Results 71 to 80 of about 139,984 (307)

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Remifentanil alleviates transient cerebral ischemia-induced memory impairment through suppression of apoptotic neuronal cell death in gerbils [PDF]

Korean Journal of Anesthesiology, 2011
BackgroundDuring neurosurgical procedures, patients are often exposed to hypoxic and ischemic brain damage. Cerebral ischemia leads to neuronal cell death and eventually causes neurological impairments.
Sung-Wook Park, Jae-Woo Yi, Young-Min Kim, Jong-Man Kang, Dong Ok Kim, Mal-Soon Shin, Chang-Ju Kim, Doo Ik Lee, Dong-Hee Kim, Bong Jae Lee   +9 more
doaj   +1 more source

SpaBatch: Deep Learning‐Based Cross‐Slice Integration and 3D Spatial Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SpaBatch is an end‐to‐end multi‐slice spatial transcriptomics data integration framework. It simultaneously performs embedding learning, spatial feature denoising and reconstruction, batch effect correction, and spatial domain optimization, effectively correcting batch effects and achieving accurate 3D spatial domain identification.
Jinyun Niu, Donghai Fang, Jinyu Chen, Yi Xiong, Juan Liu, Wenwen Min   +5 more
wiley   +1 more source

Estradiol and GPER Activation Differentially Affect Cell Proliferation but Not GPER Expression in the Hippocampus of Adult Female Rats.

PLoS ONE, 2015
Estradiol increases cell proliferation in the dentate gyrus of the female rodent but it is not known whether the G protein-coupled estrogen receptor (GPER), a membrane receptor, is involved in this process, nor whether there are regional differences in ...
Paula Duarte-Guterman, Stephanie E Lieblich, Carmen Chow, Liisa A M Galea   +3 more
doaj   +1 more source

The Masticatory Activity Interference in Quantitative Estimation of CA1, CA3 and Dentate Gyrus Hippocampal Astrocytes of Aged Murine Models and under Environmental Stimulation [PDF]

, 2023
Marília da Cunha Feio Leal, Fabio Leite do Amaral, Bernardo Freire da Silva Arruda, Juliana Ayumi Azevedo Kurosawa, Amanda Almeida Vieira, Julia Maia, Viviana Virgínia Bezerra Scalfoni, Antônio Morais da Silveira, Matheus Oliveira Feijó, Fernanda Beatriz Araújo de Albuquerque, Maria Helena Moutinho Marta, Marina Paula Nobre Normando, Alana Gabriele Oliveira Cabeça da Silva, Fernanda Catharina Pires da Trindade, Fabíola de Carvalho Chaves de Siqueira Mendes, Márcia Consentino Kronka Sosthenes   +15 more
openalex   +1 more source

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

Advanced Science, EarlyView.
Piezo1 upregulates in cartilage callus during bone repair, where its deletion impairs ossification and healing in mice, while activation enhances these processes. Sirt1 positively regulates Piezo1 expression and activity to promote osteogenesis and bone repair in mice.
Donghao Gan, Yi Ran, Hong Pan, Qinnan Yan, Wenjing Zhang, Bo Zhou, Pengzhi Xu, Rongdong Liao, Haipeng Xue, Will Jiang, Tailin He, Qingyun Jia, Lei Qin, Francis Y Lee, Di Chen, Chuanju Liu, Guozhi Xiao   +16 more
wiley   +1 more source

Assessments of dentate gyrus function: discoveries and debates

Nature Reviews Neuroscience, 2023
M. Borzello, S. Ramirez, A. Treves, Inah Lee, H. Scharfman, C. Stark, J. Knierim, L. Rangel   +7 more
semanticscholar   +1 more source

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, EarlyView.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source

Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

Nature Communications
The hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context,
Thomas Hainmueller, Aurore Cazala, Li-Wen Huang, Marlene Bartos   +3 more
doaj   +1 more source

MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu, Zihao Zhu, Jiaqi Wen, Jianmei Qin, Qianshi Zheng, Weijin Yuan, Yingni Jin, Nan Lu, Lu Wang, Cheng Zhou, Tao Guo, Haoting Wu, Chenqing Wu, Ziyi Zhu, Lifang Wang, Jingwen Chen, Jingjing Wu, Bingting Zhu, Yuelin Fang, Yaping Yan, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun Xu   +23 more
wiley   +1 more source