Results 11 to 20 of about 12,405 (225)

A role for caveolin-1 in desmoglein binding and desmosome dynamics. [PDF]

Oncogene, 2011
Desmoglein-2 (Dsg2) is a desmosomal cadherin that is aberrantly expressed in human skin carcinomas. In addition to its well-known role in mediating intercellular desmosomal adhesion, Dsg2 regulates mitogenic signaling that may promote cancer development ...
Brennan, D, Del Galdo, F, Dowling, A, Green, K J, Mahoney, M G, Medhat, W, Peltonen, S, Wahl, J K   +7 more
core   +9 more sources

A Systematic Review on the Role of Desmoglein 1 and Desmoglein 3 in Etiopathogenesis and Metastasis of Oral Cancer

Journal of Indian Academy of Oral Medicine and Radiology
Background: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration.
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Gandikota Raghurama Rao, Sandhya Pavankumar, Divya Uppala   +4 more
doaj   +3 more sources

Expression of Desmoglein 1 Compensates for Genetic Loss of Desmoglein 3 in Keratinocyte Adhesion [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein compensation hypothesis, namely that one desmoglein can compensate for loss of function of another, has been proposed to explain the tissue specificity of the autoantibody-induced loss of cell adhesion in pemphigus. To validate this hypothesis genetically, we used desmoglein-3 knockout mice (DSG3-/-) that lose their telogen hair ...
John R. Stanley, Yasushi Hanakawa, Norihisa Matsuyoshi   +2 more
openaire   +4 more sources

A Subset of Pemphigus Foliaceus Patients Exhibits Pathogenic Autoantibodies Against Both Desmoglein-1 and Desmoglein-3 [PDF]

Journal of Investigative Dermatology, 2002
In pemphigus vulgaris the major pathogenic antibody binds desmoglein-3, and mediates mucosal disease. Development of cutaneous disease is associated with acquisition of antibodies to desmoglein-1. In pemphigus foliaceus, and its endemic form, fogo selvagem by contrast, the major pathogenic antibody recognizes desmoglein-1 and mediates cutaneous disease
Zhi Liu, Luis A. Arteaga, Simon Warren, Mong Shang Lin, Philip S. Prisayanh, Luis A. Diaz   +5 more
  +7 more sources

Pemphigus foliaceus IgG causes dissociation of desmoglein 1–containing junctions without blocking desmoglein 1 transinteraction [PDF]

Journal of Clinical Investigation, 2005
Autoantibodies against the epidermal desmosomal cadherins desmoglein 1 (Dsg1) and Dsg3 have been shown to cause severe to lethal skin blistering clinically defined as pemphigus foliaceus (PF) and pemphigus vulgaris (PV). It is unknown whether antibody-induced dissociation of keratinocytes is caused by direct inhibition of Dsg1 transinteraction or by ...
Detlev Drenckhahn, Paola Bruggeman, Detlef Zillikens, Jens Waschke, Werner Baumgartner   +4 more
openaire   +3 more sources

T Lymphocytes from a Subset of Patients with Pemphigus Vulgaris Respond to Both Desmoglein-3 and Desmoglein-1

Journal of Investigative Dermatology, 1997
Pemphigus vulgaris and pemphigus foliaceus are cutaneous autoimmune diseases characterized by intraepithelial blisters and autoantibodies to desmosomal glycoproteins. The antigens recognized by pemphigus vulgaris and pemphigus foliaceus autoantibodies are desmoglein-3 (Dsg3) and desmoglein-1 (Dsg1), respectively.
Luis A. Diaz, Luis A. Diaz, Janet A. Fairley, Janet A. Fairley, Mong Shang Lin, Sue J. Swartz, Argelia Lopez, Xiang Ding   +7 more
openaire   +4 more sources

Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Koji Sayama, Yoko Yahata, Masayuki Amagai, Mikiko Tohyama, Yuji Shirakata, Sho Tokumaru, Koji Hashimoto, Kenshi Yamasaki, Yasushi Hanakawa   +8 more
openaire   +4 more sources

Endocytosis of IgG, Desmoglein 1, and Plakoglobin in Pemphigus Foliaceus Patient Skin [PDF]

Frontiers in Immunology, 2019
Pemphigus foliaceus (PF) is one of the two main forms of pemphigus and is characterized by circulating IgG to the desmosomal cadherin desmoglein 1 (DSG1) and by subcorneal blistering of the skin.
Dyah A. M. Oktarina, Dyah A. M. Oktarina, Ena Sokol, Duco Kramer, Marcel F. Jonkman, Hendri H. Pas   +5 more
doaj   +2 more sources

The Anti-Desmoglein 1 Autoantibodies in Pemphigus Vulgaris Sera are Pathogenic [PDF]

Journal of Investigative Dermatology, 1999
Pemphigus vulgaris and pemphigus foliaceus are two closely related, but clinically and histologically distinct, autoimmune skin diseases. The autoantigens for pemphigus vulgaris and pemphigus foliaceus are desmoglein 3 and desmoglein 1, respectively. The anti-desmoglein 1 antibodies in pemphigus foliaceus and anti-desmoglein 3 antibodies in pemphigus ...
George J. Giudice, Luis A. Diaz, Luis A. Diaz, Janet A. Fairley, Janet A. Fairley, Xiang Ding, Zhi Liu   +6 more
openaire   +4 more sources

Circulating Antibodies Against DSG1 and DSG3 in Patients with Oral Lichen Planus: A Scoping Review [PDF]

Antibodies
Oral Lichen Planus (OLP) is a chronic autoimmune disease with potential overlap with Pemphigus Vulgaris (PV), particularly in erosive forms. Desmoglein 1 and 3 are transmembrane glycoproteins of desmosomes, typically involved in PV.
Domenico De Falco, Francesca Iaquinta, Doriana Pedone, Alberta Lucchese, Dario Di Stasio, Massimo Petruzzi   +5 more
doaj   +2 more sources