Results 171 to 180 of about 18,322 (221)
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Biosynthesis of Chondroitin/Dermatan Sulfate
IUBMB Life, 2002AbstractChondroitin sulfate and dermatan sulfate are synthesized as galactosaminoglycan polymers containing N ‐acetylgalactosmine alternating with glucuronic acid. The sugar residues are sulfated to varying degrees and positions depending upon the tissue sources and varying conditions of formation.
Jeremiah E, Silbert, Geetha, Sugumaran
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Dermatan sulfate as a potential therapeutic agent
General Pharmacology: The Vascular System, 19951. Dermatan sulfate is a linear, sulfated polysaccharide and is a glycosaminoglycan component of several important proteoglycans. This minireview discusses the biosynthesis, structure and biological function of dermatan sulfate proteoglycans. 2.
R J, Linhardt, R E, Hileman
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Enzymatic Reconstruction of Dermatan Sulfate
Biochemical and Biophysical Research Communications, 2000We investigated the enzymatic reconstruction of dermatan sulfate (DS) using the transglycosylation reaction of testicular hyaluronidase. First, in order to insert the IdoA-GalNAc disaccharide unit into chondroitin sulfate chains consisting of GlcA-GalNAc disaccharide units, desulfated DS as a donor and pyridylaminated (PA) chondroitin 6-sulfate (Ch6S ...
K, Takagaki +4 more
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Dermatan sulfate and chondroitin 6-sulfate conformations
Biochemical and Biophysical Research Communications, 1973Abstract X-ray diffraction patterns show that dermatan sulfate in oriented, crystalline films occurs as two or three or eight-fold helices. The two-fold helix has a greater axial rise per disaccharide residue [ h = 9.6 A ] than the corresponding chondroitin 6-sulfate helix [ h = 9.3 A ] .
S, Arnott +3 more
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Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate
Current Drug Discovery Technologies, 2008Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections. Major GAGs include heparin (Hep)/heparan sulfate, and chondroitin sulfate (CS)/dermatan sulfate (DS).
Shuhei, Yamada, Kazuyuki, Sugahara
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Immunology of Chondroitin/Dermatan Sulfate
1995Variable substitutions and locations of the sulfate esters along the backbone of chondroitin/dermatan sulfate chains, combined with their carbohydrate structures, present topographies to immune systems which can be recognized as antigenic. This has led to the development of a number of monoclonal antibodies which recognize distinct epitopes in the ...
V C, Hascall +3 more
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Synthesis of disaccharide fragments of dermatan sulfate
Carbohydrate Research, 1989Condensation of crystalline methyl 2-azido-4,6-O-benzylidene-2-deoxy-beta-D-galactopyranoside with methyl (2,3,4-tri-O-acetyl-alpha-L-idopyranosyl bromide)uronate in dichloromethane, in the presence of silver triflate and molecular sieve, provided 54% of methyl 2-azido-4,6-O-benzylidene-2-deoxy-3-O-(methyl 2,3,4-tri-O-acetyl-alpha-L-idopyranosyluronate)
MARRA, Alberto +3 more
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The anticoagulant effect of heparan sulfate and dermatan sulfate
Thrombosis Research, 1976Abstract The potency of the various glycosaminoglycans (GAGs) as anticoagulants in the activated partial thromboplastin time (APTT) test system has been investigated. Heparin, heparan sulfate (HS) and dermatan sulfate (DS) exhibit anticoagulant effect.
A N, Teien, U, Abildgaard, M, Höök
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Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria
Glycoconjugate Journal, 2016Sulfatases that specifically catalyze the hydrolysis of the sulfate groups on chondroitin sulfate (CS)/dermatan sulfate (DS) poly- and oligosaccharides belong to the formylglycine-dependent family of sulfatases and have been widely found in various mammalian and bacterial organisms.
Shumin, Wang +2 more
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Plasmatic dermatan sulfate and chondroitin sulfate determination in mucopolysaccharidoses
Journal of Pharmaceutical and Biomedical Analysis, 2013The evaluation of plasmatic galactosaminoglycans, dermatan sulfate (DS) and chondroitin sulfate (CS) can be helpful in the early identification of MPS patients, also considering that primary storage of one type of GAG can lead to secondary accumulation of other lysosomal substrates.
Nicola, Volpi +8 more
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