Results 81 to 90 of about 7,439 (222)
Elucidation of novel turnagainolides and their biosynthetic gene cluster in Bacillus subtilis
Applied and Environmental MicrobiologyTurnagainolides represent a unique class of cyclic depsipeptides characterized by the presence of a rare (E)-3-hydroxy-5-phenylpent-4-enoic acid (Hppa) residue, exhibiting diverse bioactivities.
Peng Li +8 more
doaj +1 more source
The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
A Concise Route to the Proposed Structure of Lydiamycin B, an Antimycobacterial Depsipeptide
, 2016 The total synthesis of four possible isomers with the proposed structure of antimycobacterial depsipeptide lydiamycin B is achieved. None of them shows identical NMR data with those reported for natural lydiamycin B, indicating that further structural ...
Dawei Ma (275249) +2 more
core +1 more source
Transcription inhibition by the depsipeptide antibiotic salinamide A
eLife, 2014 We report that bacterial RNA polymerase (RNAP) is the functional cellular target of the depsipeptide antibiotic salinamide A (Sal), and we report that Sal inhibits RNAP through a novel binding site and mechanism.
David Degen +12 more
doaj +1 more source
Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham +11 more
wiley +1 more source
, 2016 Total Syntheses of Depsipeptide Elastase Inhibitors YM-47141 and YM-47142 with use of Ylide Protection and Coupling ...
Jyun-Hung Chen (2994912) +2 more
core +1 more source
, 2021 The mechanism by which informational polymers first formed on the early earth is currently unknown. The RNA world hypothesis implies that RNA oligomers were produced prebiotically, before the emergence of enzymes, but the demonstration of such a process ...
Ramanarayanan Krishnamurthy +13 more
core +1 more source
Advanced Methods for Detection of Bacillus cereus and Its Pathogenic Factors
Sensors, 2020 Bacillus cereus is an opportunistic foodborne pathogen causing food intoxication and infectious diseases. Different toxins and pathogenic factors are responsible for diarrheal syndrome, like nonhemolytic enterotoxin Nhe, hemolytic enterotoxin Hbl ...
Nalini Ramarao +3 more
doaj +1 more source
, 2007 The FK228 and spiruchostatin bicyclic depsipeptide natural products are among the most potent histone deacetylase (HDAC) inhibitors known. Although FK228 is in advanced clinical trials, the complexity of the natural products has precluded mechanistic ...
Packham, Graham +9 more
core +1 more source
Combined Application of Orthogonal Sortases and Depsipeptide Substrates for Dual Protein Labeling
, 2022 Staphylococcus aureus sortase A is a transpeptidase that has been extensively exploited for site-specific modification of proteins and was originally used to attach a labeling reagent containing an LPXTG recognition sequence to a protein or peptide with ...
Michael E. Webb (4419319) +4 more
core +1 more source