Results 61 to 70 of about 9,214 (193)
Potentiation of the antidepressant-like effects of dextromethorphan by quinidine.
, 2014 A single dose of the CYP2D6 inhibitor quinidine (30 mg/kg, i.p.) administered concomitantly with dextromethorphan (0–30 mg/kg, i.p.) significantly potentiated the decrease in immobility time for dextromethorphan at 10 mg/kg (A).
Anna L. Scandinaro (529242) +4 more
core +1 more source
Mapping Trofinetide Polypharmacology in Rett Syndrome: A Multi‐Stage Computational Analysis
Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.How can a single molecule address the complex symptoms of Rett syndrome? This computational study maps the multi‐target mechanism of trofinetide, revealing diverse modes of binding across five key receptors: GAT1, GABAA, CHRM1, AMPA, and GSK3β. From deep orthosteric anchoring to dynamic surface interactions, these structural insights provide a rational
Luis Felipe Hernández‐Ayala +2 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 465-474, August 2026.Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur +4 more
wiley +1 more source
, 2014 A wide range of drugs is being abused by teenagers across the world, and over the years, they seem to have made the discovery that they could get "high " by taking over-the-counter medicines containing dextromethorphan (DXM).
Dextromethorphan Abuse
core
Journal of Mazandaran University of Medical Sciences, 2019 Background and purpose: Postoperative pain management would result in increased patient’s satisfaction and decreases their problems. This survey was performed to determine the efficacy of premedication with dextromethorphan and gabapentin alone or in ...
Said Reza Entezari +3 more
doaj
Cold Pain Threshold and Role of NMDA Receptor Antagonists
Acta Medica Iranica, 2019 Clonidine, the α2-adrenergic agonist, is usually used as an antihypertensive drug. Dextromethorphan is a non-competitive NMDA antagonist which is routinely prescribed to suppress cough.
Poroshat Nazemi +9 more
doaj
Journal of Islamic Dental Association of Iran, 2016 Background and Aim: Researchers have been in search of medications with less side effects to relieve pain after root canal therapy. This study aimed to assess the efficacy of premedication with oral dextromethorphan and Ibuprofen to decrease pain after ...
Maryam Zare Jahromi, Elmira Ahmadpour
doaj
Neuroprotective effects of SMADs in a rat model of cerebral ischemia/reperfusion
Neural Regeneration Research, 2015 Previous studies have shown that up-regulation of transforming growth factor β1 results in neuroprotective effects. However, the role of the transforming growth factor β1 downstream molecule, SMAD2/3, following ischemia/reperfusion remains unclear. Here,
Fang-fang Liu +6 more
doaj +1 more source
Canadian Medical Association Journal, 2014 Tony, Antoniou, David N, Juurlink
openaire +2 more sources