Results 61 to 70 of about 12,405 (225)

Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells. [PDF]

, 2013
IntroductionThe purpose of this study is to identify target proteins that may play important functional roles in oral cancer stem-like cells (CSCs) using mass spectrometry-based quantitative proteomics.MethodsSphere-formation assays were performed on ...
Feng, Sizhe, Hu, Shen, Liu, Xiaojun, Misuno, Kaori   +3 more
core   +1 more source

Is transition between subtypes of pemphigus possible? A series of pemphigus vulgaris patients showing the transition to pemphigus foliaceus

Anais Brasileiros de Dermatologia, 2023
Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are subtypes of pemphigus with distinct clinical and laboratory features. The transition between these two subtypes has rarely been reported previously.
Rifkiye Kucukoglu, Tugba Atci, Gizem Pinar Sun   +2 more
doaj   +1 more source

Innate immune activation as cofactor in pemphigus disease manifestation

Frontiers in Immunology, 2022
Molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris are subject of current research to date. To decipher the discrepancy between ubiquitous antibody binding to the epidermal desmosomes, but discontinuous disease ...
Ramona A. Eichkorn, Morna F. Schmidt, Elias Walter, Michael Hertl, Jens Malte Baron, Jens Waschke, Amir S. Yazdi, Amir S. Yazdi   +7 more
doaj   +1 more source

c-Src/Cav1-dependent activation of the EGFR by Dsg2. [PDF]

, 2016
The desmosomal cadherin, desmoglein 2 (Dsg2), is deregulated in a variety of human cancers including those of the skin. When ectopically expressed in the epidermis of transgenic mice, Dsg2 activates multiple mitogenic signaling pathways and increases ...
Brennan-Crispi, Donna M., Cooper, Felicia, Deguchi, Takahiro, Mahoney, Mỹ G., McGuinn, Kathleen P., Overmiller, Andrew M., Peltonen, Sirkku, Roberts, Brett J., Wahl, James K.   +8 more
core   +2 more sources

Fogo selvagem: endemic pemphigus foliaceus [PDF]

Anais Brasileiros de Dermatologia, 2018
: Fogo selvagem or endemic pemphigus foliaceus is an autoimmune acantholytic anti-cadherin bullous disease that primarily affects seborrheic areas, which might disseminate.
Günter Hans-Filho, Valéria Aoki, Nelise Ritter Hans Bittner, Guilherme Canho Bittner   +3 more
doaj   +1 more source

Electron microscopy of desmosomal structures in the pemphigus human skin organ culture model

Frontiers in Medicine, 2022
Pemphigus is a chronic autoimmune skin blistering disease, characterized by acantholysis and by the production of autoantibodies directed against the structural desmosomal proteins desmoglein 1 (DSG1) and/or DSG3.
Uta Katharina Radine, Valéria Bumiller-Bini Hoch, Valéria Bumiller-Bini Hoch, Angelica B. Winter Boldt, Detlef Zillikens, Detlef Zillikens, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christoph M. Hammers, Christoph M. Hammers, Christoph M. Hammers, Matthias Klinger, Jennifer E. Hundt, Jennifer E. Hundt   +14 more
doaj   +1 more source

Desmoglein 3: a help or a hindrance in cancer progression? [PDF]

, 2015
Desmoglein 3 is one of seven desmosomal cadherins that mediate cell-cell adhesion in desmosomes. Desmosomes are the intercellular junctional complexes that anchor the intermediate filaments of adjacent cells and confer strong cell adhesion thus are ...
Ambrosch, Attardi, Biscardi, Cavigelli, Foletta, Grosheva, Guarino, Hong Wan, Liu, Louise Brown, Ma, Onishi, Sen, Smeal, Zhurinsky   +14 more
core   +3 more sources

Polypharmacy in mice disrupts left ventricular function and structure and promotes proteome reorganisation in an age‐ and sex‐specific fashion

British Journal of Pharmacology, EarlyView.
Background and Purpose Most older people use polypharmacy (≥5 medications), particularly those with cardiovascular disease. The effects of polypharmacy on the cardiovascular system are not well described. We examined the effect of a chronic polypharmacy regimen on left ventricular (LV) function, structure and proteome in young and old mice of both ...
Trang Tran, Kevin Winardi, Scott P. Levick, Alexander Widiapradja, Gizem Gemikonakli, Susan E. Howlett, Matthew J. McKay, Mark P. Molloy, John Mach, Sarah N. Hilmer   +9 more
wiley   +1 more source

Limbal stem cell transplantation: clinical results, limits, and perspectives [PDF]

, 2018
Limbal stem cell deficiency (LSCD) is a clinical condition characterized by damage of cornea limbal stem cells, which results in an impairment of corneal epithelium turnover and in an invasion of the cornea by the conjunctival epithelium.
Bruscolini, Alice, Lambiase, Alessandro, Rama, Paolo, Sacchetti, Marta   +3 more
core   +1 more source

Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro

International Journal of Cosmetic Science, EarlyView.
Ageing causes actin cytoskeleton disorganization, a reduction in cellular components associated with the actin cytoskeleton and focal adhesions, and a reduction in skin firmness. Galactomyces ferment filtrate boosts actin stability, increases expression of anchoring junction proteins, including focal adhesions and protects against loss of firmness ...
Steph Crabtree, Bradley B. Jarrold, Olivia Kent, Matthew C. Ehrman, Timothy J. Hawkins, Viktor Korolchuk, Camila Pereira Braga, John M. Snowball, Makio Tamura, Tomohiro Hakozaki, Akira Matsubara, John E. Oblong, Max Brown   +12 more
wiley   +1 more source