Results 121 to 130 of about 9,955 (253)

Clovibactin and Staphylococcus aureus: a new weapon against resistant strains

GMS Hygiene and Infection Control
Clovibactin is a new depsipeptide and highly efficacious against () , including methicillin-resistant and vancomycin-resistant , with no apparent resistance. Clovibactutclasses current antibiotics such as vancomycin.
Adeiza, Shuaibu Suleiman
doaj   +1 more source

Konformationsanalyse und Kinetik der Konformationsänderungen von membranaktiven Antibiotika

CHIMIA, 1972
Molecular properties of the membrane active antibiotics enniatin B, valinomycin and gramicidin A were investigated in various solvents. The conformational rearrangements of these antibiotics have been studied as a function of solvent polarity by ...
E. Grell, F. Eggers, Th. Funck
doaj   +1 more source

Total Synthesis of Cyclodepsipeptide Xylaroamide A

Chemistry
Cyclodepsipeptides constitute a structurally diverse class of natural products composed of amino acid and hydroxy acid residues interconnected through both amide and ester bonds.
Rongping Wu, Dongping Qiu, Yogini S. Jaiswal, Xinrong Xie, Leonard L. Williams, Yu Fan, Hedong Bian, Yifu Guan, Shaoyang Su   +8 more
doaj   +1 more source

Kulokekahilide-2, a Cytotoxic Depsipeptide from a Cephalaspidean Mollusk Philinopsis speciosa^†

, 2016
A cytotoxic depsipeptide, kulokekahilide-2 (1), was isolated from a cephalaspidean mollusk, Philinopsis speciosa. The structure elucidation of kulokekahilide-2 was carried out by spectroscopic analysis and chemical degradation.
Wesley Y. Yoshida (1265682), Liu Yang (23752), Yoichi Nakao (1605271), Yuuki Takada (2709382), Junji Kimura (2709379), Paul J. Scheuer (2709376), Susan L. Mooberry (665537)   +6 more
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Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA)

Pharmaceutics, 2018
Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance.
Ruba Malkawi, Abhishek Iyer, Anish Parmar, Daniel G. Lloyd, Eunice Tze Leng Goh, Edward J. Taylor, Sarir Sarmad, Annemieke Madder, Rajamani Lakshminarayanan, Ishwar Singh   +9 more
doaj   +1 more source

Depsipeptide Methodology for Solid-Phase Peptide Synthesis:  Circumventing Side Reactions and Development of an Automated Technique via Depsidipeptide Units^†,‡

, 2016
The depsipeptide technique is a recently developed method for peptide synthesis which is applicable to difficult sequences when the synthetic difficulty arises because of aggregation phenomena.
Michael Bienert (2355265), Eberhard Krause (245266), Calin Dan Sferdean (2532814), Rudolf Dölling (2532817), Louis A. Carpino (2355259), Irene Coin (2062345), Michael Beyermann (711881)   +6 more
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Georgamide, a New Cyclic Depsipeptide with an Alkynoic Acid Residue from an Australian Cyanobacterium

, 2016
A cyclic depsipeptide, georgamide (1), was isolated from an Australian cyanobacterium and characterized by spectroscopic means. The constituent units were five amino acid residues, one each of l-Thr, l-Pro, l-Val, N-Me-l-Val, and N-Me-l-Phe, and two ...
Karen L. Erickson (2254336), Feng Wan (565437)   +1 more
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Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

Biologics: Targets & Therapy, 2013
Katherine Ververis,1 Alison Hiong,1 Tom C Karagiannis,1,* Paul V Licciardi2,*1Epigenomic Medicine, Alfred Medical Research and Education Precinct, 2Allergy and Immune Disorders, Murdoch Childrens Research Institute, Melbourne, VIC, Australia*These ...
Ververis K, Hiong A, Karagiannis TC, Licciardi PV   +3 more
doaj  

Total Synthesis and Stereochemical Assignment of Burkholdac B, a Depsipeptide HDAC Inhibitor

, 2016
Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same ...
Graham Packham (1277634), Alison M. Donlevy (2136052), A. Ganesan (434850), Hanae Benelkebir (2136049)   +3 more
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Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor

, 2011
Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full stereochemical assignment of the natural product. It is proposed that burkholdac B is identical to thailandepsin A independently isolated by Cheng from the same ...
Packham, Graham, Benelkebir, Hanae, Donlevy, Alison M., Ganesan, A., Graham Packham, A. Ganesan, Hanae Benelkebir, Alison M. Donlevy   +7 more
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