Results 91 to 100 of about 80,074 (304)

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Regulation of human Δ-6 desaturase gene transcription: identification of a functional direct repeat-1 element

Journal of Lipid Research, 2003
The rate-limiting step in 20:4(n-6) and 22:6(n-3) synthesis is the desaturation of 18:2(n-6) and 18:3(n-3) by Δ-6 desaturase. In this report, we demonstrate that n-6 and n-3 PUFAs suppressed the hepatic expression of rodent Δ-6 desaturase by inhibiting ...
Chongren Tang, Hyekung P. Cho, Manabu T. Nakamura, Steven D. Clarke   +3 more
doaj   +1 more source

Isolation and characterization of a cDNA encoding a delta8 sphingolipid desaturase from Aquilegia vulgaris

, 2002
We have isolated a cDNA encoding the Delta(8) sphingolipid desaturase from the plant Aquilegia vulgaris L. via a PCR-based strategy using primers designed to target the conserved histidine box regions of microsomal desaturases.
Sayanova, O. V., Michaelson, L. V., Stobart, A. K., Napier, J. A., Longman, A. J.   +4 more
core   +1 more source

Molecular cloning and characterization of a novel microsomal oleate desaturase gene DiFAD2 from Davidia involucrata Baill [PDF]

, 2010
In the conversion of oleic acid to linoleic acid, δ12-fatty acid desaturase (δ12-FAD) is involved. Based on the conserved oligo amino acid residues of the FAD2 genes from other plants, a new full-length cDNA (DiFAD2) encoding a δ12-FAD was cloned from ...
F. Chen, N. Lei, B. Niu, Y. Xu, J. Chen, L. Tang, S. Wang, J. Zhou, S. Peng   +8 more
core   +1 more source

Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat Δ6-desaturase activity

Journal of Lipid Research, 2004
The Δ6-desaturase catalyzes key steps in long-chain polyunsaturated fatty acid biosynthesis. Although the gene coding for this enzyme has been isolated in diverse animal species, the protein structure remains poorly characterized.
Hervé Guillou, Sabine D'Andrea, Vincent Rioux, Romain Barnouin, Stéphanie Dalaine, Frédérique Pedrono, Sophie Jan, Philippe Legrand   +7 more
doaj   +1 more source

Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health

Lipids in Health and Disease, 2020
Background The aim was to investigate if fatty acid profile and estimated desaturase activities; stearoyl CoA-desaturase (SCD), delta-5-desaturase and delta-6-desaturase (D5D; D6D), differ between individuals with metabolically healthy (MH) and unhealthy
Karianne Svendsen, Thomas Olsen, Tove C. Nordstrand Rusvik, Stine M. Ulven, Kirsten B. Holven, Kjetil Retterstøl, Vibeke H. Telle-Hansen   +6 more
doaj   +1 more source

Desaturase Genes And Their Use (Patent CA 2311472 A1)

, 1999
cDNA encoding C. elegans .DELTA.6 desaturase has been cloned and sequenced, and the .DELTA.6 desaturase amino acid sequence has been determined. The C.
Napier, J. A.
core  

Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase

, 2003
The Ranunculaceae are known to accumulate a wide range of unusual fatty acids in their seed lipids, and this variability has been advocated as a taxonomic marker. The Anemone species, Anemone leveillei L. and Anemone rivularis Buch.-Ham., have previously
Pickett, J. A., Sayanova, Olga, Sayanova, O. V., Michaelson, L. V., Michaelson, Louise V., Napier, Johnathan A., Napier, J. A., Whitney, Heather M., Whitney, H. M., Pickett, John A.   +9 more
core   +1 more source

Role of Stearoyl-CoA Desaturase 1 in Cardiovascular Physiology

, 2023
Stearoyl-CoA desaturase is a rate-limiting enzyme in the synthesis of monounsaturated fatty acids. Monounsaturated fatty acids limit the toxicity of exogenous saturated fats. Studies have shown that stearoyl-CoA desaturase 1 is involved in the remodeling
Volodymyr V. Balatskyi, Pawel Dobrzyn
core   +1 more source

Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study

Lipids in Health and Disease, 2017
Background Visceral fat accumulation in overweight status has been resulted in changes of fatty acid profiles. The fatty acids profiles can be altered by fatty acid desaturase; the activity of which is highly associated with obesity and other metabolic ...
Miso Kang, Ayoung Lee, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Dong Yeob Shin, Jong Ho Lee   +6 more
doaj   +1 more source