Results 11 to 20 of about 10,823 (192)
Deubiquitinating Enzymes and Bone Remodeling [PDF]
Stem Cells International, 2018 Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling ...
Yu-chen Guo, Shi-wen Zhang, Quan Yuan
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A Method for Assaying Deubiquitinating Enzymes [PDF]
Biological Procedures Online, 1998 A general method for the assay of deubiquitinating enzymes was described in detail using 125I-labeled ubiquitin-fused &agr;NH-MHISPPEPESEEEEEHYC (referred to as Ub-PESTc) as a substrate.
Lee Jae Il +6 more
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Targeting deubiquitinating enzymes in cancer stem cells [PDF]
Cancer Cell International, 2017 Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential for CSC maintenance and differentiation ...
Hu Lei, Huizhuang Shan, Yingli Wu
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Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans. [PDF]
PLoS ONE, 2012 Ubiquitination is a reversible protein modification that influences various cellular processes in eukaryotic cells. Deubiquitinating enzymes remove ubiquitin, maintain ubiquitin homeostasis and regulate protein degradation via the ubiquitination pathway.
Wei Fang +8 more
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Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation. [PDF]
PLoS ONE, 2015 Although protein ubiquitination has been shown to regulate multiple processes during host response to Salmonella enterica serovar Typhimurium infection, specific functions of host deubiquitinating enzymes remain unknown in this bacterial infection.
Evangel Kummari +5 more
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Advances in deubiquitinating enzymes in lung adenocarcinoma. [PDF]
J Cancer, 2021 The process of ubiquitination and deubiquitination is widely present in the human body's protein reactions and plays versatile roles in multiple diseases. Deubiquitinating enzymes (DUBs) are significant regulators of this process, which cleave the ubiquitin (Ub) moiety from various substrates and maintain protein stability.
Zhou XJ, Li R, Liu X, Qu YQ.
europepmc +4 more sources
Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
Frontiers in Chemistry, 2020 The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making its tight regulation key to ...
Neil C. Taylor, Joanna F. McGouran
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Protein partners of deubiquitinating enzymes [PDF]
Biochemical Journal, 2008 Protein modification by ubiquitin and ubiquitin-like molecules is a critical regulatory process. Like most regulated protein modifications, ubiquitination is reversible. Deubiquitination, the reversal of ubiquitination, is quickly being recognized as an important regulatory strategy.
Karen H, Ventii, Keith D, Wilkinson
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Deubiquitinating enzymes as oncotargets
Oncotarget, 2015 Carcinogenesis is a complex process tightly regulated at multiple levels by post-translational modifications. Epigenetics plays a major role in cancer development, all stable changes to the gene expression process that are not a result of a direct change in the DNA code are described as epigenetics.
McClurg UL, Robson CN
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Deubiquitinating enzymes at the crossroads of lipid metabolism and cancer
Journal of Biological Research - Thessaloniki, 2021 Deregulated lipid metabolism has been recognized as a critical alteration that supports the development and growth of various types of tumors. Changes in lipid metabolism enable reprogramming of energetics and availability of synthetic intermediates and ...
Christos Gonidas +2 more
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