Results 31 to 40 of about 10,823 (192)
Emerging Roles of Ubiquitin-Specific Protease 25 in Diseases
Frontiers in Cell and Developmental Biology, 2021 The balance of ubiquitination and deubiquitination plays diverse roles in regulating protein stability and cellular homeostasis. Deubiquitinating enzymes catalyze the hydrolysis and removal of ubiquitin chains from target proteins and play critical roles
Wenjing Zhu +6 more
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A family of unconventional deubiquitinases with modular chain specificity determinants
Nature Communications, 2018 Deubiquitinating enzymes (DUBs) are essential to modulate ubiquitin signaling. While known DUBs can be grouped into six families, the authors here present biochemical and structural evidence for a seventh DUB family, defining determinants of substrate ...
Thomas Hermanns +7 more
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Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities?
Cells, 2018 Autophagy is an evolutionary conserved catabolic process that allows for the degradation of intracellular components by lysosomes. This process can be triggered by nutrient deprivation, microbial infections or other challenges to promote cell survival ...
Anne-Claire Jacomin +2 more
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Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
PLoS ONE, 2011 Deubiquitinating enzymes (DUBs) are important regulators of cell proliferation. Here we identified a functional deubiquitinating enzyme, ovarian tumor domain-containing 6B (OTUD-6B).
Zhongping Xu +4 more
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Meddling with Fate: The Proteasomal Deubiquitinating Enzymes [PDF]
Journal of Molecular Biology, 2017 Three deubiquitinating enzymes-Rpn11, Usp14, and Uch37-are associated with the proteasome regulatory particle. These enzymes allow proteasomes to remove ubiquitin from substrates before they are translocated into the core particle to be degraded. Although the translocation channel is too narrow for folded proteins, the force of translocation unfolds ...
Stefanie A H, de Poot +2 more
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Viral deubiquitinating proteases and the promising strategies of their inhibition
Virus ResearchSeveral viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling ...
Vera J.E. van Vliet +3 more
doaj +1 more source
Nature Communications, 2022 The biological roles of deubiquitinating enzymes (DUBs) in pancreatic ductal adenocarcinoma (PDAC) are not fully explored. Here the authors perform activity based proteomics with a loss of function genetic screen and identify that USP25 promotes PDAC ...
Jessica K. Nelson +18 more
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Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease
Cells, 2015 Autophagy is an evolutionarily-conserved process that delivers diverse cytoplasmic components to the lysosomal compartment for either recycling or degradation.
Fouzi El Magraoui +3 more
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Advanced Science, EarlyView.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source
Mechanism and function of deubiquitinating enzymes
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2004 Attachment of ubiquitin to proteins is a crucial step in many cellular regulatory mechanisms and contributes to numerous biological processes, including embryonic development, the cell cycle, growth control, and prevention of neurodegeneration. In these diverse regulatory settings, the most widespread mechanism of ubiquitin action is probably in the ...
Amerik, Alexander Y., Hochstrasser, Mark
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