Results 51 to 60 of about 9,214 (193)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Speech, language, social communication, and communication assessments in Rett syndrome: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
This systematic overview highlights communication impairment as a defining feature of Rett syndrome, with expressive language consistently affected more severely than receptive language and social ability. Across the literature, most studies rely on caregiver‐reported measures, with relatively few employing direct or objective measurements of speech ...
Lucas N. Raniolo, Ruth O. Braden, Jana von Hehn, John Christodoulou, David N. Lieberman, David J. Amor, Adam P. Vogel   +6 more
wiley   +1 more source

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End‐of‐Life Palliative Care

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Daiping Li, Yanwu Yang, Yan Zhang, Jirong Yue, Birong Dong, Meiling Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +7 more
wiley   +1 more source

Myoclonus After Dextromethorphan Administration in Peritoneal Dialysis

, 2010
Objective To report a case of myoclonus that developed after administration of dextromethorphan. Case Summary: A 64-year-old man was diagnosed with chronic renal failure due to diabetic nephropathy.
Atsushi Nomura, Hideaki Shimizu, Makoto Yamaguchi, Akio Tanaka, Tatsuhito Watanabe, Fumiko Nagura, Kayaho Maeda, Yoshiro Fujita, Tatsuhito Tornino, Yasuhiko Ito, Tadashi Nagamatsu   +10 more
core   +1 more source

c-Jun N-terminal kinase 3 expression in the retina of ocular hypertension mice: a possible target to reduce ganglion cell apoptosis

Neural Regeneration Research, 2015
Glaucoma, a type of optic neuropathy, is characterized by the loss of retinal ganglion cells. It remains controversial whether c-Jun N-terminal kinase (JNK) participates in the apoptosis of retinal ganglion cells in glaucoma. This study sought to explore
Yue He, Jie Chen, Shu-guang Zhang, Yuan-sheng Yuan, Yan Li, Hong-bin Lv, Jin-hua Gan   +6 more
doaj   +1 more source

Competitive antagonism of the behavioral effects of dextromethorphan by BD1063.

, 2014
A single dose of BD1063 (10 mg/kg, i.p.) pretreatment shifted the dextromethorphan (0–50 mg/kg, i.p.) dose response curve to the right in the forced swim test (A), and blocked the dextromethorphan-induced stimulatory effect in the locomotor study (B ...
Anna L. Scandinaro (529242), Jason R. Healy (529241), Linda Nguyen (195959), Rae R. Matsumoto (529243), Matthew J. Robson (529240)   +4 more
core   +1 more source

Visual bone marrow mesenchymal stem cell transplantation in the repair of spinal cord injury

Neural Regeneration Research, 2015
An important factor in improving functional recovery from spinal cord injury using stem cells is maximizing the number of transplanted cells at the lesion site.
Rui-ping Zhang, Cheng Xu, Yin Liu, Jian-ding Li, Jun Xie   +4 more
doaj   +1 more source

N‐methyl‐D‐aspartate receptor antagonists for controlling pain in dogs

Journal of Small Animal Practice, EarlyView.
This is a mini review published by the World Small Animal Veterinary Association's Pain Committee. This article provides an assessment of the scientific evidence of N‐methyl‐d‐aspartate receptor antagonists for controlling pain in dogs while identifying current knowledge gaps.
P. W. Kronen, B. D. X. Lascelles, B. P. Monteiro, J. C. Murrell, S. A. Robertson, P. V. Steagall, B. Wright   +6 more
wiley   +1 more source

What drives progressive motor deficits in patients with acute pontine infarction?

Neural Regeneration Research, 2015
Progressive motor deficits are relatively common in acute pontine infarction and frequently associated with increased functional disability. However, the factors that affect the progression of clinical motor weakness are largely unknown. Previous studies
Jue-bao Li, Rui-dong Cheng, Liang Zhou, Wan-shun Wen, Gen-ying Zhu, Liang Tian, Xiang-ming Ye   +6 more
doaj   +1 more source

Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
What could be done with pharmaceutical waste from a circular chemistry perspective? A literature survey was conducted using the terms “recycling”, “upcycling”, “reuse”, “repurposing”, “pharmaceutical”, “expired drug”, “expired medicine”, “unused drug” and “unused medicine” in the databases Scopus, Web of Science and Periódicos CAPES to answer this ...
Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão   +3 more
wiley   +1 more source