Results 111 to 120 of about 7,439 (222)

Total Synthesis and Stereochemical Assignment of Burkholdac B, a Depsipeptide HDAC Inhibitor

, 2016
Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same ...
Graham Packham (1277634), Alison M. Donlevy (2136052), A. Ganesan (434850), Hanae Benelkebir (2136049)   +3 more
core   +1 more source

Effects of additives on the prebiotic formation of depsipeptide oligomers, precursors of proto-polypeptides

, 2018
The process by which the first peptides were formed is still unclear. A few hypotheses have been proposed, but still there are doubts on whether they were possible during the prebiotic era.
Toro Arévalo, Kathyria M.
core   +1 more source

Isolation and Total Synthesis of PM170453, a New Cyclic Depsipeptide Isolated from Lyngbya sp.

Marine Drugs
In our continuing search for biologically active new chemical entities from marine organisms, we have isolated a new cyclic depsipeptide, PM170453 (1), from a cyanobacterium of the genus Lyngbya sp., collected in the Indo-Pacific Ocean.
Rogelio Fernández, Marta Pérez, Alejandro Losada, Silvia Reboredo, Asier Gómez-San Juan, María Jesús Martín, Andrés Francesch, Simon Munt, Carmen Cuevas   +8 more
doaj   +1 more source

Acyl depsipeptide (ADEP) resistance in Streptomyces

, 2011
ADEP, a molecule of the acyl depsipeptide family, has an antibiotic activity with a unique mode of action. ADEP binding to the ubiquitous protease ClpP alters the structure of the enzyme.
Philippe Mazodier, Myriam Gominet, Nicolas Seghezzi   +2 more
core   +1 more source

The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase

, 2010
Isopenicillin N synthase (IPNS) is a non-heme iron(II) oxidase, which catalyses the biosynthesis of isopenicillin N (IPN) from the tripeptide δ-L-α-aminoadipoyl-L-cysteinyl-D-valine (LLD-ACV) in a remarkable oxidative bicyclisation reaction.
Ge, Wei, Baldwin, JE, Stok, Jeanette E., Adlington, Robert M., Adlington, RM, Adlington, Robert, Ge, W, Clifton, Ian J., Rutledge, PJ, Stok, JE, Rutledge, Peter J., Baldwin, Jack E., Clifton, IJ   +12 more
core   +1 more source

Tryptophan‐Selective Chemical Modification of Peptides by Thioether‐Mediated Sulfenylation

ChemistryEurope
Chemical modification of biomolecules such as peptides and proteins is an important technology for the development of new functional molecules. Herein, a thioether‐mediated sulfenylation for tryptophan (Trp)‐selective chemical modification under mild ...
Hayate Shida, Akihiro Taguchi, Yuma Tokita, Yan Cui, Momoka Sakamaki, Sho Konno, Atsuhiko Taniguchi, Young Sook Yun, Yuuta Fujikawa, Hiroshi Kaneko, Hidemasa Nakaminami, Yoshio Hayashi   +11 more
doaj   +1 more source

Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor

, 2011
Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same ...
Packham, Graham, Benelkebir, Hanae, Donlevy, Alison M., Ganesan, A., Graham Packham, A. Ganesan, Hanae Benelkebir, Alison M. Donlevy   +7 more
core   +1 more source

Understanding the Role of Macrocycle Size and Amide Linkage in Teixobactin Analogues. [PDF]

Biomolecules
Malkawi R, Weldon-Bee J, Kiptoo E, Das S, Chen Y, Iyer A, Lakshminarayanan R, Zhang Q, Parmar A, Singh I.   +9 more
europepmc   +1 more source

Depsipeptide Analogues of Gly-Ala-Gly: Proton Localization and Effects on Collision-Induced Dissociation. [PDF]

J Am Soc Mass Spectrom
Shira BA, Herndon EC, DeMauro JE, Giuliano MW, Forsythe JG.   +4 more
europepmc   +1 more source

Characterization of Dapalides D and E and Genomic Comparison of the Two Co-Occurring Dapalide-Producing Dapis spp. [PDF]

J Nat Prod
Ellis EK, Ióca LP, Liu J, Chen M, Bruner SD, Ding Y, Paul VJ, Donia MS, Luesch H.   +8 more
europepmc   +1 more source