Results 61 to 70 of about 18,202,744 (191)

Diagnostic Utility of BIOCHIP Mosaic Indirect Immunofluorescence in Intraepidermal Autoimmune Blistering Diseases

Clinical Dermatology Review
Background: Pemphigus is a chronic intraepidermal autoimmune blistering disorder (IABD) characterized by the presence of circulating autoantibodies against desmogleins 1and 3.
Padmini Chitradurga Vijayasarathy, Rajalakshmi Tirumalae   +1 more
doaj   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

Detection of anti-desmoglein antibodies in oral lichen planus: What do we know so far

Frontiers in Immunology, 2022
Oral lichen planus (OLP) is an inflammatory disease of the oral mucosa. Clinically, two main subsets are described, namely non-erosive and erosive OLP. While non-erosive OLP is usually responsive to local therapies, erosive OLP is often refractory also ...
Dario Didona, Michael Hertl
doaj   +1 more source

Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1

Data in Brief, 2016
This data article contains extended, complementary analysis related to the research articles entitled “Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src” (Tsang et al., 2010) [1] and figures related to the review ...
Hong Wan, Kuang Lin, Siu Man Tsang, Jutamas Uttagomol   +3 more
doaj   +1 more source

Reassessing Remission in Pemphigus Vulgaris: Beyond Complete Remission Towards Meaningful Disease Control

International Journal of Dermatology, EarlyView.
ABSTRACT Current remission criteria for pemphigus vulgaris rely on binary, lesion‐based endpoints that do not capture immunological status, treatment toxicity, or patient quality of life. We argue for a multidimensional framework incorporating minimal disease activity, validated severity scores, glucocorticoid toxicity indices, and patient‐reported ...
Rhea Ahuja, Sumin Hong, Dédée F. Murrell   +2 more
wiley   +1 more source

Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris : correlation with disease severity [PDF]

, 2020
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes caused by autoantibodies against desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). Pemphigus vulgaris (PV) is the most common form of pemphigus. The aim of this study was to assess
Zarghi, Nazila, Layegh, Pouran, Pakfetrat, Atessa, Delavarian, Zarha, Khorashadizadeh, Mahboubeh, Ghazi, Ala   +5 more
core   +1 more source

Incidence of P200 pemphigoid: A nationwide study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The anti‐LAMB4 cell‐based immunoassay is a new serological technique that is far superior to dermal immunoblotting for detecting autoantibodies directed against the P200 protein. This method allows a re‐evaluation of the incidence of P200 pemphigoid, which appears to be considerably more frequent than epidermolysis bullosa acquisita.
Fabienne Jouen, Marion Carrette, Marie‐Laure Golinski, Maud Maho‐Vaillant, Alexis Lefebvre, André Gillibert, Pascal Joly, Vivien Hébert   +7 more
wiley   +1 more source

Proteomic definition of a desmoglein linear determinant common to Pemphigus vulgaris and Pemphigus foliaceous

Journal of Translational Medicine, 2006
Background A number of autoimmune diseases have been clinically and pathologically characterized. In contrast, target antigens have been identified only in a few cases and, in these few cases, the knowledge of the exact epitopic antigenic sequence is ...
Sinha Animesh A, Serpico Rosario, Tessitore Luciana, Mittelman Abraham, Lucchese Alberta, Kanduc Darja   +5 more
doaj   +1 more source

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus

Frontiers in Immunology, 2019
Pemphigus vulgaris (PV) is a life-threatening mucocutaneous autoimmune blistering disease. It is often associated with autoantibodies to the desmosomal adhesion proteins Desmoglein 3 (DSG3) and Desmoglein 1 (DSG1).
Roberta Lotti, Claudio Giacinto Atene, Alessandra Marconi, Giulia Di Rocco, L. Reggiani Bonetti, Tommaso Zanocco Marani, Carlo Pincelli   +6 more
doaj   +1 more source