新しい方法を用いた,モルモットの咳に対する中枢性鎮咳薬の効果の検討 [PDF]
The present study was conducted to evaluate the effects of dextromethorphan and codeine on the elements of the coughing motion under the condition of upper respiratory inflammation.
坂本 芳雄, 河本 定則, 田中 求
core
Contra-thermodynamic hydrogen atom abstraction in the selective C−H functionalization of trialkylamine N‑CH3 groups [PDF]
We report a simple one-pot protocol that affords functionalization of N-CH3 groups in N-methyl-N,N-dialkylamines with high selectivity over N-CH2R or N-CHR2 groups.
Barham, Joshua P. +2 more
core +1 more source
Background and Objective: Dextromethorphan is a well-known over-the-counter antitussive drug with over 45 years of clinical usage experience.
D Farzin, M Zavareh
doaj
Have Halpern et al. (2004) detected 'residual neuropsychological effects' of MDMA? Not likely [PDF]
[Extract] The preliminary study by Halpern et al. (2004) is a commendable attempt to isolate correlates of ‘Ecstasy’ use from some of the many confounds that have plagued previous work on this controversial issue. However, Halpern et al.
Hasking, Penelope, Lyvers, Michael
core +1 more source
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Pharmacokinetics in morbid obesity: influence of two bariatric surgery techniques on paracetamol and caffeine metabolism [PDF]
The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). In the present prospective study, we
Civit, Ester +9 more
core +2 more sources
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe +20 more
core +2 more sources
Addiction‐related problems in Japan: A regional perspective
Abstract Japan's addiction landscape appears paradoxical. The lifetime use of illicit drugs is among the lowest in Organisation for Economic Cooperation and Development countries, but harm from alcohol, tobacco, and gambling ranks among the world's highest.
Soichiro Ide +19 more
wiley +1 more source
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore
Yue He +6 more
doaj +1 more source
Evaluation of an in-capillary approach for performing quantitative cytochrome P450 activity studies [PDF]
An automated in-capillary assay requiring very small quantities of reagents was developed for performing in vitro cytochrome P450 (CYP450) drug metabolism studies. The approach is based on the following: (i) hydrodynamic introduction of nanoliter volumes
Curcio, R. +3 more
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