Results 1 to 10 of about 423 (118)
Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs
Journal of Pharmacological Sciences, 2011 .: Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its ...
Jau-Shyong Hong +2 more
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Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat [PDF]
Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021 Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine.
Rasol Sadeghy +2 more
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The Dextromethorphan Defense: Dextromethorphan and the Opioid Screen [PDF]
Academic Emergency Medicine, 1995 ABSTRACTObjective: To determine whether a single oral dose of dextromethorphan produces a falsely positive qualitative urine opioid screen.Methods:A prospective, randomized, triple‐blind, placebo‐controlled, crossover exposure study design was used. Twenty adult volunteers participated.
A B, Storrow, M R, Magoon, J, Norton
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Bilateral nephrolithiasis following ingestion of guaifenesin and dextromethorphan
Urology Case Reports, 2023 Both guaifenesin and dextromethorphan are routinely available nonprescription medications that are also common drugs of abuse amongst young adults. We describe a presentation of guaifenesin and dextromethorphan misuse resulting in acute renal failure due
Elizabeth Kim +3 more
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Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.
PLoS ONE, 2014 Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine.
Linda Nguyen +4 more
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Deaths due to abuse of dextromethorphan sold over-the-counter in Pakistan
Egyptian Journal of Forensic Sciences, 2016 Dextromethorphan is the most commonly used over-the-counter anti-tussive and expectorant medicine at therapeutic doses. Due to easy availability, euphoric high and hallucinogenic effects at larger doses, dextromethorphan popularity amongst the drug ...
Humera Shafi +7 more
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Journal of Pharmacological Sciences, 2008 Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects ...
Eun-Joo Shin +4 more
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Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction. [PDF]
PLoS ONE, 2014 Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved
Jasbir D Upadhyaya +7 more
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Journal of Anaesthesiology Clinical Pharmacology, 2011 Background : Fentanyl-induced cough is not always benign and brief and can be remarkably troublesome, spasmodic, and explosive. Dextromethorphan, an opioid derivative with an antitussive action, may be effective in reducing the fentanyl-induced cough ...
Avik Mukherjee +5 more
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Pediatria i Medycyna Rodzinna, 2019 Aim: The aim of the study was to retrospectively assess cases of intentional dextromethorphan intoxication which were the reason for admissions to the Department of Paediatrics and Gastroenterology at the Medical University of Lublin between 2008 and ...
Karol Krawiec +1 more
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