Results 21 to 30 of about 13,090 (254)

Pemphigus IgG Causes Skin Splitting in the Presence of Both Desmoglein 1 and Desmoglein 3 [PDF]

The American Journal of Pathology, 2007
According to the desmoglein (Dsg) compensation concept, different epidermal cleavage planes observed in pemphigus vulgaris and pemphigus foliaceus have been proposed to be caused by different autoantibody profiles against the desmosomal proteins Dsg 1 and Dsg 3.
Volker Spindler, Detlev Drenckhahn, Detlef Zillikens, Jens Waschke   +3 more
openalex   +4 more sources

Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients [PDF]

Experimental Dermatology, 2010
Enno Schmidt, Sandra Saschenbrecker, Takashi Hashimoto   +2 more
exaly   +2 more sources

Desmoglein-1, differentiation, and disease. [PDF]

J Clin Invest, 2013
Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the JCI, Harmon et al.
Hammers CM, Stanley JR.
europepmc   +4 more sources

Paraneoplastic pemphigus without antibodies to desmoglein 1 and [PDF]

Dermatology Online Journal, 2018
Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions ...
Kelsey S. Flood, Christopher M Stroud, Zelmira Lazarov, Nadarajah Vigneswara, Sylvia Hsu   +4 more
openalex   +4 more sources

Plakophilin 1 but not plakophilin 3 regulates desmoglein clustering

Cellular and Molecular Life Sciences, 2019
Plakophilins (Pkp) are desmosomal plaque proteins crucial for desmosomal adhesion and participate in the regulation of desmosomal turnover and signaling. However, direct evidence that Pkps regulate clustering and molecular binding properties of desmosomal cadherins is missing. Here, keratinocytes lacking either Pkp1 or 3 in comparison to wild type (wt)
Michael Fuchs, Marco Foresti, Mariya Y. Radeva, Daniela Kugelmann, René Keil, Meçhthild Hatzfeld, Volker Spindler, Jens Waschke, Franziska Vielmuth   +8 more
openalex   +4 more sources

HLA class II antigens in Croatian patients with pemphigus vulgaris and their correlation with anti-desmoglein antibodies

Frontiers in Immunology, 2023
Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and desmoglein 3, leading to acantholysis. The etiology of PV is multifactorial,
Ines Lakoš Jukić, Ines Lakoš Jukić, Mislav Mokos, Branka Marinović, Branka Marinović   +4 more
doaj   +1 more source

Efficacy of Rituximab in Patients with Autoimmune Bullous Disease: A Retrospective Cohort Study

Van Tıp Dergisi, 2021
INTRODUCTION: The aim of this study was to evaluate the effectiveness of rituximab in autoimmune bullous diseases. METHODS: In this study, the data of patients who received rituximab treatment for autoimmune bullous disease in our clinic between 2012 and
Özge Aşkın, Ayşe Mine Gök, Tuğba Kevser Uzunçakmak, Zekayi Kutlubay   +3 more
doaj   +1 more source

Epithelial barrier dysfunction in desmoglein-1 deficiency. [PDF]

J Allergy Clin Immunol, 2018
Mutations in the desmoplakin (DSP) and desmoglein-1 (DSG1) genes have been implicated in patients with the inherited inflammatory skin disease known as severe dermatitis, multiple allergies, and metabolic wasting (SAM) syndrome (MIM#603165, see Tables E1 and E2 in this article's Online Repository at www.jacionline.org).1, 2 The DSP and DSG1 genes ...
Polivka L, Hadj-Rabia S, Bal E, Leclerc-Mercier S, Madrange M, Hamel Y, Bonnet D, Mallet S, Lepidi H, Ovaert C, Barbet P, Dupont C, Neven B, Munnich A, Godsel LM, Campeotto F, Weil R, Laplantine E, Marchetto S, Borg JP, Weis WI, Casanova JL, Puel A, Green KJ, Bodemer C, Smahi A.   +25 more
europepmc   +4 more sources

Staphylococcal Exfoliative Toxin B Specifically Cleaves Desmoglein 1 [PDF]

Journal of Investigative Dermatology, 2002
Staphylococcal scalded skin syndrome and its localized form, bullous impetigo, show superficial epidermal blister formation caused by exfoliative toxin A or B produced by Staphylococcus aureus. Recently we have demonstrated that exfoliative toxin A specifically cleaves desmoglein 1, a desmosomal adhesion molecule, that when inactivated results in ...
Masayuki Amagai, Koji Nishifuji, Takayuki Yamaguchi, Yasushi Hanakawa, Motoyuki Sugai, John R. Stanley   +5 more
openalex   +3 more sources

Differential Effects of Desmoglein 1 and Desmoglein 3 on Desmosome Formation [PDF]

Journal of Investigative Dermatology, 2002
The desmoglein plays an important part in the formation of desmosomes. We constructed recombinant adenoviruses containing desmoglein 1 and desmoglein 3 derivatives partly lacking the extracellular domain (desmoglein 1DeltaEC and desmoglein 3DeltaEC, respectively), and full-length desmoglein 1 and desmoglein 3 and studied the involvement of desmoglein 1
Hanakawa, Yasushi, Shirakata, Yuji, Yahata, Yoko, Tokumaru, Sho, Yamasaki, Kenshi, Tohyama, Mikiko, Sayama, Koji, Hashimoto, Koji, Amagai, Masayuki   +8 more
openaire   +2 more sources