Results 11 to 20 of about 18,623 (291)

Detection of anti-desmoglein antibodies in oral lichen planus: What do we know so far

Frontiers in Immunology, 2022
Oral lichen planus (OLP) is an inflammatory disease of the oral mucosa. Clinically, two main subsets are described, namely non-erosive and erosive OLP. While non-erosive OLP is usually responsive to local therapies, erosive OLP is often refractory also ...
Dario Didona, Michael Hertl
doaj   +2 more sources

Synergy among non-desmoglein antibodies contributes to the immunopathology of desmoglein antibody–negative pemphigus vulgaris [PDF]

Journal of Biological Chemistry, 2019
Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by IgG autoantibodies (AuAbs) binding to epidermal keratinocytes and inducing this devastating disease.
A. Chernyavsky, K. Amber, A. Agnoletti, Candice Wang, S. Grando   +4 more
semanticscholar   +6 more sources

Epithelial barrier dysfunction in desmoglein-1 deficiency. [PDF]

Journal of Allergy and Clinical Immunology, 2018
Mutations in the desmoplakin (DSP) and desmoglein-1 (DSG1) genes have been implicated in patients with the inherited inflammatory skin disease known as severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome (MIM#603165, see Tables E1 and E2 in this article's Online Repository at www.jacionline.org).1, 2 The DSP and DSG1 genes ...
L. Polivka, S. Hadj-Rabia, E. Bal, S. Leclerc‐Mercier, M. Madrange, Y. Hamel, D. Bonnet, S. Mallet, H. Lepidi, C. Ovaert, P. Barbet, C. Dupont, B. Neven, A. Munnich, L. Godsel, F. Campeotto, R. Weil, E. Laplantine, S. Marchetto, J. Borg, W. Weis, J. Casanova, A. Puel, K. Green, C. Bodemer, A. Smahi   +25 more
semanticscholar   +4 more sources

Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover. [PDF]

Journal of Biological Chemistry, 2016
Desmosomes are prominent adhesive junctions present between many epithelial cells as well as cardiomyocytes. The mechanisms controlling desmosome assembly and remodeling in epithelial and cardiac tissue are poorly understood.
Johnson, Keith R., Kowalczyk, Andrew P., Lewis, Joshua D., Mahoney, My G., Overmiller, Andrew M., Roberts, Brett J., Svoboda, Robert A., Wahl, James K.   +7 more
core   +3 more sources

Non-Desmoglein Antibodies in Patients With Pemphigus Vulgaris

Frontiers in Immunology, 2018
Pemphigus vulgaris (PV) is a potentially life-threatening mucocutaneous autoimmune blistering disease. Patients develop non-healing erosions and blisters due to cell–cell detachment of keratinocytes (acantholysis), with subsequent suprabasal ...
K. Amber, Manuel Valdebran, S. Grando
semanticscholar   +6 more sources

Keratins Regulate p38MAPK-Dependent Desmoglein Binding Properties in Pemphigus

Frontiers in Immunology, 2018
Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly ...
Franziska Vielmuth, Elias Walter, Michael Fuchs, Mariya Y. Radeva, Fanny Buechau, Thomas M. Magin, Volker Spindler, Jens Waschke   +7 more
doaj   +2 more sources

Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein compensation hypothesis, namely that one desmoglein can compensate for loss of function of another, has been proposed to explain the tissue specificity of the autoantibody-induced loss of cell adhesion in pemphigus. To validate this hypothesis genetically, we used desmoglein-3 knockout mice (DSG3-/-) that lose their telogen hair ...
Yasushi Hanakawa, Norihisa Matsuyoshi, John R. Stanley   +2 more
openalex   +4 more sources

Investigation of SNPs in the porcine desmoglein 1 gene [PDF]

BMC Veterinary Research, 2007
Background Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus. The exfoliative toxins produced by S.
Andresen Lars, Daugaard Lise, Fredholm Merete   +2 more
doaj   +5 more sources

T Lymphocytes from a Subset of Patients with Pemphigus Vulgaris Respond to Both Desmoglein-3 and Desmoglein-1

Journal of Investigative Dermatology, 1997
Pemphigus vulgaris and pemphigus foliaceus are cutaneous autoimmune diseases characterized by intraepithelial blisters and autoantibodies to desmosomal glycoproteins. The antigens recognized by pemphigus vulgaris and pemphigus foliaceus autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectively.
Mong-Shang Lin, Sue J. Swartz, Argelia Lopez, Xiang Ding, Janet A. Fairley, Luis A. Díaz   +5 more
openalex   +4 more sources

Desmogleins and Desmocollins as Adhesive Molecules [PDF]

Journal of Investigative Dermatology, 2007
Following the identification of desmoglein and desmocollins as the transmembrane components of the desmosome, sequence analysis re vealed that they are members of the cadherin family of cell–cell adhesion molecules. Cadherins are characterized by the presence of conserved extracellular calcium-binding motifs.
James K. Wahl
openalex   +5 more sources