Results 1 to 10 of about 7,081 (178)
Desmoglein-1 Deficiency Mimicking Omenn Syndrome [PDF]
Indian Journal of DermatologyMeltem Comert +6 more
doaj +4 more sources
IgA pemphigus showing IgA antibodies to desmoglein 1 and 3 [PDF]
Dermatology Practical & Conceptual, 2016 Background: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).
Salama Hegazy +5 more
doaj +5 more sources
Evaluation of desmoglein 1 and desmoglein 3 autoantibodies in oral cancer: A pilot study
Journal of Indian Academy of Oral Medicine and Radiology, 2023 Background: Carcinogenesis is a complex multistep process involving alterations at the cellular level. Alteration in cell-to-cell adhesion of oral epithelium plays an important role in carcinogenesis and metastasis.
Pavan Kumar Yellarthi +4 more
doaj +2 more sources
Epidermal stratification requires retromer-mediated desmoglein-1 recycling. [PDF]
Dev Cell, 2022 Sorting transmembrane cargo is essential for tissue development and homeostasis. However, mechanisms of intracellular trafficking in stratified epidermis are poorly understood. Here, we identify an interaction between the retromer endosomal trafficking component, VPS35, and the desmosomal cadherin, desmoglein-1 (Dsg1). Dsg1 is specifically expressed in
Hegazy M +10 more
europepmc +3 more sources
Ultrastructural skin alterations of healthy subjects with anti-desmoglein 1 antibodies in endemic areas to pemphigus foliaceus: A case series [PDF]
Journal of Translational Autoimmunity, 2023 Background: Endemic pemphigus foliaceus and endemic pemphigus vulgaris are autoimmune dermatologic disorders endemic to the Peruvian Amazon. Objective: To determine the ultrastructural skin alterations of three healthy subjects with anti DSG-1 antibodies
Willy Ramos +10 more
doaj +2 more sources
Indian Journal of Dermatology, 2016 Pemphigus vulgaris (PV) is an autoimmune blistering disease elicited by anti-desmoglein (DsG) 3 antibody. Although skin lesions tend to be distributed over the entire body, in some patients, they are confined to a restricted area.
Asuka Yoshifuku +7 more
doaj +3 more sources
Desmoglein-1, differentiation, and disease. [PDF]
J Clin Invest, 2013 Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
Hammers CM, Stanley JR.
europepmc +4 more sources
Investigation of SNPs in the porcine desmoglein 1 gene [PDF]
BMC Veterinary Research, 2007 Background Desmoglein 1 (DSG1) is the target protein in the skin disease exudative epidermitis in pigs caused by virulent strains of Staphylococcus hyicus. The exfoliative toxins produced by S.
Andresen Lars +2 more
doaj +4 more sources
Endocytosis of IgG, Desmoglein 1, and Plakoglobin in Pemphigus Foliaceus Patient Skin [PDF]
Frontiers in Immunology, 2019 Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin.
Dyah A. M. Oktarina +5 more
doaj +2 more sources
Epithelial barrier dysfunction in desmoglein-1 deficiency. [PDF]
J Allergy Clin Immunol, 2018 Mutations in the desmoplakin (DSP) and desmoglein-1 (DSG1) genes have been implicated in patients with the inherited inflammatory skin disease known as severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome (MIM#603165, see Tables E1 and E2 in this article's Online Repository at www.jacionline.org).1, 2 The DSP and DSG1 genes ...
Polivka L +25 more
europepmc +4 more sources