Results 11 to 20 of about 10,903 (206)

A new depsipeptide antibiotic, citropeptin. [PDF]

Agricultural and Biological Chemistry, 1990
An actinomycete identified as Streptomyces flavidovirens was found to produce a new cyclic hexadepsipeptide antibiotic, designated citropeptin. Citropeptin showed antitumor activity against P388 murine leukemia.
Y, Hayakawa, M, Nakagawa, Y, Toda, H, Seto   +3 more
openaire   +3 more sources

Synthesis of Depsipeptides via Isocyanide-Based Consecutive Bargellini–Passerini Multicomponent Reactions

SynOpen, 2021
An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid, Mohammad Mahdi Rostami, Ahmad Shaabani, Behrouz Notash   +3 more
doaj   +1 more source

Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment

Neoplasia: An International Journal for Oncology Research, 2009
Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. However, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor,
Yang Yang, Ying Zhao, Wenjuan Liao, Jing Yang, Lipeng Wu, Zhixing Zheng, Yu Yu, Wen Zhou, Lian Li, Jingnan Feng, Haiying Wang, Wei-Guo Zhu   +11 more
doaj   +1 more source

Copolymerization of ε-caprolactone and morpholine-2,5-dione derivatives [PDF]

, 1992
Novel biodegradable poly(ester-amide)s were prepared by ring-opening copolymerization of -caprolactone and 3- and/or 6-alkyl-substituted morpholine-2,5-dione derivatives.
Dijkstra, Pieter J., Feijen, Jan, Klap, Richard, Veld, Peter J.A. in 't, Wei-Ping, Ye   +4 more
core   +4 more sources

Synthesis of biodegradable polyesteramides with pendant functional groups [PDF]

, 1992
Morpholine-2,5-dione derivatives having substituents with benzyl-protected carboxylic acid, benzyloxycarbonyl-protected amine and p-methoxy-protected thiol groups, respectively, were prepared in 29-58% yield by cyclization of the corresponding N-[(2RS ...
Dijkstra, Pieter J., Feijen, Jan, Veld, Peter J.A. in 't   +2 more
core   +3 more sources

Total Synthesis of Pagoamide A

Molecules, 2021
The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous ...
Fusong Wu, Jie Yu, Jiawei Meng, Yian Guo, Tao Ye   +4 more
doaj   +1 more source

A New Depsipeptide Antibiotic, Variapeptin [PDF]

Agricultural and Biological Chemistry, 1990
A culture similar to Streptomyces variabilis was found to produce a novel cyclic hexadepsipeptide antibiotic named variapeptin. Variapeptin is structurally related to azinothricin, A83586C, and citropeptin. The antibiotic was active against Gram-positive bacteria and showed cytotoxic activity against mammalian cells.
M, Nakagawa, Y, Hayakawa, K, Adachi, H, Seto   +3 more
openaire   +3 more sources

Depsipeptide substrates for sortase-mediated N-terminal protein ligation [PDF]

, 2014
Technologies that allow the efficient chemical modification of proteins under mild conditions are widely sought after. Sortase-mediated peptide ligation provides a strategy for modifying the N or C terminus of proteins. This protocol describes the use of
AJ Link, BL Nilsson, CP Guimaraes, CS Theile, Daniel J Williamson, DJ Suich, DJ Williamson, DP Baker, E Saxon, H Ton-That, H Ton-That, HY Mao, JM Antos, JM Antos, MG Jobling, Michael E Webb, MW Popp, MW-L Popp, NJ Agard, R Parthasarathy, S Samantaray, S Tsukiji, SK Mazmanian, SK Mazmanian, T Yamamoto, VV Rostovtsev, W Bruce Turnbull, X Guo   +27 more
core   +1 more source

Characterization of cereulide synthetase, a toxin-producing macromolecular machine.

PLoS ONE, 2015
Cereulide synthetase is a two-protein nonribosomal peptide synthetase system that produces a potent emetic toxin in virulent strains of Bacillus cereus.
Diego A Alonzo, Nathan A Magarvey, T Martin Schmeing   +2 more
doaj   +1 more source

A cyclic carbo-isosteric penta-depsipeptide: cyclo(Phe1–d-Ala2–Gly3–Phe4–APO5)

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, cyclo(Phe1–d-Ala2–Gly3–Phe4–APO5), C26H32N4O5, is the minor diastereoisomer of a cyclic penta-peptidomimetic analogue containing a novel 2-aminopropyl lactone (APO) motif, which displays the same number of atoms as the native amino ...
Stéphanie M. Guéret, Trixie Wagner
doaj   +1 more source