Results 31 to 40 of about 18,623 (291)

Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells

Cell Communication and Signaling, 2021
High temperature requirement A (HtrA) is an active serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric epithelial ...
Sabine Bernegger, R. Vidmar, M. Fonović, Gernot Posselt, B. Turk, S. Wessler   +5 more
semanticscholar   +1 more source

Mutations in desmoglein-1 cause diverse inherited palmoplantar keratoderma phenotypes:implications for genetic screening [PDF]

British Journal of Dermatology, 2017
The inherited palmoplantar keratodermas (PPKs) are a heterogeneous group of genodermatoses, characterized by thickening of the epidermis of the palms and soles. No classification system satisfactorily unites clinical presentation, pathology and molecular
Almutawa, Armstrong, Dua-Awereh, Harmon, Has, Hershkovitz, Hunt, Irvine, Itin, Keren, Klijuic, McAleer, Milingou, Nomura, Samuelov, Wan, Whittock   +16 more
core   +3 more sources

Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Koji Sayama, Yoko Yahata, Masayuki Amagai, Mikiko Tohyama, Yuji Shirakata, Sho Tokumaru, Koji Hashimoto, Kenshi Yamasaki, Yasushi Hanakawa   +8 more
openaire   +3 more sources

Desmoglein 1 and Desmoglein 3 Are the Target Autoantigens in Herpetiform Pemphigus [PDF]

Archives of Dermatology, 1999
To determine the cell surface autoimmune target of herpetiform pemphigus (HP).Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg.Twenty serum samples were obtained from patients
Takashi Hashimoto, Takeji Nishikawa, Masayuki Amagai, Stefania Jabłońska, Tamotsu Ebihara, Tadeusz P. Chorzelski, Ayako Komai, Ken Ishii, Kazuhiko Ohya   +8 more
openaire   +3 more sources

A Subset of Pemphigus Foliaceus Patients Exhibits Pathogenic Autoantibodies Against Both Desmoglein-1 and Desmoglein-3 [PDF]

Journal of Investigative Dermatology, 2002
In pemphigus vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease. Development of cutaneous disease is associated with acquisition of antibodies to desmoglein-1. In pemphigus foliaceus, and its endemic form, fogo selvagem by contrast, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease
Luis Arteaga, Philip Prisayanh, Simon Warren, Zhi Liu, Luis A. Díaz, Mong-Shang Lin   +5 more
openalex   +5 more sources

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Identification of Desmogleins as Disease Targets [PDF]

Journal of Investigative Dermatology, 2007
While it had long been known that desmosomes were crucial for interconnecting cells in laboratory experiments, the link between desmosomal adhesion and human health was bolstered by several key experiments demonstrating that desmogleins were targeted in both autoimmune and infectious diseases.
Cory L. Simpson, Kathleen J. Green
openaire   +4 more sources

Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model

Frontiers in Medicine, 2022
Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3.
Uta Katharina Radine, Valéria Bumiller-Bini Hoch, Valéria Bumiller-Bini Hoch, Angelica B. Winter Boldt, Detlef Zillikens, Detlef Zillikens, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christoph M. Hammers, Christoph M. Hammers, Christoph M. Hammers, Matthias Klinger, Jennifer E. Hundt, Jennifer E. Hundt   +14 more
doaj   +1 more source

Anti-Desmocollin Autoantibodies in Autoimmune Blistering Diseases

Frontiers in Immunology, 2021
The presence of anti-desmocollin (Dsc) antibodies is rarely described in autoimmune blistering diseases patients. Moreover, several clinical phenotypes of pemphigus may be associated with these antibodies.
Xavier Bosch-Amate, Pilar Iranzo, Marta Ivars, José Manuel Mascaró Galy, Agustín España   +4 more
doaj   +1 more source

Pemphigus—The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic

Biomedicines, 2021
Pemphigus is a rare autoimmune disease characterised by the production of pathogenic autoantibodies in response to different desmosome proteins. The pathophysiological process leads to the development of blisters and erosions on mucosal and/or skin ...
Branka Marinović, Joško Miše, Ines Lakoš Jukić, Zrinka Bukvić Mokos   +3 more
doaj   +1 more source