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Assessment of Tumor Margin and Heterogeneity of Colorectal Cancer Using Imaging Mass Spectrometry and Image Segmentation. [PDF]
Trogrlić B +8 more
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DNA hairpin base-flipping dynamics drives APOBEC3A recognition and selectivity.
Hix MA +3 more
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Convenient syntheses of isotopically labeled pyrimidine 2'-deoxynucleosides and their 5-hydroxy oxidation products. [PDF]
Gao Y, Kool ET.
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Phosphorylation of nucleosides by P-N bond species generated from prebiotic reduced phosphorus sources. [PDF]
Gull M +3 more
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A Rapid Approach for Identifying Cell Lines Lacking Functional Cytidine Deaminase. [PDF]
Ligasová A, Kociánová M, Koberna K.
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A new deoxycytidine analog, 5-hydroxy-2′-deoxycytidine
Biochemical Medicine, 1974Abstract 5-Hydroxy-2′-deoxycytidine was synthesized as a new compound. It inhibits growth of E. coli only after deamination to 5-hydroxy-2′-deoxyuridine. 5-Hydroxy-2′-deoxycytidine is a more effective inhibitor than 5-hydroxy-2′-deoxyuridine, presumably because maintenance of an inhibitory level of the latter occurs over a longer period of time ...
K K, Leung, D W, Visser
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Deoxycytidine kinase and deoxycytidine deaminase activities in human tumour xenografts
European Journal of Cancer, 1993Deoxycytidine kinase (dCK) and deaminase (dCDA) are both key enzymes in the activation and inactivation, respectively, of several deoxycytidine antimetabolites. We determined the total dCK and dCDA activities using standard assays, in 28 human solid tumours grown as xenografts in nude mice, and four corresponding cell lines.
V W, Ruiz van Haperen +6 more
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Science, 1969
The activity of deoxycytidine aminohydrolase in the liver of various species including man was investigated. An enormously high activity was found in human liver. This fact explains the extraordinarily low level of deoxycytidine in human urine in comparison with that of other tested species.
B, Zícha, L, Buric
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The activity of deoxycytidine aminohydrolase in the liver of various species including man was investigated. An enormously high activity was found in human liver. This fact explains the extraordinarily low level of deoxycytidine in human urine in comparison with that of other tested species.
B, Zícha, L, Buric
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1998
The clinical importance of the dCTP salvage pathway is given by the fact that deoxycytidine (dCyd) analogs like cytosine arabinoside (ara-C) are activated via the salvage pathway. The non-toxic prodrug ara-C gains its cytotoxic potential by phosphorylation to the 5′-triphosphate ara-CTP. Not only cellular accumulation, but also retention of ara-CTP are
V, Heinemann +3 more
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The clinical importance of the dCTP salvage pathway is given by the fact that deoxycytidine (dCyd) analogs like cytosine arabinoside (ara-C) are activated via the salvage pathway. The non-toxic prodrug ara-C gains its cytotoxic potential by phosphorylation to the 5′-triphosphate ara-CTP. Not only cellular accumulation, but also retention of ara-CTP are
V, Heinemann +3 more
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2'-Deoxycytidine-N3-cyanoborane
Acta Crystallographica Section C Crystal Structure Communications, 1996The structure of the P2 1 2 1 2 1 form of 2'-deoxycytidineN3-cyanoborane, C 10 H 15 BN 4 O 4 , has been determined. The sugar is in the 2 E puckering mode and the C5'-05' bond has a tg conformation while the relative orientation of the sugar and the base remains anti.
Q. Gao +3 more
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