Results 181 to 190 of about 11,964 (213)

Pharmacological profile of a native dermatan sulfate

Thrombosis Research, 1992
We performed different "in vivo" investigations to study the pharmacological properties of a native DS: anti-thrombosis by the stasis model, bleeding potential by tail transection bleeding time and template bleeding time, and profibrinolysis by a growing thrombus model and by an established thrombus model.
F M, Santoro, R, Alvarez, F, Fussi
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Solvolytic depolymerization of chondroitin and dermatan sulfates

Carbohydrate Research, 2009
It is essential to establish a library of glycosaminoglycan oligosaccharides from the chondroitin and dermatan sulfates to investigate their biological functions and structure-activity relationships (SARs). There are several approaches to obtain oligosaccharides using chemical and enzymatic degradation procedures; however, purification of each ...
Toshihiko, Toida, Kenji, Sato, Noriko, Sakamoto, Shinobu, Sakai, Saori, Hosoyama, Robert J, Linhardt   +5 more
openaire   +2 more sources

Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate

Current Opinion in Structural Biology, 2003
Recent glycobiology studies have suggested fundamental biological functions for chondroitin, chondroitin sulfate and dermatan sulfate, which are widely distributed as glycosaminoglycan sidechains of proteoglycans in the extracellular matrix and at cell surfaces.
Kazuyuki Sugahara, Tadahisa Mikami, Toru Uyama   +2 more
exaly   +3 more sources

Dermatan sulfate and heparan sulfate as a biomarker for mucopolysaccharidosis I

Journal of Inherited Metabolic Disease, 2010
AbstractMucopolysaccharidosis I (MPS I) is an autosomal recessive disorder caused by deficiency of α‐L‐iduronidase leading to accumulation of its catabolic substrates, dermatan sulfate (DS) and heparan sulfate (HS), in lysosomes. This results in progressive multiorgan dysfunction and death in early childhood.
Shunji, Tomatsu, Adriana M, Montaño, Toshihiro, Oguma, Vu Chi, Dung, Hirotaka, Oikawa, Talita Giacomet, de Carvalho, María L, Gutiérrez, Seiji, Yamaguchi, Yasuyuki, Suzuki, Masaru, Fukushi, Nobuo, Sakura, Luis, Barrera, Kazuhiro, Kida, Mitsuru, Kubota, Tadao, Orii   +14 more
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Plasmatic dermatan sulfate and chondroitin sulfate determination in mucopolysaccharidoses

Journal of Pharmaceutical and Biomedical Analysis, 2013
The evaluation of plasmatic galactosaminoglycans, dermatan sulfate (DS) and chondroitin sulfate (CS) can be helpful in the early identification of MPS patients, also considering that primary storage of one type of GAG can lead to secondary accumulation of other lysosomal substrates.
Nicola, Volpi, Francesca, Maccari, Fabio, Galeotti, Lucia, Zampini, Lucia, Santoro, Lucia, Padella, Tiziana, Galeazzi, Orazio, Gabrielli, Giovanni V, Coppa   +8 more
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Potential Therapeutic Application of Chondroitin Sulfate/Dermatan Sulfate

Current Drug Discovery Technologies, 2008
Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections. Major GAGs include heparin (Hep)/heparan sulfate, and chondroitin sulfate (CS)/dermatan sulfate (DS).
Shuhei, Yamada, Kazuyuki, Sugahara
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Advances in the Analysis of Chondroitin/Dermatan Sulfate

2006
Publisher Summary Chondroitin/dermatan sulfate (CS/DS) is a glycosaminoglycan (GAG) found in extracellular matrix (ECM) and cell surface and participates in various ECM and cell–ECM interactions. It is made from the alternate addition of glucuronic acid (GlcA) and N‐acetylgalactosamine (GalNAc).
M, Stylianou, I-E, Triantaphyllidou, D H, Vynios   +2 more
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Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria

Glycoconjugate Journal, 2016
Sulfatases that specifically catalyze the hydrolysis of the sulfate groups on chondroitin sulfate (CS)/dermatan sulfate (DS) poly- and oligosaccharides belong to the formylglycine-dependent family of sulfatases and have been widely found in various mammalian and bacterial organisms.
Shumin, Wang, Kazuyuki, Sugahara, Fuchuan, Li   +2 more
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Dermatan Sulfate in Pharmaceutical Heparins

Thrombosis and Haemostasis, 1987
A S, Perlin, F, Sauriol, B, Cooper, J, Folkman   +3 more
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Pharmacologic properties of a low molecular weight dermatan sulfate: comparison with unfractionated dermatan sulfate.

The Journal of laboratory and clinical medicine, 1990
The anticoagulant, pharmacodynamic, and antithrombotic properties of a low molecular weight dermatan sulfate (molecular weight range 1600 to 8000, peak 4000) were compared with those of unfractionated dermatan sulfate (molecular weight range 12,000 to 45,000, peak 25,000).
F, Dol, M, Petitou, J C, Lormeau, J, Choay, C, Caranobe, P, Sie, S, Saivin, G, Houin, B, Boneu   +8 more
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