Results 81 to 90 of about 139,984 (307)

Dentate Gyrus Proliferative Responses After Traumatic Brain Injury and Binge Alcohol in Adult Rats

Neuroscience Insights, 2020
Background: Traumatic brain injury is a significant public health issue that results in serious disability in survivors. Traumatic brain injury patients are often intoxicated with alcohol when admitted to the hospital; however, it is not clear how acute ...
Son T Ton, Natalie S Adamczyk, Jack P Gerling, Ian C Vaagenes, Joanna Y Wu, Kevin Hsu, Timothy E O’Brien, Shih-Yen Tsai, Gwendolyn L Kartje   +8 more
doaj   +1 more source

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

Advanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao, Wen‐Bo Li, Na‐Na Chen, Yang Yi, Ze‐Han Wang, Xian Chen, Yang‐Yang Zhao, Ze‐Li Yuan, Jie Gao, Yu‐Chen Pan, Dong‐Sheng Guo, Qi‐Hai Gong   +11 more
wiley   +1 more source

GABA–glutamate supramammillary neurons control theta and gamma oscillations in the dentate gyrus during paradoxical (REM) sleep [PDF]

, 2020
Francesca Billwiller, Laura Castillo, Heba Elseedy, Anton Ivanov, Jennyfer Scapula, Antoine Ghestem, Julien Carponcy, Paul‐Antoine Libourel, Hélène Bras, Nabila E. Abdelmeguid, Esther Krook-Magnuson, Iván Soltész, Christophe Bernard, Pierre‐Hervé Luppi, Monique Esclapez   +14 more
openalex   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

Advanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li, Chen Guo, Xiaoli Wu, Cuiting Wu, Songfen Wu, Si Su, Min Wu, Xidan Zhou, Si Li, Yihui Cui, Tao Zhou   +10 more
wiley   +1 more source

Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus

Stem Cell Reports, 2019
Summary: EED (embryonic ectoderm development) is a core component of the Polycomb repressive complex 2 (PRC2) which catalyzes the methylation of histone H3 lysine 27 (H3K27) during the process of self-renewal, proliferation, and differentiation of ...
Pei-Pei Liu, Ya-Jie Xu, Shang-Kun Dai, Hong-Zhen Du, Ying-Ying Wang, Xing-Guo Li, Zhao-Qian Teng, Chang-Mei Liu   +7 more
doaj   +1 more source

Usp9x-deficiency disrupts the morphological development of the postnatal hippocampal dentate gyrus

Scientific Reports, 2016
Within the adult mammalian brain, neurogenesis persists within two main discrete locations, the subventricular zone lining the lateral ventricles and the hippocampal dentate gyrus.
Sabrina Oishi, Susitha Premarathne, T. Harvey, Swati Iyer, Chantelle M Dixon, S. Alexander, T. Burne, S. Wood, M. Piper   +8 more
semanticscholar   +1 more source

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Advanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang, Yanling He, Pin Yang, Hengchang Zhang, Yueyang Tong, Lingling Jiang, Zehan Li, Meichen Yan, Xiaoheng Li, Qinghu Yang, Jing Yang, Zengqiang Yuan, Jiyan Zhang, Jinbo Cheng   +13 more
wiley   +1 more source

Object-Place Recognition Learning Triggers Rapid Induction of Plasticity-Related Immediate Early Genes and Synaptic Proteins in the Rat Dentate Gyrus

Neural Plasticity, 2008
Long-term recognition memory requires protein synthesis, but little is known about the coordinate regulation of specific genes. Here, we examined expression of the plasticity-associated immediate early genes (Arc, Zif268, and Narp) in the dentate gyrus ...
Jonathan Soulé, Zsuzsa Penke, Tambudzai Kanhema, Maria Nordheim Alme, Serge Laroche, Clive R. Bramham   +5 more
doaj   +1 more source

Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference

Journal of Neuroscience, 2015
Interference between similar or overlapping memories formed at different times poses an important challenge on the hippocampal declarative memory system.
E. Engin, E. Żarnowska, D. Benke, E. Tsvetkov, Maksim Sigal, R. Keist, V. Bolshakov, R. Pearce, U. Rudolph   +8 more
semanticscholar   +1 more source

Anatolian ground squirrel (Spermophilus xanthoprymnus) retina: Comparative expression of synaptophysin, NeuN, calbindin‐D28k, parvalbumin, glial fibrillary acidic protein, and Iba‐1 during pre‐hibernation and hibernation

The Anatomical Record, EarlyView.
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek, Feyzullah Beyaz, Mustafa Öztop, Harun Karaca, Ahmet Cabir, Begüm Fatma Kiryar   +5 more
wiley   +1 more source