Results 91 to 100 of about 7,439 (222)

A Convergent Synthesis of the Proposed Structure of Antitumor Depsipeptide Stereocalpin A

, 2016
The total synthesis of the proposed structure of anticancer agent stereocalpin A is described. The synthesis features a diastereoselective synthesis of a 5-hydroxy-2,4-dimethyl-3-oxooctanoic acid unit with asymmetric anti- and syn-aldol reactions as the ...
Chun-Xiao Xu (1955455), Arun K. Ghosh (468637)   +1 more
core   +3 more sources

The First Biologically Active Synthetic Analogues of FK228, the Depsipeptide Histone Deacetylase Inhibitor

, 2016
The FK228 and spiruchostatin bicyclic depsipeptide natural products are among the most potent histone deacetylase (HDAC) inhibitors known. Although FK228 is in advanced clinical trials, the complexity of the natural products has precluded mechanistic ...
Alexander Yurek-George (1748584), Shijun Wen (1670017), Helen Rogers (415534), Fay Habens (518679), Satoko Maeda (2467747), Minoru Yoshida (151970), Graham Packham (1277634), A. Ganesan (434850), Alex Hon Kit Mo (2467750), Alexander Richard Liam Cecil (2467753)   +9 more
core   +1 more source

Thailandepsin A

Acta Crystallographica Section E, 2011
Thailandepsin A [systematic name: (E)-(1S,5S,6R,9S,20R)-6-[(2S)-butan-2-yl]-5-hydroxy-20-[2-(methylsulfanyl)ethyl]-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docosa-15-ene-3,8,18,21-tetraone], C23H37N3O6S3, is a newly reported [Wang et al. (2011). J.
Cheng Wang, Yi-Qiang Cheng
doaj   +1 more source

Szentiamide, an -formylated Cyclic Depsipeptide from DSM 16338

Natural Product Communications, 2011
Szentiamide ( 1 ) a new cyclic hexadepsipeptide was isolated from the culture broth of the entomopathogenic bacterium Xenorhabdus szentirmaii DSM 16338 T .
Birgit Ohlendorf, Sven Simon, Jutta Wiese, Johannes F. Imhoff   +3 more
doaj   +1 more source

First total synthesis of hormaomycin, a naturally occurring depsipeptide with interesting biological activities

, 2004
Some unique features were disclosed during the structure elucidation of the cyclic depsipeptide hormaomycin (1), first isolated in 1989 from a Streptomyces griseoflavus strain and found to have quite an interesting spectrum of biological activities ...
de Meijere, Armin, Zlatopolskiy, Boris D.   +1 more
core   +1 more source

FK228 from Burkholderia thailandensis MSMB43

Acta Crystallographica Section E, 2012
FK228 [systematic name: (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone], C24H36N4O6S2, also known as FR901228, depsipeptide, NSC 630176, romidepsin, and ...
Xiang-Yang Liu, Cheng Wang, Yi-Qiang Cheng   +2 more
doaj   +1 more source

Multicomponent Synthesis of Cyclic Depsipeptide Mimics by Ugi Reaction Including Cyclic Hemiacetals Derived from Asymmetric Organocatalysis

, 2016
The synthesis of novel cyclic depsipeptide mimics by means of an organocatalytic conjugate addition, leading to chiral cyclic hemiacetals, followed by a multicomponent reaction with α-amino acids and isocyanides, is described. The initial organocatalytic
Odette Concepción (1392715), Márcio W. Paixão (1392730), Alexander F. de la Torre (1392727), Daniel G. Rivera (1392718), Arlene G. Correa (1392724), Radell Echemendia (1392721)   +5 more
core   +1 more source

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.

PLoS Pathogens, 2015
UnlabelledPharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV-1 infection.
Ole S Søgaard, Mette E Graversen, Steffen Leth, Rikke Olesen, Christel R Brinkmann, Sara K Nissen, Anne Sofie Kjaer, Mariane H Schleimann, Paul W Denton, William J Hey-Cunningham, Kersten K Koelsch, Giuseppe Pantaleo, Kim Krogsgaard, Maja Sommerfelt, Remi Fromentin, Nicolas Chomont, Thomas A Rasmussen, Lars Østergaard, Martin Tolstrup   +18 more
doaj   +1 more source

Total synthesis of the antifungal depsipeptide petriellin A

, 2011
Publication Date (Web): July 8, 2011We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase
Sleebs, MM, Karas, J, Maharani, R, Sleebs, M., John Karas, Scanlon, D, Hughes, AB, Marianne M. Sleebs, Scanlon, D., Maharani, R., Denis Scanlon, Hughes, A., Karas, J., Rani Maharani, Andrew B. Hughes   +14 more
core   +1 more source

Preclinical Assessment of a 68Ga-DOTA-Functionalized Depsipeptide as a Radiodiagnostic Infection Imaging Agent

Molecules, 2017
The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed in (NZR1) healthy rabbits; (NZR2)
Thomas Ebenhan, Botshelo Brenda Mokaleng, Jacobus Daniel Venter, Hendrik Gert Kruger, Jan Rijn Zeevaart, Mike Sathekge   +5 more
doaj   +1 more source