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Dermatan sulfate: Recent structural and activity data

Carbohydrate Polymers, 2010
Abstract DS is a natural, complex polysaccharide which plays an important role in cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections. Although its clinical use is limited, DS performs interesting biological activities, which should help in the development of DS-based therapeutics, such as drugs for parasitic ...
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Vascular Dermatan Sulfate and Heparin Cofactor II

2010
Heparin cofactor II (HCII) is a plasma protease inhibitor of the serpin family that inactivates thrombin by forming a covalent 1:1 complex. The rate of complex formation increases more than 1000-fold in the presence of dermatan sulfate (DS). Endothelial injury allows circulating HCII to enter the vessel wall, where it binds to DS and presumably becomes
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