Results 11 to 20 of about 7,325 (186)

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils. [PDF]

Pediatr Allergy Immunol
Abstract Background Eosinophilic esophagitis (EoE) is a chronic allergic disorder driven by type 2 inflammation, characterized by eosinophilic infiltration and esophageal epithelial abnormalities, including barrier dysfunction, basal cell hyperplasia, epithelial thickening, and loss of differentiation.
Gautam R, Lal M, Carroll MC, Mrozek Z, Trachsel T, Beers J, Ruffner MA.   +6 more
europepmc   +2 more sources

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin

Frontiers in Immunology, 2022
Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt, Julia Pircher, Letyfee Steinert, Katharina Meier, Kamran Ghoreschi, Franziska Vielmuth, Daniela Kugelmann, Jens Waschke   +7 more
doaj   +1 more source

Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?

Advanced Biomedical Research, 2016
Background: Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis.
Fariba Iraji, Nabet Tajmirriahi, Iman Momeni, Kioumars Jamshidi, Fazlollah Hashemzehi, Amir Hossein Siadat, Alireza Asemi Esfahani   +6 more
doaj   +1 more source

Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion [PDF]

PLoS ONE, 2013
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed.
Hartlieb, Eva, Kempf, Bettina, Partilla, Miriam, Vigh, Balázs, Spindler, Volker, Waschke, Jens   +5 more
openaire   +5 more sources

Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model

Frontiers in Medicine, 2022
Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3.
Uta Katharina Radine, Valéria Bumiller-Bini Hoch, Valéria Bumiller-Bini Hoch, Angelica B. Winter Boldt, Detlef Zillikens, Detlef Zillikens, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christoph M. Hammers, Christoph M. Hammers, Christoph M. Hammers, Matthias Klinger, Jennifer E. Hundt, Jennifer E. Hundt   +14 more
doaj   +1 more source

Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up

Clinical and Developmental Immunology, 2009
The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them.
Anna Belloni-Fortina, Diana Faggion, Barbara Pigozzi, Andrea Peserico, Matteo Bordignon, Vincenzo Baldo, Mauro Alaibac   +6 more
doaj   +1 more source

Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic

Biomedicines, 2021
Pemphigus is a rare autoimmune disease characterised by the production of pathogenic autoantibodies in response to different desmosome proteins. The pathophysiological process leads to the development of blisters and erosions on mucosal and/or skin ...
Branka Marinović, Joško Miše, Ines Lakoš Jukić, Zrinka Bukvić Mokos   +3 more
doaj   +1 more source

Anti-Desmocollin Autoantibodies in Autoimmune Blistering Diseases

Frontiers in Immunology, 2021
The presence of anti-desmocollin (Dsc) antibodies is rarely described in autoimmune blistering diseases patients. Moreover, several clinical phenotypes of pemphigus may be associated with these antibodies.
Xavier Bosch-Amate, Pilar Iranzo, Marta Ivars, José Manuel Mascaró Galy, Agustín España   +4 more
doaj   +1 more source

Desmoglein-1, differentiation, and disease [PDF]

Journal of Clinical Investigation, 2013
Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
Christoph M, Hammers, John R, Stanley
openaire   +2 more sources