Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours. [PDF]
Sci Rep, 2018 For the first time, a comprehensive human intervention study was conducted to unravel the urinary excretion profile and metabolism of the fungal metabolite deoxynivalenol (DON) and its modified form deoxynivalenol-3-glucoside (DON-3-glucoside).
Vidal A +7 more
europepmc +11 more sources
Hydrolytic fate of deoxynivalenol-3-glucoside during digestion. [PDF]
Toxicol Lett, 2011 Highlights ► Deoxynivalenol-3-glucoside (D3G) is hydrolyzed to deoxynivalenol during digestion. ► D3G is resistant to acids and enzymes expressed by humans. ► D3G is partly cleaved by cellulase and cellobiase.
Berthiller F +6 more
europepmc +5 more sources
Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs [PDF]
Toxicology Letters, 2014 Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-D-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a lack of in vivo
Franz Berthiller +2 more
exaly +5 more sources
Glucose-Dependent Insulinotropic Polypeptide and Substance P Mediate Emetic Response Induction by Masked Trichothecene Deoxynivalenol-3-Glucoside through Ca2+ Signaling. [PDF]
Toxins (Basel), 2022 Deoxynivalenol (DON), the most naturally-occurring trichothecenes, may affect animal and human health by causing vomiting as a hallmark of food poisoning. Deoxynivalenol-3-glucoside (D3G) usually co-occurs with DON as its glucosylated form and is another
Qin Z +7 more
europepmc +5 more sources
Chemical Synthesis of Deoxynivalenol-3-β-d-[13C6]-glucoside and Application in Stable Isotope Dilution Assays [PDF]
Molecules, 2016 Modified mycotoxins have been gaining importance in recent years and present a certain challenge in LC-MS/MS analysis. Due to the previous lack of a labeled isotopologue of the modified mycotoxin deoxynivalenol-3-glucoside, in our study we synthesized ...
Michael Rychlik +2 more
exaly +4 more sources
Fate of zearalenone, deoxynivalenol and deoxynivalenol-3-glucoside during malting process [PDF]
LWT - Food Science and Technology, 2019 Malting was simulated using two different batches of barley as raw material: a naturally contaminated batch and laboratory inoculated (with a deoxynivalenol (DON) and zearalenone (ZEA) producing Fusarium graminearum strain) one. Up to three contamination
Xenia Pascari +2 more
exaly +4 more sources
Enzyme bread improvers affect the stability of deoxynivalenol and deoxynivalenol-3-glucoside during breadmaking [PDF]
Food Chemistry, 2016 The stability of deoxynivalenol (DON) and deoxynivalenol-3-glucoside (DON-3-glucoside) during the breadmaking process was studied. Some enzymes used in the bakery industry were examined to evaluate their effects on DON and DON-3-glucoside.
Vicente Sanchís +2 more
exaly +5 more sources
Stability and kinetics of leaching of deoxynivalenol, deoxynivalenol-3-glucoside and ochratoxin A during boiling of wheat spaghettis [PDF]
Food Research International, 2016 The stability of deoxynivalenol (DON), deoxynivalenol-3-glucoside (DON-3-glucoside) and ochratoxin A (OTA) during spaghetti production and cooking was investigated.
Vicente Sanchís +2 more
exaly +4 more sources
The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol. [PDF]
Appl Environ Microbiol, 2013 ABSTRACT Deoxynivalenol (DON) is a potent mycotoxin produced by Fusarium molds and affects intestinal nutrient absorption and barrier function in experimental and farm animals. Free DON and the plant metabolite DON-3-β- d -glucoside (D3G) are frequently found in wheat and maize. D3G
Gratz SW, Duncan G, Richardson AJ.
europepmc +5 more sources
Transfer of Fusarium mycotoxins and ‘masked’ deoxynivalenol (deoxynivalenol-3-glucoside) from field barley through malt to beer [PDF]
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2008 The fate of five Fusarium toxins--deoxynivalenol (DON), sum of 15- and 3-acetyl-deoxynivalenol (ADONs), HT-2 toxin (HT-2) representing the main trichothecenes and zearalenone (ZON) during the malting and brewing processes--was investigated. In addition to these 'free' mycotoxins, the occurrence of deoxynivalenol-3-glucoside (DON-3-Glc) was monitored ...
Jana Hajslova, Pavel Dostalek
exaly +5 more sources