Research and Application of Chondroitin Sulfate/Dermatan Sulfate-Degrading Enzymes [PDF]
Frontiers in Cell and Developmental Biology, 2020 Chondroitin sulfate (CS) and dermatan sulfate (DS) are widely distributed on the cell surface and in the extracellular matrix in the form of proteoglycan, where they participate in various biological processes.
Wenshuang Wang +3 more
doaj +6 more sources
Sequencing the Dermatan Sulfate Chain of Decorin [PDF]
Journal of the American Chemical Society, 2017 Glycomics represents one of the last frontiers and most challenging in omic analysis. Glycosylation occurs in the endoplasmic reticulum and the Golgi organelle and its control is neither well-understood nor predictable based on proteomic or genomic analysis.
Kyohei Higashi +2 more
exaly +6 more sources
Delineation of musculocontractural Ehlers–Danlos Syndrome caused by dermatan sulfate epimerase deficiency [PDF]
Molecular Genetics & Genomic Medicine, 2020 Background Musculocontractural Ehlers–Danlos Syndrome (mcEDS) is a rare connective tissue disorder caused by biallelic loss‐of‐function variants in CHST14 (mcEDS‐CHST14) or DSE (mcEDS‐DSE), both of which result in defective dermatan sulfate biosynthesis.
Charlotte K. Lautrup +12 more
doaj +3 more sources
A Fluorescent Probe for Glycosaminoglycans Applied to the Detection of Dermatan Sulfate by a Mix-and-Read Assay [PDF]
Molecules, 2017 Glycosaminoglycans are complex biomolecules of great biological and medical importance. The quantification of glycosaminoglycans, in particular in complex matrices, is challenging due to their inherent structural heterogeneity.
Melissa Rappold +2 more
doaj +3 more sources
Chondroitin / dermatan sulfate modification enzymes in zebrafish development. [PDF]
PLoS ONE, 2015 Chondroitin/dermatan sulfate (CS/DS) proteoglycans consist of unbranched sulfated polysaccharide chains of repeating GalNAc-GlcA/IdoA disaccharide units, attached to serine residues on specific proteins.
Judith Habicher +6 more
doaj +3 more sources
Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders [PDF]
Pharmaceuticals, 2017 The indispensable roles of dermatan sulfate-proteoglycans (DS-PGs) have been demonstrated in various biological events including construction of the extracellular matrix and cell signaling through interactions with collagen and transforming growth factor-
Shuji Mizumoto +3 more
doaj +3 more sources
The Specific Role of Dermatan Sulfate as an Instructive Glycosaminoglycan in Tissue Development. [PDF]
Int J Mol Sci, 2022 The crucial roles of dermatan sulfate (DS) have been demonstrated in tissue development of the cutis, blood vessels, and bone through construction of the extracellular matrix and cell signaling.
Mizumoto S, Yamada S.
europepmc +2 more sources
Data on cloning, expression and biochemical characteristics of a chondroitin sulfate/dermatan sulfate 4-O-endosulfatase [PDF]
Data in Brief, 2023 The data shown in this article are related to the published paper entitled “A novel 4-O-endosulfatase with high potential for the structure-function studies of chondroitin sulfate/dermatan sulfate” in Carbohydrate Polymers.
Lin Wei +9 more
doaj +2 more sources
An Overview of in vivo Functions of Chondroitin Sulfate and Dermatan Sulfate Revealed by Their Deficient Mice. [PDF]
Front Cell Dev Biol, 2021 Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently attached to specific core proteins to form proteoglycans in their biosynthetic pathways.
Mizumoto S, Yamada S.
europepmc +2 more sources
Chondroitin Sulfate/Dermatan Sulfate-Protein Interactions and Their Biological Functions in Human Diseases: Implications and Analytical Tools. [PDF]
Front Cell Dev Biol, 2021 Chondroitin sulfate (CS) and dermatan sulfate (DS) are linear anionic polysaccharides that are widely present on the cell surface and in the cell matrix and connective tissue.
Zhang B, Chi L.
europepmc +2 more sources