Results 1 to 10 of about 12,405 (225)

Desmoglein-1 Deficiency Mimicking Omenn Syndrome

Indian Journal of Dermatology
Meltem Comert, Tugba Guler, Ayca Ceylan, İlknur Kulhas Celik, Pinar Karabagli, Tulin Cora, Hasibe Artac   +6 more
doaj   +5 more sources

Evaluation of desmoglein 1 and desmoglein 3 autoantibodies in oral cancer: A pilot study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis.
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Raghurama Rao Gandikota, Y Sandhya Pavankumar, Divya Uppala   +4 more
doaj   +3 more sources

Detection of Autoantibodies against Recombinant Desmoglein 1 and 3 Molecules in Patients with Pemphigus vulgaris: Correlation with Disease Extent at the Time of Diagnosis and during Follow-Up [PDF]

Clinical and Developmental Immunology, 2009
The recent availability of cDNA clones for pemphigus antigens has allowed the production of recombinant desmoglein 1 and desmoglein 3 molecules and the development of an ELISA approach in order to determine levels of antibodies to them.
Anna Belloni-Fortina, Diana Faggion, Barbara Pigozzi, Andrea Peserico, Matteo Bordignon, Vincenzo Baldo, Mauro Alaibac   +6 more
doaj   +6 more sources

IgA pemphigus showing IgA antibodies to desmoglein 1 and 3 [PDF]

Dermatology Practical & Conceptual, 2016
Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).
Salama Hegazy, Sana Bouchouicha, Aida Khaled, Lilia Laadher, Maryem Kallel Sellami, Faten Zeglaoui   +5 more
doaj   +4 more sources

Long-lasting localized pemphigus vulgaris without detectable serum autoantibodies against desmoglein 3 and desmoglein 1

Indian Journal of Dermatology, 2016
Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area.
Asuka Yoshifuku, Kazuyasu Fujii, Hisao Kawahira, Hiromi Katsue, Atsunori Baba, Yuko Higashi, Yumi Aoyama, Takuro Kanekura   +7 more
doaj   +5 more sources

Investigation of SNPs in the porcine desmoglein 1 gene [PDF]

BMC Veterinary Research, 2007
Background Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus. The exfoliative toxins produced by S.
Andresen Lars, Daugaard Lise, Fredholm Merete   +2 more
doaj   +5 more sources

Epithelial barrier dysfunction in desmoglein-1 deficiency [PDF]

Journal of Allergy and Clinical Immunology, 2018
Mutations in the desmoplakin (DSP) and desmoglein-1 (DSG1) genes have been implicated in patients with the inherited inflammatory skin disease known as severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome (MIM#603165, see Tables E1 and E2 in this article's Online Repository at www.jacionline.org).1, 2 The DSP and DSG1 genes ...
Polivka, Laura, Hadj-Rabia, Smaïl, Bal, Elodie, Leclerc-Mercier, Stéphanie, Madrange, Marine, Hamel, Yamina, Bonnet, Damien, Mallet, Stéphanie, Lepidi, Hubert, Ovaert, Caroline, Barbet, Patrick, Dupont, Christophe, Neven, Bénédicte, Munnich, Arnold, Godsel, Lisa, Campeotto, Florence, Weil, Robert, Laplantine, Emmanuel, Marchetto, Sylvie, Borg, Jean-Paul, Weis, William, Casanova, Jean-Laurent, Puel, Anne, Green, Kathleen, Bodemer, Christine, Smahi, Asma   +25 more
openaire   +4 more sources

Rituximab in Pemphigus Foliaceous With Autoantibodies Against Both Desmoglein 1 and Desmoglein 3 [PDF]

European Journal of Dermatology, 2011
ejd.2011.1288 Auteur(s) : Rodrigo CARVALHO1 rodrigoaraujocarvalho@gmail.com, Paula MAIO1, Daniela CUNHA1, Isabel FREITAS1, Ana AFONSO2, Jorge CARDOSO1 1 Department of Dermatology and Venereology, Curry Cabral Hospital, Lisbon, Portugal 2 Department of Pathology, Curry Cabral Hospital, Lisbon, Portugal Reprints.: R. CARVALHO Pemphigus foliaceous (PF) is
Afonso, A, Cardoso, J, Carvalho, R, Cunha, D, Freitas, I, Maio, P   +5 more
core   +3 more sources

Desmoglein-1, differentiation, and disease [PDF]

Journal of Clinical Investigation, 2013
Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
John R. Stanley, Christoph M. Hammers
openaire   +4 more sources

Pemphigus Foliaceus Autoantibodies Induce Redistribution Primarily of Extradesmosomal Desmoglein 1 in the Cell Membrane [PDF]

Frontiers in Immunology, 2022
The autoimmune dermatosis pemphigus foliaceus (PF) is predominantly caused by IgG autoantibodies against the desmosomal cadherin desmoglein (Dsg) 1. The exact mechanisms that lead to the characteristic epidermal blistering are not yet fully understood ...
Matthias Hiermaier, Daniela Kugelmann, Mariya Y. Radeva, Dario Didona, Kamran Ghoreschi, Kamran Ghoreschi, Solimani Farzan, Michael Hertl, Jens Waschke   +8 more
doaj   +2 more sources