BMC Neuroscience, 2007 Background The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model ...
Ferraro Giuseppe, Sardo Pierangelo
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A brain-wide association study of DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia [PDF]
, 2014 The Disrupted in Schizophrenia Gene 1 (DISC1) plays a role in both neural signalling and development and is associated with schizophrenia, although its links to altered brain structure and function in this disorder are not fully established. Here we have used structural and functional MRI to investigate links with six DISC1 single nucleotide ...
arxiv +1 more source
Multi-feature concatenation and multi-classifier stacking: an interpretable and generalizable machine learning method for MDD discrimination with rsfMRI [PDF]
arXiv, 2023 Major depressive disorder is a serious and heterogeneous psychiatric disorder that needs accurate diagnosis. Resting-state functional MRI (rsfMRI), which captures multiple perspectives on brain structure, function, and connectivity, is increasingly applied in the diagnosis and pathological research of mental diseases.
arxiv
Reelin Mediates Hippocampal Cajal-Retzius Cell Positioning and Infrapyramidal Blade Morphogenesis
Journal of Developmental Biology, 2020 We have previously described hypomorphic reelin (Reln) mutant mice, RelnCTRdel, in which the morphology of the dentate gyrus is distinct from that seen in reeler mice.
Seungshin Ha +4 more
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Multimodal Integration of Olfactory and Visual Processing through DCM analysis: Contextual Modulation of Facial Perception [PDF]
arXiv, 2023 This study examines the modulatory effect of contextual hedonic olfactory stimuli on the visual processing of neutral faces using event-related potentials (ERPs) and effective connectivity analysis. The aim is to investigate how odors' valence influences the cortical connectivity underlying face processing, and the role arousal enhanced by faces plays ...
arxiv
Pattern Separation in a Spiking Neural Network of Hippocampus Robust to Imbalanced Excitation/Inhibition [PDF]
arXiv, 2018 Efficient pattern separation in dentate gyrus plays an important role in storing information in the hippocampus. Current knowledge of the structure and function of the hippocampus, entorhinal cortex and dentate gyrus, in pattern separation are incorporated in our model. A three-layer feedforward spiking neural network inspired by the rodent hippocampus
arxiv
The CA3 “backprojection” to the dentate gyrus [PDF]
, 2007 The hippocampus is typically described in the context of the trisynaptic circuit, a pathway that relays information from the perforant path to the dentate gyrus, dentate to area CA3, and CA3 to area CA1. Associated with this concept is the assumption that most hippocampal information processing occurs along the trisynaptic circuit.
openaire +3 more sources
Dentate gyrus and hilar region revisited [PDF]
Behavioral and Brain Sciences, 2016 AbstractIt is suggested that the dentate gyrus and hilar region in the hippocampus perform memory selection and that the selectivity of the gating of memory by this circuit is modulated by the norepinephrine–glutamate loop described by Mather et al.
openaire +5 more sources
Effects of anterior temporal lobe resection on cortical morphology [PDF]
arXiv, 2022 Anterior temporal lobe resection (ATLR) is a surgical procedure to treat drug-resistant temporal lobe epilepsy (TLE). Resection may involve large amounts of cortical tissue. Here, we examine the effects of this surgery on cortical morphology measured in independent variables both near the resection and remotely.
arxiv
Status Epilepticus Induced Spontaneous Dentate Gyrus Spikes: In Vivo Current Source Density Analysis. [PDF]
PLoS ONE, 2015 The dentate gyrus is considered to function as an inhibitory gate limiting excitatory input to the hippocampus. Following status epilepticus (SE), this gating function is reduced and granule cells become hyper-excitable.
Sean P Flynn +4 more
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