Results 1 to 10 of about 18,623 (291)

Desmoglein-4 Deficiency Exacerbates Psoriasiform Dermatitis in Rats While Psoriasis Patients Displayed a Decreased Gene Expression of DSG4

Frontiers in Immunology, 2021
Desmogleins are involved in cell adhesion conferring structural skin integrity. However, their role in inflammation has been barely studied, and whether desmoglein-4 modulates psoriasis lesions is completely unknown. In this study, we assessed the impact
Tamara Moreno-Sosa, María Belén Sánchez, Elisa Olivia Pietrobon, Elisa Olivia Pietrobon, Juan Manuel Fernandez-Muñoz, Felipe Carlos Martín Zoppino, Flavia Judith Neira, María José Germanó, Diego Esteban Cargnelutti, Alicia Carolina Innocenti, Graciela Alma Jahn, Susana Ruth Valdez, Susana Ruth Valdez, Juan Pablo Mackern-Oberti, Juan Pablo Mackern-Oberti   +14 more
doaj   +2 more sources

Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion. [PDF]

PLoS ONE, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of ...
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Spindler, Volker, Vigh, Balázs, Waschke, Jens   +5 more
core   +20 more sources

Factors associated with persistent anti-desmoglein positivity after remission in pemphigus vulgaris: a prospective registry-based cohort study. [PDF]

Front Immunol
IntroductionAnti-desmoglein (Dsg) antibodies are well-established markers correlated with clinical phenotype and disease severity in pemphigus vulgaris (PV).
Zhou Y, Wang Y, Wang M, Zhou X, Luo L, Yan W, Li W.   +6 more
europepmc   +2 more sources

Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study [PDF]

BMC Oral Health
Background Due to the not fully understood exact pathogenesis of oral lichen planus, the patients receive symptomatic management, rather than a curative treatment.
Abdelwadood D, Fouad Y, El-Khazragy N, Amr A.   +3 more
europepmc   +2 more sources

Desmoglein autoantibodies and disease severity in pemphigus patients – correlations and discrepancies [PDF]

Folia Medica, 2023
Aim: To assess the correlation between the levels of anti-desmoglein-1 and anti-desmoglein-3 autoantibodies and disease severity in pemphigus patients.
Zhaneta H. Zhelyazkova, Tsvetana I. Abadjieva, Petya A. Gardjeva, Mariana A. Murdjeva, Tsonka M. Miteva-Katrandzhieva   +4 more
doaj   +3 more sources

Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells. [PDF]

PLoS ONE, 2014
During development and progression of malignant melanoma, an important role has been attributed to alterations of cell-cell adhesions, in particular, to a "cadherin switch" from E- to N-cadherin.
Wiebke K Peitsch, Yvette Doerflinger, Reiner Fischer-Colbrie, Volker Huck, Alexander T Bauer, Jochen Utikal, Sergij Goerdt, Stefan W Schneider   +7 more
doaj   +1 more source

HLA class II antigens in Croatian patients with pemphigus vulgaris and their correlation with anti-desmoglein antibodies

Frontiers in Immunology, 2023
Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. The etiology of PV is multifactorial,
Ines Lakoš Jukić, Ines Lakoš Jukić, Mislav Mokos, Branka Marinović, Branka Marinović   +4 more
doaj   +1 more source

Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study

Van Tıp Dergisi, 2021
INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and
Özge Aşkın, Ayşe Mine Gök, Tuğba Kevser Uzunçakmak, Zekayi Kutlubay   +3 more
doaj   +1 more source

Experience of rituximab therapy in pemphigus: A three-year retrospective study from a Sub-Himalayan State

Indian Journal of Dermatology, 2022
Background: Pemphigus is a group of auto-immune blistering disorders, characterised clinically by mucocutaneous blisters and erosions and histopathologically by intra-epidermal acantholysis.
Ghanshyam Verma, Aditi Sharma, Renu Rattan, Ajeet Negi, Mudita Gupta, Rajni Sharma   +5 more
doaj   +1 more source

Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin

Frontiers in Immunology, 2022
Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt, Julia Pircher, Letyfee Steinert, Katharina Meier, Kamran Ghoreschi, Franziska Vielmuth, Daniela Kugelmann, Jens Waschke   +7 more
doaj   +1 more source