Results 121 to 130 of about 84,621 (282)

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Linoleic Acid Enhances Murine Natural Killer Cell Function In Vitro but Compromises Mitochondrial Bioenergetic Function During Retroviral Infection

Immunology, EarlyView.
Natural Killer (NK) cells are potent effectors against virus‐infected and tumour cells. During Friend Virus (FV) infection, fatty acid metabolism supports NK‐cell effector functions. Here, we found that NK cells from FV‐infected mice preferentially take up linoleic acid (LA), which reduced proliferation, mitochondrial function, and increased reactive ...
Vaasudevan Sridhar, Simone Schimmer, Tanja Werner, Rachel Giesen, Mohamed Saad, Constantin P. Krempe, Sven W. Meckelmann, Ulf Dittmer, Elisabeth Littwitz‐Salomon   +8 more
wiley   +1 more source

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

Fatty Acid Profile and Desaturase Activity in Obesity: Roles, Mechanisms, and Clinical Relevance

Metabolites
Background: Obesity is a complex metabolic disease associated with several health complications, including insulin resistance, hypertension, and type 2 diabetes mellitus.
Michalina Banaszak, Ilona Górna, Sławomira Drzymała-Czyż   +2 more
doaj   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Watermelon genotype‐independent transformation via direct organogenesis from the cotyledon base

Journal of Integrative Plant Biology, EarlyView.
Inducing adventitious buds from the base of watermelon cotyledon through direct organogenesis resulted in a watermelon genetic transformation system that overcomes regeneration barriers and genotype limitations.
Jing Zhang, Yu‐Xuan Li, Rui Sun, Ding‐Ding Zuo, Zhong‐Hou Zhu, Xue‐Jie Zhu, Da‐Long Guo   +6 more
wiley   +1 more source

Fine‐tuning fatty acid composition enhances rice resistance to bacterial blight

Journal of Integrative Plant Biology, EarlyView.
Genome editing to insert an inhibitory element into the 5' untranslated region of the stearoyl‐acyl carrier protein desaturase gene OsSSI2 fine‐tuned fatty acid composition, creating mutants with enhanced bacterial blight resistance while maintaining normal growth and yield.
Rundong Shen, Xinbo Li, Yaqi Zhang, Liying Ding, Yongzhen Pang, Kexuan Tang   +5 more
wiley   +1 more source

The TaRNS4–TaPP2C10 module regulates wheat resistance to stripe rust through RNA degradation and MAPK cascades

Journal of Integrative Plant Biology, EarlyView.
In wheat, phosphorylation of the S‐like RNase TaRNS4 mediated by the kinase TaRLK5 promotes its degradation of Puccinia striiformis f. sp. tritici RNA in the apoplast, enhancing resistance to stripe rust. TaRNS4 can hijack phosphatase TaPP2C10 to relieve its dephosphorylation of TaMAPK6, thereby activating MAPK‐mediated immune responses. ABSTRACT RNase
Qiao Wang, Hongxu Zuo, Mantong Lu, Ying Li, Juan Li, Ming Qin, Peng Cheng, Qiang Li, Baotong Wang   +8 more
wiley   +1 more source

Similarities Between the Lipid Profiles of Skin and Liver of European Sea Bass (Dicentrarchus labrax) Fed Diets With Different Lipid Content

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT The fatty acid composition of fish is influenced by species, age, diet, and tissues, which respond differently to dietary lipids. This study examined how two commercial diets with contrasting polyunsaturated fatty acid (PUFA) profiles, affecting eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), alter the fatty acid composition in ...
Daniel González‐Silvera, Cristóbal Espinosa‐Ruiz, M. Ángeles Esteban   +2 more
wiley   +1 more source

Effect of Salinity Stress on Growth, Omega-3 Accumulation, and Desaturase Gene Expression in Spirogyra sp.

Hayati Journal of Biosciences
Salinity is well known to enhance omega-3 biosynthesis in marine algae. However, the effect of salinity on freshwater algae, Spirogyra sp., remains unexplored.
Ririn Ananda Samarlina, Husna Nugrahapraja, Erly Marwani   +2 more
doaj   +1 more source