Results 1 to 10 of about 12,732 (174)
A transitional desmosome/tonofibril network may relay mechanical strain to epidermal nerve terminals with high fidelity and sensitivity in the Cuban crocodile (Crocodylus rhombifer): an ultrastructural study [PDF]
Frontiers in Cell and Developmental BiologyBackgroundCrocodilians are well endowed with multiple cutaneous receptors and specializations, such as integumentary sensory organs (ISOs), which provide formidable mechanical sensitivity despite their protected shield.
Karl-Gunnar Melkersson +5 more
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The impact of signaling pathways on the desmosome ultrastructure in pemphigus [PDF]
Frontiers in ImmunologyIntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells.
Thomas Schmitt +5 more
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Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
Nature Communications, 2018 Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J Price +2 more
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Actomyosin forces trigger a conformational change in desmoplakin within desmosomes [PDF]
Nature CommunicationsDesmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Yinchen Dong +6 more
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Desmin-p.L112Q Disturbs Filament Formation and Is a Likely-Pathogenic Variant Associated with Dilated Cardiomyopathy [PDF]
Journal of Cardiovascular Development and DiseaseDES encodes the muscle-specific intermediate filament protein desmin, which is highly relevant to the structural integrity of cardiomyocytes. Mutations in this gene cause different cardiomyopathies including dilated cardiomyopathy.
Alexander Lütkemeyer +7 more
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Frontiers in Immunology, 2022 Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt +7 more
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Российский кардиологический журнал, 2021 Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary myocardial disease with a high risk of sudden cardiac death. The most common genetic forms of the disease are associated with desmosomal gene mutations.Aim. To study the prevalence of
A. G. Shestak +4 more
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Cells, 2023 The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 ...
Hong Wan +3 more
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Vaccines, 2022 Pemphigus vulgaris (PV) is a chronic, life-altering autoimmune disease due to the production of anti-desmoglein antibodies causing the loss of cell–cell adhesion in keratinocytes (acantholysis) and blister formation in both skin and mucous membranes. The
Morna F. Schmidt +4 more
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Frontiers in Pharmacology, 2022 According to the World Health Organization, the neoplasm is one of the main reasons for morbidity and mortality worldwide. At the same time, application of cytostatic drugs like an independent type of cancer treatment and in combination with surgical ...
Ekaterina Podyacheva, Yana Toropova
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