Results 21 to 30 of about 18,623 (291)

Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus?

Cells, 2022
Pemphigus vulgaris is an autoimmune blistering disease of the epidermis, caused by autoantibodies against desmosomal proteins, mainly desmogleins 1 and 3, which induce an impairment of desmosomal adhesion and blister formation. Recent findings have shown
A. Zakrzewicz, C. Würth, B. Beckert, S. Feldhoff, K. Vanderheyden, Stian Foss, J. Andersen, H. Haard, P. Verheesen, V. Bobkov, R. Tikkanen   +10 more
semanticscholar   +1 more source

The interaction between Staphylococcus aureus SdrD and desmoglein 1 is important for adhesion to host cells [PDF]

Scientific Reports, 2016
Staphylococcus aureus is known as a frequent colonizer of the skin and mucosa. Among bacterial factors involved in colonization are adhesins such as the microbial surface components recognizing adhesive matrix molecules (MSCRAMMs).
Ajayi, Clement, Askarian, Fatemeh, Diep, Dzung Bao, Hanssen, Anne-Merethe, Johannessen, Mona, Pettersen, ingvild, Sollid, Johanna U Ericson, Van Sorge, Nina M.   +7 more
core   +4 more sources

Desmoglein compensation hypothesis fidelity assessment in Pemphigus

Frontiers in Immunology, 2022
The pemphigus group of autoimmune blistering diseases encompasses pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Lesion location in pemphigus has been elegantly postulated by the Desmoglein Compensation Hypothesis (DCH), which references the ...
Lauren Sielski, J. Baker, Michael C. DePasquale, K. Attwood, K. Seiffert-Sinha, A. Sinha   +5 more
semanticscholar   +1 more source

Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice.

European Heart Journal, 2021
AIMS Arrhythmogenic cardiomyopathy (ACM) is characterized by progressive loss of cardiomyocytes, and fibrofatty tissue replacement. Extracellular vesicles (EVs) secreted by cardiosphere-derived cells, immortalized, and engineered to express high levels ...
Yen-Nien Lin, T. Mesquita, L. Sanchez, Yin-Huei Chen, Weixin Liu, Chang Li, R. Rogers, Yizhou Wang, Xinling Li, Di Wu, Rui Zhang, A. Ibrahim, E. Marbán, E. Cingolani   +13 more
semanticscholar   +1 more source

Rituximab in Pemphigus Foliaceous With Autoantibodies Against Both Desmoglein 1 and Desmoglein 3 [PDF]

European Journal of Dermatology, 2011
ejd.2011.1288 Auteur(s) : Rodrigo CARVALHO1 rodrigoaraujocarvalho@gmail.com, Paula MAIO1, Daniela CUNHA1, Isabel FREITAS1, Ana AFONSO2, Jorge CARDOSO1 1 Department of Dermatology and Venereology, Curry Cabral Hospital, Lisbon, Portugal 2 Department of Pathology, Curry Cabral Hospital, Lisbon, Portugal Reprints.: R. CARVALHO Pemphigus foliaceous (PF) is
Afonso, A, Cardoso, J, Carvalho, R, Cunha, D, Freitas, I, Maio, P   +5 more
core   +3 more sources

FcRn Antagonism Leads to a Decrease of Desmoglein-Specific B Cells: Secondary Analysis of a Phase 2 Study of Efgartigimod in Pemphigus Vulgaris and Pemphigus Foliaceus

Frontiers in Immunology, 2022
Background Immunoglobulin G (IgG) levels are maintained by the IgG-recycling neonatal Fc-receptor (FcRn). Pemphigus vulgaris and pemphigus foliaceus are debilitating autoimmune disorders triggered by IgG autoantibodies against mucosal and epidermal ...
M. Maho-Vaillant, M. Sips, M. Golinski, G. Vidarsson, M. Goebeler, J. Stoevesandt, Z. Bata-Csörgő, Bianca Balbino, P. Verheesen, P. Joly, M. Hertl, S. Calbo   +11 more
semanticscholar   +1 more source

Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC

Journal of Clinical Medicine, 2021
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive heart condition which causes fibro-fatty myocardial scarring, ventricular arrhythmias, and sudden cardiac death.
Robert N Hawthorne, A. Blazeski, Justin Lowenthal, Suraj Kannan, R. Teuben, D. Disilvestre, Justin Morrissette-McAlmon, J. Saffitz, K. Boheler, C. James, S. Chelko, G. Tomaselli, L. Tung   +12 more
semanticscholar   +1 more source

Phenotypic recapitulation and correction of desmoglein-2-deficient cardiomyopathy using human-induced pluripotent stem cell-derived cardiomyocytes

Human Molecular Genetics, 2021
Desmoglein-2, encoded by DSG2, is one of the desmosome proteins that maintain the structural integrity of tissues, including heart. Genetic mutations in DSG2 cause arrhythmogenic cardiomyopathy, mainly in an autosomal dominant manner. Here, we identified
Mikio Shiba, Shuichiro Higo, Takumi Kondo, Junjun Li, Li Liu, Y. Ikeda, Yasuaki Kohama, Satoshi Kameda, Tomoka Tabata, Hiroyuki Inoue, Satoki Nakamura, M. Takeda, E. Ito, S. Takashima, S. Miyagawa, Y. Sawa, S. Hikoso, Y. Sakata   +17 more
semanticscholar   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy

Cell and Tissue Research, 2021
The study of a desmoglein 2 murine model of arrhythmogenic cardiomyopathy revealed cardiac inflammation as a key early event leading to fibrosis. Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disorder leading to ventricular arrhythmias ...
K. Ng, P. Delaney, D. Thenet, S. Murtough, C. Webb, N. Zaman, E. Tsisanova, G. Mastroianni, S. Walker, J. Westaby, D. Pennington, R. Pink, D. Kelsell, A. Tinker   +13 more
semanticscholar   +1 more source