Dextromethorphan-bupropion combination in depression with dual diagnosis: Insights from a case series [PDF]
Indian Journal of PsychiatryBackground: Major depressive disorder and co-morbid substance use disorder represent a challenging dual diagnosis, characterized by persistent anhedonia, high relapse rates, and poor response to conventional antidepressants.
Mahak Aggarwal +4 more
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Dextromethorphan Bupropion Combination Tablet Suicide Attempt by Overdose: A Case Report [PDF]
Neuropsychopharmacology ReportsDextromethorphan and bupropion in combination are approved to treat major depressive disorders in adults. This case report describes a patient with a history of treatment‐resistant depression who presented to the emergency department after overdosing on ...
Daniel Greer +3 more
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Awareness and practices of community pharmacists toward dextromethorphan misuse in Jeddah, Saudi Arabia: implications for regulation and public health [PDF]
Frontiers in MedicineBackgroundDextromethorphan (DXM) is an over-the-counter cough suppressant with recognized potential for misuse and abuse when taken at supratherapeutic doses. Community pharmacists are well positioned to identify and prevent such misuse, yet limited data
Aisha T. Alnami +7 more
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Deuteration may reduce the efficacy of dextromethorphan in treating agitation in Alzheimer’s disease [PDF]
Alzheimer’s Research & TherapyAgitation is one of the most prevalent neuropsychiatric symptoms leading to institutionalization in individuals with Alzheimer’s disease (AD) dementia.
Anton Bespalov +3 more
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Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat [PDF]
Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021 Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine.
Rasol Sadeghy +2 more
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Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
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Bilateral nephrolithiasis following ingestion of guaifenesin and dextromethorphan
Urology Case Reports, 2023 Both guaifenesin and dextromethorphan are routinely available nonprescription medications that are also common drugs of abuse amongst young adults. We describe a presentation of guaifenesin and dextromethorphan misuse resulting in acute renal failure due
Elizabeth Kim +3 more
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Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
PLoS ONE, 2014 Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine.
Linda Nguyen +4 more
doaj +1 more source
UNDULY ENHANCED RESPONSE TO TOLVAPTAN IN A WOMAN SHOWING SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION: AN INVESTIGATION OF POSSIBLE CAUSES [PDF]
, 2017 Objective: To investigate possible causes of an excessive response to tolvaptan in a woman with syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Lanzellotti, Davide +4 more
core +1 more source
Deaths due to abuse of dextromethorphan sold over-the-counter in Pakistan
Egyptian Journal of Forensic Sciences, 2016 Dextromethorphan is the most commonly used over-the-counter anti-tussive and expectorant medicine at therapeutic doses. Due to easy availability, euphoric high and hallucinogenic effects at larger doses, dextromethorphan popularity amongst the drug ...
Humera Shafi +7 more
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