Results 21 to 30 of about 10,903 (206)

Stereocalpin B, a New Cyclic Depsipeptide from the Antarctic Lichen Ramalina terebrata

Metabolites, 2022
Stereocalpin B, a new cyclic depsipeptide (1), and a new dibenzofuran derivative (3), were isolated from the Antarctic lichen, Ramalina terebrata (Ramalinaceae), along with a known cyclic depsipeptide (2).
Seulah Lee, Se Yun Jeong, Dieu Linh Nguyen, Jae Eun So, Ki Hyun Kim, Ji Hee Kim, Se Jong Han, Sung-Suk Suh, Jun Hyuck Lee, Ui Joung Youn   +9 more
doaj   +1 more source

Chemical Classification of Cyclic Depsipeptides

Current Protein & Peptide Science, 2017
Cyclic depsipeptides (CDPs) are a family of cyclic peptide-related compounds, of which the ring is mainly composed of amino- and hydroxy acid residues joined by amide and ester bonds (at least one), leading to a wide diversity of fascinating chemical structures. They differ in both their ring structure and their side chains, especially by the nature of
Taevernier, Lien, Wynendaele, Evelien, Gevaert, Bert, De Spiegeleer, Bart   +3 more
openaire   +3 more sources

Hijacking the Electron Train: Menaquinone-Binding Antimicrobial Peptides. [PDF]

Chembiochem
Menaquinone is an emerging target for antimicrobial peptides. Could it be the new Achilles’ Heel of bacteria? The rise of antibiotic resistance threatens to undermine modern medicine, making the development of new antibiotics and novel targets an urgent priority.
Matheson EJ, Cochrane SA.
europepmc   +2 more sources

Sortase-mediated labelling of lipid nanodiscs for cellular tracing [PDF]

, 2016
Lipid nanodiscs have broad applications in membrane protein assays, biotechnology and materials science. Chemical modification of the nanodiscs to expand their functional attributes is generally desirable for all of these uses.
A. Ivona Petrache, Almer, Bayburt, Bayburt, Beales, Bricarello, Carney, Chen, Daniel J. Williamson, Darren C. Machin, Denisov, Denisov, Frank, Geerts, Kim, Knowles, Luthi, Marty, McMahon, Michael E. Webb, Morrison, Nath, Nelson, Ng, Paul A. Beales, Postis, Redmond, Ritchie, Williamson, Williamson, Zheng   +30 more
core   +1 more source

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Biosynthetic Modularity Rules in the Bisintercalator Family of Antitumor Compounds

Marine Drugs, 2014
Diverse actinomycetes produce a family of structurally and biosynthetically related non-ribosomal peptide compounds which belong to the chromodepsipeptide family. These compounds act as bisintercalators into the DNA helix.
Javier Fernández, Laura Marín, Raquel Álvarez-Alonso, Saúl Redondo, Juan Carvajal, Germán Villamizar, Claudio J. Villar, Felipe Lombó   +7 more
doaj   +1 more source

Evidence for Naturally Produced Beauvericins Containing N-Methyl-Tyrosine in Hypocreales Fungi

Toxins, 2019
Beauvericin is a depsipeptide mycotoxin. The production of several beauvericin analogues has previously been shown among various genera among Hypocreales fungi.
Monika Urbaniak, Łukasz Stępień, Silvio Uhlig   +2 more
doaj   +1 more source

Romidepsin induces caspase-dependent cell death in human neuroblastoma cells [PDF]

, 2017
Neuroblastoma is the most common extracranial pediatric solid tumor, arising from the embryonic sympathoadrenal lineage of the neural crest, and is responsible for 15% of childhood cancer deaths.
Hegarty, Shane V., O'Keeffe, Gerard W., O'Leary, Eimear, Solger, Franziska, Sullivan, Aideen M., Togher, Katie L.   +5 more
core   +1 more source

Total synthesis and biological evaluation of fluorinated cryptophycins

Beilstein Journal of Organic Chemistry, 2012
Cryptophycins are cytotoxic natural products that exhibit considerable activities even against multi-drug-resistant tumor cell lines. As fluorinated pharmaceuticals have become more and more important during the past decades, fluorine-functionalized ...
Christine Weiß, Tobias Bogner, Benedikt Sammet, Norbert Sewald   +3 more
doaj   +1 more source

Chromatin remodeling agents for cancer therapy [PDF]

, 2008
Alterations in chromatin structure profoundly influence gene expression during normal cellular homeostasis and malignant transformation. Methylation of cytosines within CpG islands located in promoter and proximal coding regions facilitates recruitment ...
Cinti, Caterina, Estenoz, Mariela, Giordano, Roberto, La Sala, Dario, Magnano, Anna   +4 more
core   +1 more source