Results 21 to 30 of about 13,931 (178)

Intravenous ketamine for subacute treatment of refractory chronic migraine: a case series. [PDF]

, 2016
BACKGROUND: Refractory migraine is a challenging condition with great impact on health related quality of life. Intravenous (IV) ketamine has been previously used to treat various refractory pain conditions.
Ashina, Sait, Lauritsen, Clinton, Lipton, Richard B., Mazuera, Santiago   +3 more
core   +3 more sources

Dextromethorphan Dampens Neonatal Astrocyte Activation and Endoplasmic Reticulum Stress Induced by Prenatal Exposure to Buprenorphine

Behavioural Neurology, 2021
Prenatal exposure to buprenorphine renders offspring vulnerable to cerebral impairments. In this study, our data demonstrate, for the first time, that prenatal exposure to buprenorphine escalates astrocyte activation concurrent with indications of ...
Chun-Hua Lin, Pao-Luh Tao, Huey-Jen Tsay, Yao-Chang Chiang, Wei-Tang Chang, Ing-Kang Ho, Feng-Shiun Shie   +6 more
doaj   +1 more source

Knowledge, attitude, and the practice of community pharmacists to dispense opioid-related and opioid-containing medication in Eastern Province, Saudi Arabia

Journal of Pharmacy and Bioallied Sciences, 2023
Objectives: This study was done to evaluate the knowledge of community pharmacists—working in Saudi Arabia—regarding over-the-counter opioid-related and opioid-containing medications.
Mohammad D Ali, Fatimah E Al Mubarak, Sherihan A Ghosn, Ayaz Ahmad, Sara H Alhussini, Sara F Almozien, Ghadeer A Alowaywi, Banin H Albeladi   +7 more
doaj   +1 more source

Effect of N-Methyl-D-Aspartate Receptor Antagonist Dextromethorphan on Opioid Analgesia in Pediatric Intensive Care Unit

Pain Research and Management, 2016
Objective. Pain control is an essential goal in the management of critical children. Narcotics are the mainstay for pain control. Patients frequently need escalating doses of narcotics.
Mohammed Naeem, Hala Al Alem, Ali Al Shehri, Majed Al-Jeraisy   +3 more
doaj   +1 more source

Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs

Journal of Pharmacological Sciences, 2011
.: Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its ...
Eun-Joo Shin, Jae-Hyung Bach, Sung Youl Lee, Jeong Min Kim, Jinhwa Lee, Jau-Shyong Hong, Toshitaka Nabeshima, Hyoung-Chun Kim   +7 more
doaj   +1 more source

Combined NMDA Inhibitor Use in a Patient With Multisubstance-induced Psychotic Disorder [PDF]

, 2018
This document is an Accepted Manuscript reprinted from Journal of Addiction Medicine, Vol. 12 (3): 247-251, May 2018, with permission of Kluwer Law International. Under embargo until 1 May 2019.
Calabrò, Giuseppa, Caloro, Matteo, de Pisa, Eleonora, Girardi, Paolo, Kotzalidis, Georgios D, Locatelli, Carlo Alessandro, Lonati, Davide, Papa, Pietro, Rosini, Enrico, Schifano, Fabrizio   +9 more
core   +2 more sources

Botulinum toxin for the treatment of lower limb cramp pain in patients with Amyotrophic Lateral Sclerosis [PDF]

, 2020
Background: Muscle cramps and pain associated with them can be seen in patients with amyotrophic lateral sclerosis (ALS) and are known to reduce the quality of life. Pharmacological treatment may not benefit all patients in treating these cramps.
Govindarajan, Raghav, Mehta, Tejas, Sommers, Richard   +2 more
core   +2 more sources

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans. [PDF]

Clin Pharmacol Ther
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Aurinsalo L, Lapatto-Reiniluoto O, Kurkela M, Neuvonen M, Moilanen E, Niemi M, Tornio A, Backman JT.   +7 more
europepmc   +2 more sources

SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile

Frontiers in Pharmacology
BackgroundEsketamine, the first Food and Drug Administration-approved fast-acting antidepressant, has limited use because of its addictive properties.
Ying Xiao, Xuefeng Hu, Wei Xing, Jie Yan, Ruhuan Wang, Xiaoqing Li, Jiahuan Li, Zhixin Zhang, Jingchao Sun, Junjun Wu   +9 more
doaj   +1 more source

Sub-cellular sequestration of alkaline drugs in lysosomes: new insights for pharmaceutical development of lysosomal fluid

Research in Pharmaceutical Sciences, 2023
Background and purpose: Lysosomal-targeted drug delivery can open a new strategy for drug therapy. However, there is currently no universally accepted simulated or artificial lysosomal fluid utilized in the pharmaceutical industry or recognized by the ...
Malaz Yousef, Tyson S Le, Jieyu Zuo, Chulhun Park, Nadia Bou Chacra, Neal M Davies, Raimar Löbenberg   +6 more
doaj   +1 more source