicholson, Ostroff, P.L. Gabbott, Peters, Popov, Popov, Popov, S. Laroche, Schuster, Sorra, Spacek, Spacek, Staubli, Stewart, Stewart, Tao-Cheng, Toni, Toni, V. Doyère, V.I. Popov, Wang, Yuste, Zhou   +61 more
core   +3 more sources

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Synaptic Plasticity in the Human Dentate Gyrus [PDF]

The Journal of Neuroscience, 2000
Activity-dependent plasticity is a fundamental feature of most CNS synapses and is thought to be a synaptic correlate of memory in rodents. In humans, NMDA receptors have been linked to verbal memory processes, but it is unclear whether NMDA receptor-dependent synaptic plasticity can be recruited for information storage in the human CNS.
Heinz Beck, Christian E. Elger, Ailing A. Lie, Ivan Goussakov, Christoph Helmstaedter   +4 more
openaire   +3 more sources