Results 101 to 110 of about 18,739,280 (231)

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 346, Issue 2, Page 107-127, March 2026.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

024 Comparative analysis of ex vivo assays aimed at identifying Desmoglein 3 reactive CD4+ T cells in pemphigus vulgaris [PDF]

, 2021
Karolin Wieber, Robert Pollmann, Christine L. Zimmer, Dario Didona, Michael Hertl   +4 more
openalex   +1 more source

Sita‐ and saxagliptin use and autoantibodies to autoimmune bullous diseases: A cross‐sectional study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Sören Dräger, Claudia Kauderer, Svenja Meyhöfer, Leonie Dräger, Jens U. Marquardt, Ralf J. Ludwig, Stephan Arndt, Katharina Boch, Katja Bieber   +8 more
wiley   +1 more source

Dupilumab Treatment in Pemphigus: A Report of Three Cases and Literature Review

JEADV Clinical Practice, Volume 5, Issue 1, Page 254-257, March 2026.
Capsule summary Pemphigus vulgaris and foliaceus are rare autoimmune blistering diseases traditionally treated with corticosteroids, immunosuppressants, intravenous immunoglobulins, and rituximab. A subset of patients remains refractory or has contraindications to these conventional therapies. We present three cases of pemphigus treated with dupilumab.
José Javier Mateos Rico, Marta Gutiérrez Pascual, María Dolores Caro Gutiérrez, Cristina Marcos Rodríguez, Javier de Quadros Malagón, Francisco Javier Vicente Martín   +5 more
wiley   +1 more source

Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases

MedComm, Volume 7, Issue 3, March 2026.
This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Shan Cao, Tianyu Wang, Chen Lv, Shanshan Ma, Gongqi Yu, Qianqian Xia, Tingting Liu, Yueqian Yu, Lele Sun, Xiaoyan Pei, Qing Zhao, Zhenzhen Wang, Chuan Wang, Yongxia Liu, Shengli Chen, Jianwen Wang, Guizhi Zhou, Hong Liu, Yonghu Sun, Furen Zhang   +19 more
wiley   +1 more source

Identification of Autoreactive B Cell Subpopulations in Peripheral Blood of Autoimmune Patients With Pemphigus Vulgaris

Frontiers in Immunology, 2019
Pemphigus vulgaris (PV) is a rare blistering disease caused by IgG autoantibodies against the epidermal adhesion molecules desmoglein (Dsg)3 and Dsg1 providing a well-characterized paradigm of an antibody-mediated organ-specific autoimmune disease. In PV
Robert Pollmann, Elias Walter, Thomas Schmidt, Jens Waschke, Michael Hertl, Christian Möbs, Rüdiger Eming   +6 more
doaj   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, Volume 268, Issue 3, Page 249-262, March 2026.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus

Nature Communications
Cell-cell junctions, and specifically desmosomes, are crucial for robust intercellular adhesion. Desmosomal function is compromised in the autoimmune blistering skin disease pemphigus vulgaris.
Henriette Franz, Maitreyi Rathod, Aude Zimmermann, Chiara Stüdle, Vivien Beyersdorfer, Karen Leal-Fischer, Pauline Hanns, Tomás Cunha, Dario Didona, Michael Hertl, Marion Scheibe, Falk Butter, Enno Schmidt, Volker Spindler   +13 more
doaj   +1 more source

A Systematic Review on the Role of Desmoglein 1 and Desmoglein 3 in Etiopathogenesis and Metastasis of Oral Cancer

Journal of Indian Academy of Oral Medicine and Radiology
Background: Desmosomal proteins have a fundamental role in cellular adhesion as they not only maintain cellular homeostasis but also regulate cellular activities like proliferation, differentiation, and migration.
Pavan Kumar Yellarthi, Arvind Muthukrishnan, Gandikota Raghurama Rao, Sandhya Pavankumar, Divya Uppala   +4 more
doaj   +1 more source

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes

Scientific Reports, 2016
Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
F. Völlner, Jawahir Ali, Nina Kurrle, Y. Exner, R. Eming, M. Hertl, A. Banning, R. Tikkanen   +7 more
semanticscholar   +1 more source