Results 91 to 100 of about 84,621 (282)

Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study

Lipids in Health and Disease, 2017
Background Visceral fat accumulation in overweight status has been resulted in changes of fatty acid profiles. The fatty acids profiles can be altered by fatty acid desaturase; the activity of which is highly associated with obesity and other metabolic ...
Miso Kang, Ayoung Lee, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Dong Yeob Shin, Jong Ho Lee   +6 more
doaj   +1 more source

An unusual desaturase in Aquilegia vulgaris

Biochemical Society Transactions, 2000
Aquilegia vulgaris seed oil contains high levels of the rare fatty acid columbinic acid (18:3 Δ5,9,12), which is unusual in having the double bond at the Δ5 carbon in the trans configuration. Columbinic acid was found to be a seed-specific fatty acid not only present in the storage oil but also in membrane lipids.
Longman, A. J., Michaelson, L. V., Sayanova, O. V., Napier, J. A., Stobart, A. K.   +4 more
openaire   +2 more sources

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Infection mechanisms of Rhizoctonia cerealis in wheat

iMeta, EarlyView.
We discover that R. cerealis (Rc) is a primary pathogen causing sharp eyespot of wheat after 335 distinct isolates were isolated from 1683 SE‐diseased wheat plants across China over 7 years using a single hyphal tip isolation method. We then generated high‐quality reference genomes via de novo sequencing of five representative Rc isolates and ...
Yan Ren, Ti Liu, Heying Zhao, Qirun Qian, Lufei Cui, Zhipeng Sun, Wenkai Yang, Peng Guo, Sisheng Wang, Lingran Zhang, Congwei Sun, Aolin Jia, Ning Zhang, Feng Chen   +13 more
wiley   +1 more source

A new class of lipid desaturase central to sphingolipid biosynthesis and signalling [PDF]

, 2002
Sphingolipids and their phosphorylated metabolites play crucial roles in intracellular signaling in animals, and evidence is emerging for analogous situations in fungi and plants.
Michaelson, Louise V., Michaelson, L. V., Napier, Johnathan A, Napier, J. A., Dunn, T. M., Dunn, Teresa M   +5 more
core  

Decoding ferroptosis via integrated multi‐omics analyses in rice blast

iMeta, EarlyView.
The rice‐Magnaporthe oryzae pathosystem is presented as a host‐pathogen ferroptosis model. Multi‐omics insights connect ferroptosis to several cellular processes, such as iron homeostasis, reactive oxygen species (ROS)/redox imbalance, and polyunsaturated fatty acid‐containing phospholipid (PUFA‐PL) peroxidation, under multiple regulators in rice and M.
Zhibin Liang, Qing Shen, Nam Khoa Nguyen, Ruhui Long, Yuming Ma, Qiao Liu, Naweed I. Naqvi, Nam‐Soo Jwa, Yi‐Zhen Deng   +8 more
wiley   +1 more source

Functional characterisation of two cytochrome b 5-fusion desaturases from Anemone leveillei : the unexpected identification of a fatty acid delta6-desaturase

, 2003
The Ranunculaceae are known to accumulate a wide range of unusual fatty acids in their seed lipids, and this variability has been advocated as a taxonomic marker. The Anemone species, Anemone leveillei L. and Anemone rivularis Buch.-Ham., have previously
Pickett, J. A., Sayanova, Olga, Sayanova, O. V., Michaelson, L. V., Michaelson, Louise V., Napier, Johnathan A., Napier, J. A., Whitney, Heather M., Whitney, H. M., Pickett, John A.   +9 more
core   +1 more source

Role of Stearoyl-CoA Desaturase 1 in Cardiovascular Physiology

, 2023
Stearoyl-CoA desaturase is a rate-limiting enzyme in the synthesis of monounsaturated fatty acids. Monounsaturated fatty acids limit the toxicity of exogenous saturated fats. Studies have shown that stearoyl-CoA desaturase 1 is involved in the remodeling
Volodymyr V. Balatskyi, Pawel Dobrzyn
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase

, 2006
The rate limiting steps in the conversion of 18-carbon unsaturated fatty acids to 20- and 22-carbon products are catalyzed by two desaturase enzymes (Delta5-desaturase and Delta6-desaturase) found within a lipid desaturase gene cluster.
Dreesen, TD, Tekle, M,, Clarke, SD, Gettys, TW, Adamson, AW, Tang, C, Cho, HP   +6 more
core   +1 more source