Results 71 to 80 of about 7,948 (164)

Loss of cell adhesion in Dsg3bal-Pas mice with homozygous deletion mutation (2079del14) in the desmoglein 3 gene.

open access: yes, 2002
Pemphigus encompasses a group of autoimmune blistering diseases with circulating pathogenic autoantibodies recognizing several proteins, including the desmosomal cadherin, desmoglein 3. Targeted disruption of the Dsg3 gene by homologous recombination (
Pulkkinen, L   +6 more
core  

An Adult Passive Transfer Mouse Model to Study Desmoglein 3 Signaling in Pemphigus Vulgaris

open access: yes, 2012
Evidence has accumulated that changes in intracellular signaling downstream of desmoglein 3 (Dsg3) may have a significant role in epithelial blistering in the autoimmune disease pemphigus vulgaris (PV).
Anthea Scothern   +29 more
core   +1 more source

iRHOM2 in skin disease and oesophageal cancer [PDF]

open access: yes, 2015
PhDMutations in RHBDF2, the gene encoding inactive rhomboid protein iRHOM2, result in the dominantly inherited condition Tylosis with oesophageal cancer (TOC). TOC causes plamoplantar keratoderma, oral precursor lesions and up to a 95 % life-time risk of
Etheridge, Sarah
core  

Non-pathogenic Anti-Desmoglein 3 IgG Autoantibodies in Fogo Selvagem

open access: yes, 2006
The endemic form of pemphigus foliaceus, fogo selvagem, is caused by IgG autoantibodies directed against desmoglein 1 (Dsg1). Hilario-Vargas and his colleagues describe a high prevalence of IgG autoantibodies against Dsg3, the target antigen of pemphigus
Amagai, Masayuki
core   +1 more source

Stabilization of Keratinocyte Monolayer Integrity in the Presence of Anti-Desmoglein-3 Antibodies through FcRn Blockade with Efgartigimod: Novel Treatment Paradigm for Pemphigus? [PDF]

open access: yesCells, 2022
Zakrzewicz A   +10 more
europepmc   +1 more source

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