Results 11 to 20 of about 20,510 (243)
The role of desmosomes in carcinogenesis
OncoTargets and Therapy, 2017 Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments.
Guangxi Zhou +6 more
semanticscholar +6 more sources
The impact of signaling pathways on the desmosome ultrastructure in pemphigus [PDF]
Frontiers in ImmunologyIntroductionThe autoantibody-driven disease pemphigus vulgaris (PV) impairs desmosome adhesion in the epidermis. In desmosomes, the pemphigus autoantigens desmoglein 1 (Dsg1) and Dsg3 link adjacent cells.
Thomas Schmitt +5 more
doaj +2 more sources
New insights into desmosome regulation and pemphigus blistering as a desmosome-remodeling disease
Kaohsiung Journal of Medical Sciences, 2013 Desmosomes in keratinocytes are the most important intercellular adhering junctions that provide structural strength for the epidermis. These junctions are connected directly with desmosomal cadherin proteins.
Yasuo Kitajima
doaj +3 more sources
The desmosome comes into focus. [PDF]
J Cell BiolThe desmosome is a cell–cell adhesive junction that provides integrity and mechanical resistance to tissues through its attachment to the intermediate filament cytoskeleton. Defects in desmosomes cause diseases impacting the heart, epidermis, and other epithelia.
Bharathan NK +2 more
europepmc +3 more sources
Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes [PDF]
Journal of Cell Biology, 2011 Desmogleins and desmocollins are transported to the plasma membrane by different kinesin motors, providing a potential mechanism to tailor desmosome structure and function during development and epithelial remodeling.
O. Nekrasova +5 more
semanticscholar +6 more sources
Annual Review of Pathology: Mechanisms of Disease, 2018 Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities that affect sites of cell-cell contact can cause a variety of debilitating disorders.
N. A. Najor
semanticscholar +4 more sources
ISOLATION OF EPIDERMAL DESMOSOMES [PDF]
The Journal of Cell Biology, 1974 A method is reported for the isolation of desmosomes in a high yield and of a purity suitable for biochemical analysis. The procedure utilizes the selective solubilizing action of citric acid-sodium citrate (CASC) buffer, pH 2.6, on the non-cornified layers of cow nose epidermis, followed by discontinuous sucrose density gradient centrifugation ...
Christine J. Skerrow, A. Gedeon Matoltsy
openalex +4 more sources
Dsg2 ectodomain organization increases throughout desmosome assembly [PDF]
Cell Adhesion & MigrationDesmosomes are intercellular junctions that regulate mechanical integrity in epithelia and cardiac muscle. Dynamic desmosome remodeling is essential for wound healing and development, yet the mechanisms governing junction assembly remain elusive.
William F. Dean +5 more
doaj +2 more sources
Desmosomes in acquired disease [PDF]
Cell and Tissue Research, 2015 Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement integrates adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, which ...
S. Stahley, A. Kowalczyk
semanticscholar +4 more sources
Desmosome assembly, homeostasis, and desmosomal disease
Cell Health and Cytoskeleton, 2016 Nicola Cirillo1,2 1Melbourne Dental School and Oral Health CRC, The University of Melbourne, Melbourne, VIC, Australia; 2Research Unit, Centre for Innovation, Research, Education, and Health (IRIS), Caposele, Italy Abstract: Cell–cell adhesion is involved in all aspects of tissue behavior in multicellular organisms, from tissue morphogenesis
Nicola Cirillo
openalex +5 more sources