Results 221 to 230 of about 84,621 (282)

Based on artificial intelligence-assisted generation and in-depth in-silico evaluation of potential inhibitors targeting Stearoyl-CoA desaturase 1 (SCD-1). [PDF]

Sci Rep
Wang Q, Deng B, Chen JQ, Jiang H, Liang Z.   +4 more
europepmc   +1 more source

Double defense: enhancing tobacco with cyanobacterial and thaumatin genes. [PDF]

Front Bioeng Biotechnol
Kyrpa T, Prokhorova Y, Kharkhota M, Kuchuk M.   +3 more
europepmc   +1 more source

Engineering <i>Yarrowia lipolytica</i> for nervonic acid production by organelle compartmentalization and dynamic promoter coordination. [PDF]

Synth Syst Biotechnol
Ye S, He W, Yang N, He Q, Zhou J, Xia Y.
europepmc   +1 more source

Stearoyl-CoA desaturase 5 (SCD5) in lipid remodeling: From molecular control to pathophysiology. [PDF]

J Lipid Res
Zámbó V, Orosz G, Csala M, Kereszturi É.   +3 more
europepmc   +1 more source

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Yeast desaturases

Biochemical Society Transactions, 2002
The Saccharomyces OLE1 gene encodes the intrinsic membrane-bound Δ-9 fatty acid desaturase. OLE1 expression is regulated at the levels of transcription and mRNA stability by nutrient fatty acids and molecular oxygen. Its transcription is controlled through two distinct promoter elements, the fatty acid response element (FAR) region, and a downstream ...
C E, Martin, C-S, Oh, P, Kandasamy, R, Chellapa, M, Vemula   +4 more
openaire   +3 more sources

The evolution of desaturases

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2003
When considering the evolution of desaturases, several different aspects come into focus, the most obvious ones being phylogenetic origins and differentiation of regioselectivities of these enzymes. In this general context the term desaturase includes all enzymes able to activate oxygen and to use this reagent for a subsequent modification of C–H bonds
P, Sperling, P, Ternes, T K, Zank, E, Heinz   +3 more
openaire   +2 more sources

Gene regulation of mammalian desaturases

Biochemical Society Transactions, 2002
Stearoyl-CoA desaturase (SCD) catalyses the synthesis of oleic acid (18:1, n - 9), which is mostly esterified into triacylglycerols (TAGs) as an energy reserve. Δ-6 Desaturase (D6D) and Δ-5 desaturase (D5D) are the key enzymes for the synthesis of highly unsaturated fatty acids (HUFAs), such as arachidonic acid (20:4, n - 6) and docosahexaenoic acid ...
M T, Nakamura, T Y, Nara
openaire   +2 more sources

The Specificity of Mammalian Desaturases

1977
Studies of the metabolism of unsaturated fatty acids by mammals, particularly the rat, have been done over many years both by feeding unlabelled fatty acids followed by analytical and structural studies of the resultant tissue fatty acids and by using labelled substrates in whole animals, individual organs and tissue homogenates.
openaire   +2 more sources

Dihydroceramide Desaturase Activity in Tumors

Biochemistry (Moscow), 2002
Dihydroceramide desaturase activity in the transplantable mouse hepatoma-22, rat hepatoma-27, M1 sarcoma, and RS1 rat cholangiocellular carcinoma has been investigated. It was found that the dihydroceramide desaturase activity in mouse hepatoma-22 is lower than that in normal mouse liver.
A G, Kandyba, V A, Kobliakov, A M, Kozlov, I Yu, Nagaev, V P, Shevchenko, E V, Dyatlovitskaya   +5 more
openaire   +2 more sources

Membrane‐bound phospholipid desaturases

Lipids, 1979
AbstractThis review covers studies on membrane‐bound phospholipid desaturases in yeast and rat liver carried out in this laboratory. In yeast the desaturase system was shown to effect the direct desaturation of dioleoyl‐lecithin to dilinoleoyl‐lecithin.
E L, Pugh, M, Kates
openaire   +2 more sources