Results 21 to 30 of about 9,444 (165)

Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit

Pain Research and Management, 2016
Objective. Pain control is an essential goal in the management of critical children. Narcotics are the mainstay for pain control. Patients frequently need escalating doses of narcotics.
Mohammed Naeem, Hala Al Alem, Ali Al Shehri, Majed Al-Jeraisy   +3 more
doaj   +1 more source

Knowledge, attitude, and the practice of community pharmacists to dispense opioid-related and opioid-containing medication in Eastern Province, Saudi Arabia

Journal of Pharmacy and Bioallied Sciences, 2023
Objectives: This study was done to evaluate the knowledge of community pharmacists—working in Saudi Arabia—regarding over-the-counter opioid-related and opioid-containing medications.
Mohammad D Ali, Fatimah E Al Mubarak, Sherihan A Ghosn, Ayaz Ahmad, Sara H Alhussini, Sara F Almozien, Ghadeer A Alowaywi, Banin H Albeladi   +7 more
doaj   +1 more source

Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs

Journal of Pharmacological Sciences, 2011
.: Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its ...
Eun-Joo Shin, Jae-Hyung Bach, Sung Youl Lee, Jeong Min Kim, Jinhwa Lee, Jau-Shyong Hong, Toshitaka Nabeshima, Hyoung-Chun Kim   +7 more
doaj   +1 more source

Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine

Behavioural Neurology, 2021
Prenatal exposure to buprenorphine renders offspring vulnerable to cerebral impairments. In this study, our data demonstrate, for the first time, that prenatal exposure to buprenorphine escalates astrocyte activation concurrent with indications of ...
Chun-Hua Lin, Pao-Luh Tao, Huey-Jen Tsay, Yao-Chang Chiang, Wei-Tang Chang, Ing-Kang Ho, Feng-Shiun Shie   +6 more
doaj   +1 more source

Dextromethorphan in the treatment of early myoclonic encephalopathy evolving into migrating partial seizures in infancy

, 2014
Epileptic encephalopathy with suppression-burst in electroencephalography (EEG) can evolve into a few types of epileptic syndromes. We present here an unusual case of early myoclonic encephalopathy that evolved into migrating partial seizures in infancy.
Chien, Yin-Hsuan;Lin, Ming-I;Weng, Wen-Chin;Du, Jung-Chieh;Lee, Wang-Tso, 李旺祚 ;翁妏謹   +1 more
core   +1 more source

SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile

Frontiers in Pharmacology
BackgroundEsketamine, the first Food and Drug Administration-approved fast-acting antidepressant, has limited use because of its addictive properties.
Ying Xiao, Xuefeng Hu, Wei Xing, Jie Yan, Ruhuan Wang, Xiaoqing Li, Jiahuan Li, Zhixin Zhang, Jingchao Sun, Junjun Wu   +9 more
doaj   +1 more source

Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability

, 2022
Aryl-methyl ethers, while present in many bioactive compounds, are subject to rapid O-dealkylation, which can generate bioinactive or toxic metabolites.
Ryan A. Altman (1328814), Jacob P. Sorrentino (8629530), Ryan A. Altman, Jacob P. Sorrentino   +3 more
core   +1 more source

Crystal structures of bis[(9S,13S,14S)-3-methoxy-17-methylmorphinanium] tetrachloridocobaltate and tetrachloridocuprate

Acta Crystallographica Section E: Crystallographic Communications, 2017
(9S,13S,14S)-3-Methoxy-17-methylmorphinan (dextromethorphan) forms two isostructural salts with (a) tetrachloridocobaltate, namely bis[(9S,13S,14S)-3-methoxy-17-methylmorphinanium] tetrachloridocobaltate, (C18H26NO)2[CoCl4], and (b) tetrachloridocuprate,
Eric Gauchat, Alexander Y. Nazarenko
doaj   +1 more source

Competitive antagonism of the behavioral effects of dextromethorphan by BD1063.

, 2014
A single dose of BD1063 (10 mg/kg, i.p.) pretreatment shifted the dextromethorphan (0–50 mg/kg, i.p.) dose response curve to the right in the forced swim test (A), and blocked the dextromethorphan-induced stimulatory effect in the locomotor study (B ...
Anna L. Scandinaro (529242), Jason R. Healy (529241), Linda Nguyen (195959), Rae R. Matsumoto (529243), Matthew J. Robson (529240)   +4 more
core   +1 more source

Comparison of the Effects of Preemptive Gabapentin and Dextromethorphan on the Postoperative Pain after Open Prostatectomy [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2009
Background and Objectives: Preemptive administration of gabapentin and dextromethorphan has been shown to be effective for reduction of postoperative pain; but the effect of these two drugs has not yet been compared.
M.R. Mohaghegh, B. Kavand
doaj   +2 more sources