Results 1 to 10 of about 13,508 (185)

The impact of signaling pathways on the desmosome ultrastructure in pemphigus. [PDF]

Front Immunol
IntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells.
Schmitt T, Huber J, Pircher J, Schmidt E, Waschke J.   +4 more
europepmc   +2 more sources

Mechanical loading of desmosomes depends on the magnitude and orientation of external stress

Nature Communications, 2018
Desmosomes are intercellular adhesion complexes that connect the intermediate filament cytoskeletons of neighboring cells but direct evidence for their load-bearing nature is lacking.
Andrew J Price, Anna-Lena Cost, Jens Waschke   +2 more
exaly   +2 more sources

Actomyosin forces trigger a conformational change in desmoplakin within desmosomes. [PDF]

Nat Commun
Desmosomes are essential cell-cell adhesion organelles that enable tension-prone tissues, like the skin and heart, to withstand mechanical stress.
Dong Y, Elgerbi A, Xie B, Han Y, Kwiatkowski AV, Choy JS, Sivasankar S.   +6 more
europepmc   +2 more sources

E-cadherin binds to desmoglein to facilitate desmosome assembly

eLife, 2018
Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both trans (between opposing cells) and cis (on the
Omer Shafraz, Matthias Rübsam, Sara N Stahley, Amber L Caldara, Andrew P Kowalczyk, Carien M Niessen, Sanjeevi Sivasankar   +6 more
doaj   +2 more sources

Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases. [PDF]

J Cell Sci
Waschke J, Amagai M, Becker C, Delmar M, Duru F, Garrod DR, Gerull B, Green KJ, Hertl M, Kowalczyk AP, Niessen CM, Nusrat A, Schinner C, Schlegel N, Sivasankar S, Vielmuth F, Spindler V.   +16 more
europepmc   +2 more sources

The desmosome comes into focus. [PDF]

J Cell Biol
Bharathan NK, Mattheyses AL, Kowalczyk AP.   +2 more
europepmc   +2 more sources

Dsg1 and Dsg3 Composition of Desmosomes Across Human Epidermis and Alterations in Pemphigus Vulgaris Patient Skin

Frontiers in Immunology, 2022
Desmosomes are important epidermal adhesion units and signalling hubs, which play an important role in pemphigus pathogenesis. Different expression patterns of the pemphigus autoantigens desmoglein (Dsg)1 and Dsg3 across different epidermal layers have ...
Thomas Schmitt, Julia Pircher, Letyfee Steinert, Katharina Meier, Kamran Ghoreschi, Franziska Vielmuth, Daniela Kugelmann, Jens Waschke   +7 more
doaj   +1 more source

Spectrum of desmosomal gene variations in patients with arrhythmogenic right ventricular cardiomyopathy

Российский кардиологический журнал, 2021
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary myocardial disease with a high risk of sudden cardiac death. The most common genetic forms of the disease are associated with desmosomal gene mutations.Aim. To study the prevalence of
A. G. Shestak, O. V. Blagova, Yu. A. Lutokhina, S. L. Dzemeshkevich, E. V. Zaklyazminskaya   +4 more
doaj   +1 more source

Cyclodextrin Counteracts Coxsackievirus-Induced Cardiac Damage by Protecting Desmosome Integrity and Suppressing Proinflammatory Cytokine Expression. [PDF]

Microorganisms
Zhao G, Zhang HM, Zhang GJ, Yang W, Küper C, McManus BM, Yang D.   +6 more
europepmc   +3 more sources

Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells

Cells, 2023
The role of desmoglein-3 (DSG3) in oncogenesis is unclear. This study aimed to uncover molecular mechanisms through comparative transcriptome analysis in oral cancer cells, defining potential key genes and associated biological processes related to DSG3 ...
Hong Wan, Muy-Teck Teh, Giulia Mastroianni, Usama Sharif Ahmad   +3 more
doaj   +1 more source