Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring [PDF]
, 2011 [[abstract]]Background: Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring.
Pao-Luh Tao +2 more
core +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2017 (9S,13S,14S)-3-Methoxy-17-methylmorphinan (dextromethorphan) forms two isostructural salts with (a) tetrachloridocobaltate, namely bis[(9S,13S,14S)-3-methoxy-17-methylmorphinanium] tetrachloridocobaltate, (C18H26NO)2[CoCl4], and (b) tetrachloridocuprate,
Eric Gauchat, Alexander Y. Nazarenko
doaj +1 more source
Effect of a single dose of dextromethorphan on psychomotor performance and working memory capacity
Indian Journal of Psychological Medicine, 2012 Background: Previous studies show that the prolonged use of dextromethorphan produces cognitive deterioration in humans. Aim: The aim of this study was to investigate the effect of a single dose of dextroemthrophan on psychomotor performance and working ...
Hayder M Al-Kuraishy +2 more
doaj +1 more source
PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury [PDF]
, 2016 BACKGROUND: Phase 3 trials supporting dextromethorphan/quinidine (DM/Q) use as a treatment for pseudobulbar affect (PBA) were conducted in patients with amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS).
Alexander, David N. +12 more
core +4 more sources
Comparison of the Effects of Preemptive Gabapentin and Dextromethorphan on the Postoperative Pain after Open Prostatectomy [PDF]
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2009 Background and Objectives: Preemptive administration of gabapentin and dextromethorphan has been shown to be effective for reduction of postoperative pain; but the effect of these two drugs has not yet been compared.
M.R. Mohaghegh, B. Kavand
doaj +2 more sources
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie International Edition, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +1 more source
Antitussive Activity of Herbal Cough Medicine on Guinea Pigs (Cavia porvellus)
Majalah Obat Tradisional, 2021 This study aims to investigate the antitussive activity of herbal cough medicine containing combined herbal extracts of Echinacea purpurea, Sambucus nigra (Black Elderberry), Glycyrrhiza glabra (licorice), Vitex trifolia (Indian wild pepper), and ...
Zullies Ikawati +4 more
doaj +1 more source
Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review
Clinical Pharmacology &Therapeutics, EarlyView.Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović +4 more
wiley +1 more source
Frontiers in Immunology, 2019 The high genetic variability of influenza A viruses poses a continual challenge to seasonal and pandemic vaccine development, leaving antiviral drugs as the first line of defense against antigenically different strains or new subtypes.
Theresa Enkirch +9 more
doaj +1 more source
THE ROLE OF DEXTROMETHORPHAN IN EIGHT FATAL OVERDOSES: IS IT SOLELY A CUTTING SUBSTANCE FOR HEROIN OR COULD IT BE SOMETHING MORE? [PDF]
Euromediterranean Biomedical Journal, 2015 The Authors evaluate the role of dextromethorphan as heroin adulterant. From December 2010 through April 2013, in our Laboratory of Forensic Toxicology of University of Catania, eight fatal overdose of heroin cut with dextromethorphan were observed ...
Francesca Indorato
doaj +1 more source