Results 71 to 80 of about 13,931 (178)
Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
MedComm, Volume 7, Issue 4, April 2026.Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai +3 more
wiley +1 more source
INVOLUNTARY EMOTIONAL EXPRESSION DISORDER IN ALZHEIMER\u27S DISEASE - PSYCHOPHARMACOTHERAPY ASPECTS [PDF]
, 2009 Involuntary emotional expression disorder (IEED) is syndrome characterized with relatively stereotypical episodes of uncontrollable crying and/or laughing. Additionally, this syndrome can include irritability, anger and frustration.
Ninoslav Mimica +2 more
core +1 more source
Do activities of cytochrome P450 (CYP)3A, CYP2D6 and P-glycoprotein differ between healthy volunteers and HIV-infected patients? [PDF]
, 2010 BACKGROUND: In inflammation and infection, cytochrome P450 (CYP) enzyme activities are down-regulated. Information on possible discrepancies in activities of CYP enzymes and drug transporters between HIV-infected patients and healthy people is limited ...
Doroshyenko, O +10 more
core +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.The study discovered that the Drug Stigma Scale is a valid tool to measure pharmacists' stigmatized attitudes toward people who use over‐the‐counter drugs for unintentional purposes. We encourage further studies to apply the scale to gain better knowledge and to counteract the stigma toward people who use OTC drugs.
Munenori Katayama +9 more
wiley +1 more source
Journal of Mazandaran University of Medical Sciences, 2019 Background and purpose: Postoperative pain management would result in increased patient’s satisfaction and decreases their problems. This survey was performed to determine the efficacy of premedication with dextromethorphan and gabapentin alone or in ...
Said Reza Entezari +3 more
doaj
Pharmacological and neurophysiological aspects of space/motion sickness [PDF]
A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the ...
Crampton, George H., Lucot, James B.
core +1 more source
مقايسه سه پيش داروی خوراکی دکسترومتورفان، ديفن هيدرامين و ميدازولام در معاينه چشم کودکان زير بيهوشی [PDF]
, 2011 زمينه و هدف: روندهای قبل از جراحی و بيهوشی و جداسازی کودک از والدين به منظور انجام اعمال بيهوشی و جراحی از مشکلات مهم و رايج در بيهوشی کودکان به شمار می رود.
ایمانی, فرناد +3 more
core
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Risperidone, an atypical antipsychotic, is increasingly prescribed in pediatric patients with psychiatric disorders. It is primarily metabolized by CYP2D6 to 9‐hydroxyrisperidone, an active metabolite associated with a higher risk of adverse effects.
Matthew H. Bennett +6 more
wiley +1 more source
Cold Pain Threshold and Role of NMDA Receptor Antagonists
Acta Medica Iranica, 2019 Clonidine, the α2-adrenergic agonist, is usually used as an antihypertensive drug. Dextromethorphan is a non-competitive NMDA antagonist which is routinely prescribed to suppress cough.
Poroshat Nazemi +9 more
doaj
Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study [PDF]
, 2007 Cytochrome P450 2D6 (CYP2D6) is one of the most important cytochromes P450 in humans. Resonance Raman data from the T309V mutant of CYP2D6 show that the substitution of the conserved I-helix threonine situated in the enzyme's active site perturbs the ...
Alois Bonifacio +62 more
core +2 more sources