Results 1 to 10 of about 20,510 (243)
Dermatology Research and Practice, 2010 The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium-independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength.
David Garrod
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Journal of Cell Science, 2009 Desmosomes are one of four intercellular junctions present on the lateral side of neighboring polarized epithelial cells. Tight junctions and adherens junctions (AJs) are restricted to the apical domain, where they form the epithelial barrier and ...
Bhushan V. Desai +2 more
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Frontiers in Immunology, 2022 Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt +7 more
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Desmosomes as Signaling Hubs in the Regulation of Cell Behavior
Frontiers in Cell and Developmental Biology, 2021 Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to ...
Lisa Müller +2 more
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Mechanical loading of desmosomes depends on the magnitude and orientation of external stress
Nature Communications, 2018 Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J. Price +5 more
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Structure and regulation of desmosomes in intercalated discs: Lessons from epithelia [PDF]
Journal of Anatomy, 2022 For electromechanical coupling of cardiomyocytes, intercalated discs (ICDs) are pivotal as highly specialized intercellular contact areas. ICD consists of adhesive contacts, such as desmosomes and adherens junctions (AJs) that are partially intermingled ...
Sunil Yeruva, Jens Waschke
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Desmosomes undergo dynamic architectural changes during assembly and maturation [PDF]
Tissue Barriers, 2022 Desmosomes are macromolecular cell-cell junctions critical for maintaining adhesion and resisting mechanical stress in epithelial tissue. Desmosome assembly and the relationship between maturity and molecular architecture are not well understood.
Reena R. Beggs +4 more
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PLoS ONE, 2014 Desmosomes are intercellular adhesive junctions of major importance for tissue integrity. To allow cell motility and migration they are down-regulated in epidermal wound healing.
Selina McHarg +3 more
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F1000Research, 2019 The development of adhesive connections between cells was critical for the evolution of multicellularity and for organizing cells into complex organs with discrete compartments. Four types of intercellular junction are present in vertebrates: desmosomes,
Kathleen J Green +2 more
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150th anniversary series: Desmosomes in physiology and disease [PDF]
Cell Communication & Adhesion, 2014 Nicola Cirillo
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