Novel PET probes specific for deoxycytidine kinase. [PDF]
J Nucl Med, 2010 Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway and a critical determinant of therapeutic activity for several nucleoside analog prodrugs. We have previously reported the development of 1-(2'-deoxy-2'-(18)F-fluoro-beta-D-arabinofuranosyl)cytosine ((18)F-FAC), a new probe for PET of dCK activity in immune ...
Shu CJ +9 more
europepmc +4 more sources
The apoptotic effects of toosendanin are partially mediated by activation of deoxycytidine kinase in HL-60 cells. [PDF]
PLoS ONE, 2012 Triterpenoid toosendanin (TSN) exhibits potent cytotoxic activity through inducing apoptosis in a variety of cancer cell lines. However, the target and mechanism of the apoptotic effects by TSN remain unknown.
Jianming Ju +7 more
doaj +2 more sources
The relation between deoxycytidine kinase activity and the radiosensitising effect of gemcitabine in eight different human tumour cell lines [PDF]
BMC Cancer, 2006 Background Gemcitabine (dFdC) is an active antitumour agent with radiosensitising properties, shown both in preclinical and clinical studies. In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect ...
Peters Godefridus J +8 more
doaj +3 more sources
Enhancing the Nucleoside Analog Response with Translational Therapeutic Approaches to Overcome Resistance [PDF]
CellsNucleoside analogs remain central to the treatment of hematologic malignancies and solid tumors, yet resistance frequently occurs, contributing to relapse and disease-related mortality.
Jenna Thibodeau +9 more
doaj +2 more sources
Urinary Metabolomic Changes and Potential Exercise-Induced Muscle Damage Biomarkers Identification in Trained Young Males Following Acute Intermittent Rowing Training [PDF]
Biosensors(1) Background: This study aims to explore the changes in urinary metabolomic profile among trained young males following acute intermittent rowing training (AIRT), and to identify potential urinary biomarkers associated with exercise-induced muscle ...
Yang Cheng +3 more
doaj +2 more sources
Clinical application and drug resistance mechanism of gemcitabine [PDF]
Frontiers in Cell and Developmental BiologyGemcitabine, as a nucleoside analog, exerts a broad-spectrum antitumor effect by interfering with DNA synthesis, but its clinical application is limited by drug resistance.
Xuanrui Zhang, Bing Qi, Jing Chen
doaj +2 more sources
Correction: Deoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer [PDF]
Cell Death and DiseaseSuman Dash +5 more
doaj +2 more sources
Scientific Reports, 2023 Deoxycytidine analogues (dCas) are widely used for the treatment of malignant diseases. They are commonly inactivated by cytidine deaminase (CDD), or by deoxycytidine monophosphate deaminase (dCMP deaminase).
Anna Ligasová +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, is tested in combination with conventional anticancer drugs as a treatment option for various solid tumors. Although epigenome modulation provides a promising avenue in treating resistant cancer
Verona Buocikova +18 more
doaj +1 more source
Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models
Experimental Hematology & Oncology, 2020 Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor response to chemo- and (modest-dose conventionally fractionated) radio-therapy. Emerging evidence suggests that pancreatic stellate cells (PSCs) secrete deoxycytidine, which confers resistance
Pei Pei Che +6 more
doaj +1 more source