Results 171 to 180 of about 232,697 (206)

Dermatan sulfate and chondroitin 6-sulfate conformations

Biochemical and Biophysical Research Communications, 1973
Abstract X-ray diffraction patterns show that dermatan sulfate in oriented, crystalline films occurs as two or three or eight-fold helices. The two-fold helix has a greater axial rise per disaccharide residue [ h = 9.6 A ] than the corresponding chondroitin 6-sulfate helix [ h = 9.3 A ] .
S, Arnott, J M, Guss, D W, Hukins, M B, Matthews   +3 more
openaire   +2 more sources

Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate

FEBS Journal, 2013
The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the polysaccharides, as it generates a more flexible chain with increased binding potentials.
Renata Gustafsson, Emil Tykesson, Edgar M Pera   +2 more
exaly   +2 more sources

Synthesis of disaccharide fragments of dermatan sulfate

Carbohydrate Research, 1989
Condensation of crystalline methyl 2-azido-4,6-O-benzylidene-2-deoxy-beta-D-galactopyranoside with methyl (2,3,4-tri-O-acetyl-alpha-L-idopyranosyl bromide)uronate in dichloromethane, in the presence of silver triflate and molecular sieve, provided 54% of methyl 2-azido-4,6-O-benzylidene-2-deoxy-3-O-(methyl 2,3,4-tri-O-acetyl-alpha-L-idopyranosyluronate)
MARRA, Alberto, XIA D, PETITOU M, SINAY P.   +3 more
openaire   +3 more sources

Immunology of Chondroitin/Dermatan Sulfate

1995
Variable substitutions and locations of the sulfate esters along the backbone of chondroitin/dermatan sulfate chains, combined with their carbohydrate structures, present topographies to immune systems which can be recognized as antigenic. This has led to the development of a number of monoclonal antibodies which recognize distinct epitopes in the ...
V C, Hascall, R J, Midura, J M, Sorrell, A H, Plaas   +3 more
openaire   +2 more sources

Dermatan sulfates of normal and scarred fascia

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2001
We evaluated the composition of dermatan sulfates (DS) derived from 23 samples of normal and 23 samples of scarred fascia lata. We analyzed the molecular weight of intact DS chains and the length of chain regions comprising: (1) clusters of L-iduronate-containing disaccharides ("iduronic sections"); (2) clusters of D-glucuronate-containing ...
E M, Kozma, K, Olczyk, A, Głowacki
openaire   +2 more sources

Pharmacological profile of a native dermatan sulfate

Thrombosis Research, 1992
We performed different "in vivo" investigations to study the pharmacological properties of a native DS: anti-thrombosis by the stasis model, bleeding potential by tail transection bleeding time and template bleeding time, and profibrinolysis by a growing thrombus model and by an established thrombus model.
F M, Santoro, R, Alvarez, F, Fussi
openaire   +2 more sources

Solvolytic depolymerization of chondroitin and dermatan sulfates

Carbohydrate Research, 2009
It is essential to establish a library of glycosaminoglycan oligosaccharides from the chondroitin and dermatan sulfates to investigate their biological functions and structure-activity relationships (SARs). There are several approaches to obtain oligosaccharides using chemical and enzymatic degradation procedures; however, purification of each ...
Toshihiko, Toida, Kenji, Sato, Noriko, Sakamoto, Shinobu, Sakai, Saori, Hosoyama, Robert J, Linhardt   +5 more
openaire   +2 more sources

Dermatan sulfate and heparan sulfate as a biomarker for mucopolysaccharidosis I

Journal of Inherited Metabolic Disease, 2010
AbstractMucopolysaccharidosis I (MPS I) is an autosomal recessive disorder caused by deficiency of α‐L‐iduronidase leading to accumulation of its catabolic substrates, dermatan sulfate (DS) and heparan sulfate (HS), in lysosomes. This results in progressive multiorgan dysfunction and death in early childhood.
Shunji, Tomatsu, Adriana M, Montaño, Toshihiro, Oguma, Vu Chi, Dung, Hirotaka, Oikawa, Talita Giacomet, de Carvalho, María L, Gutiérrez, Seiji, Yamaguchi, Yasuyuki, Suzuki, Masaru, Fukushi, Nobuo, Sakura, Luis, Barrera, Kazuhiro, Kida, Mitsuru, Kubota, Tadao, Orii   +14 more
openaire   +2 more sources

Recent Advances in the Structural Biology of Chondroitin Sulfate and Dermatan Sulfate

Current Opinion in Structural Biology, 2003
Recent glycobiology studies have suggested fundamental biological functions for chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as glycosaminoglycan sidechains of proteoglycans in the extracellular matrix and at cell surfaces.
Hiroshi Kitagawa, Kazuyuki Sugahara, Tadahisa Mikami   +2 more
exaly   +3 more sources

Advances in the Analysis of Chondroitin/Dermatan Sulfate

2006
Publisher Summary Chondroitin/dermatan sulfate (CS/DS) is a glycosaminoglycan (GAG) found in extracellular matrix (ECM) and cell surface and participates in various ECM and cell–ECM interactions. It is made from the alternate addition of glucuronic acid (GlcA) and N‐acetylgalactosamine (GalNAc).
M, Stylianou, I-E, Triantaphyllidou, D H, Vynios   +2 more
openaire   +2 more sources