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Structural studies on desmosomes
Biochemical Society Transactions, 2008Desmosomes are cadherin-based intercellular junctions that primarily provide mechanical stability to tissues such as epithelia and cardiac muscle. Desmosomal cadherins, which are Ca2+-dependent adhesion molecules, are of central importance in mediating direct intercellular interaction.
Ashraf, Al-Amoudi +1 more
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Inherited desmosomal disorders
Cell and Tissue Research, 2014Desmosomes serve as intercellular junctions in various tissues including the skin and the heart where they play a crucial role in cell-cell adhesion, signalling and differentiation. The desmosomes connect the cell surface to the keratin cytoskeleton and are composed of a transmembranal part consisting mainly of desmosomal cadherins, armadillo proteins ...
Liat, Samuelov, Eli, Sprecher
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Cell Communication & Adhesion, 2014
Desmosomes are intercellular junctions that provide strong adhesion or hyper-adhesion in tissues. Here, we discuss the molecular and structural basis of this with particular reference to the desmosomal cadherins (DCs), their isoforms and evolution. We also assess the role of DCs as regulators of epithelial differentiation.
Mohamed, Berika, David, Garrod
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Desmosomes are intercellular junctions that provide strong adhesion or hyper-adhesion in tissues. Here, we discuss the molecular and structural basis of this with particular reference to the desmosomal cadherins (DCs), their isoforms and evolution. We also assess the role of DCs as regulators of epithelial differentiation.
Mohamed, Berika, David, Garrod
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Hereditary diseases of desmosomes
Journal of Dermatological Science, 1999Desmosomes are key adhesion complexes in most epithelia, including epidermis. Although structural components of desmosomes have been identified as target antigens in several of the autoimmune blistering skin diseases, there are relatively few data on inherited disorders arising from mutations in genes encoding these proteins and glycoproteins.
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Structure and Function of Desmosomes
2007Desmosomes are prominent adhesion sites that are tightly associated with the cytoplasmic intermediate filament cytoskeleton providing mechanical stability in epithelia and also in several nonepithelial tissues such as cardiac muscle and meninges. They are unique in terms of ultrastructural appearance and molecular composition with cell type-specific ...
Bastian, Holthöfer +3 more
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Inherited disorders of desmosomes
Australasian Journal of Dermatology, 2005SUMMARYDesmosomes are highly organized intercellular junctions that provide mechanical integrity to tissues by anchoring intermediate filaments to sites of strong adhesion. These cell–cell adhesion junctions are found in skin, heart, lymph nodes and meninges.
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Annual Review of Pathology: Mechanisms of Disease, 2018
Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly
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Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders. The desmosome is an essential cell-cell junctional protein complex in tissues that undergo stress, and it orchestrates intracellular signal transduction. Desmosome assembly
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Desmosomes and their autoimmune pathologies.
European journal of dermatology : EJD, 2000Desmosomes guarantee the integrity of the epidermis, by functioning both as an adhesive complex and as a cell-surface attachment site for the keratin intermediate filaments of the cytoskeleton. Considerable progress has been made in our knowledge of desmosomes and their components.
COZZANI, EMANUELE CLAUDIO +4 more
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miR-195-5p as Regulator of γ-Catenin and Desmosome Junctions in Colorectal Cancer
International Journal of Molecular Sciences, 2023Viviana Scalavino +2 more
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