Demographic characteristics and psychosocial backgrounds of patients with dextromethorphan overdose in Japan: A multicenter prospective observational study [PDF]
PCN ReportsAim Few studies in Japan have described young patients presenting to emergency departments after dextromethorphan overdose in detail. Therefore, we aimed to investigate the demographic characteristics and psychosocial backgrounds of patients who ...
Hironori Katsuki +10 more
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Journal of Pharmacological Sciences, 2008 Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects ...
Eun-Joo Shin +4 more
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Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan. [PDF]
PLoS ONE, 2014 Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine.
Linda Nguyen +4 more
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Deaths due to abuse of dextromethorphan sold over-the-counter in Pakistan
Egyptian Journal of Forensic Sciences, 2016 Dextromethorphan is the most commonly used over-the-counter anti-tussive and expectorant medicine at therapeutic doses. Due to easy availability, euphoric high and hallucinogenic effects at larger doses, dextromethorphan popularity amongst the drug ...
Humera Shafi +7 more
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Dextromethorphan-bupropion combination in depression with dual diagnosis: Insights from a case series [PDF]
Indian Journal of PsychiatryBackground: Major depressive disorder and co-morbid substance use disorder represent a challenging dual diagnosis, characterized by persistent anhedonia, high relapse rates, and poor response to conventional antidepressants.
Mahak Aggarwal +4 more
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A Staged Translational Framework for Evaluating Oral Glutamatergic and Senescence-Modulating Strategies in Treatment-Resistant Depression [PDF]
Drug Design, Development and TherapyNgo CheungCheung Ngo Medical Limited, Hong Kong SAR, People’s Republic of ChinaCorrespondence: Ngo Cheung, Cheung Ngo Medical Limited, Hong Kong SAR, People’s Republic of China, Tel +852 9876 8323, Email info@cheungngomedical.comAbstract: Treatment ...
Cheung N
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A review of dextromethorphan and bupropion (Auvelity™) for the treatment of agitation in Alzheimer’s disease [PDF]
Drugs in ContextDextromethorphan hydrobromide and bupropion hydrochloride extended-release tablets (AuvelityTM) became the second medication to be approved by the FDA for the treatment of agitation in Alzheimer’s disease dementia after brexpiprazole.
Rajesh R Tampi +4 more
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Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat [PDF]
Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021 Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine.
Rasol Sadeghy +2 more
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The Dextromethorphan Defense: Dextromethorphan and the Opioid Screen [PDF]
Academic Emergency Medicine, 1995 ABSTRACTObjective: To determine whether a single oral dose of dextromethorphan produces a falsely positive qualitative urine opioid screen.Methods:A prospective, randomized, triple‐blind, placebo‐controlled, crossover exposure study design was used. Twenty adult volunteers participated.
A B, Storrow, M R, Magoon, J, Norton
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Bilateral nephrolithiasis following ingestion of guaifenesin and dextromethorphan
Urology Case Reports, 2023 Both guaifenesin and dextromethorphan are routinely available nonprescription medications that are also common drugs of abuse amongst young adults. We describe a presentation of guaifenesin and dextromethorphan misuse resulting in acute renal failure due
Elizabeth Kim +3 more
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