Results 11 to 20 of about 9,444 (165)

Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction. [PDF]

PLoS ONE, 2014
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved
Jasbir D Upadhyaya, Nisha Singh, Anurag S Sikarwar, Raja Chakraborty, Sai P Pydi, Rajinder P Bhullar, Shyamala Dakshinamurti, Prashen Chelikani   +7 more
doaj   +2 more sources

Dextromethorphan abuse among opioid-dependent patients [PDF]

, 2020
BACKGROUND Among opioid-dependent patients on maintenance therapy, concomitant drug abuse is a serious problem. Dextromethorphan, an over-the-counter antitussive agent that can be purchased without prescription, is a drug with a high potential for ...
Seifritz, Erich, Hulka, Lea M, Gastberger, Salome, Baumgartner, Markus R, Windhab, Laura G, Müller, Thomas J, Soyka, Michael, Mutschler, Jochen, Soyka, Michael; https://orcid.org/, Hulka LM, Baumgartner, Markus R; https://orcid.org/, Windhab LG, Soyka M, Gastberger S, Baumgartner MR, Mutschler J, Müller TJ, Seifritz E   +17 more
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Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability [PDF]

, 2021
Aryl-methyl ethers, while present in many bioactive compounds, are subject to rapid O-dealkylation that can generate bio-inactive or toxic metabolites. As an example, the cough suppressant dextromethorphan undergoes such a P450 mediated O-dealkylation to
Ryan, Altman, Jacob, Sorrentino
core   +2 more sources

Dextromethorphan/Bupropion: First Approval

, 2022
Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the ...
Susan Keam (4873372)
core   +1 more source

Dextromethorphan withdrawal and dependence syndrome [PDF]

, 2010
Background: The N-methyl-D-aspartate (NMDA) antagonist dextromethorphan has been available in pharmacies without a prescription since 1954 as an antitussive agent. There is an alarming increase in reports of its abuse.
Martin Grosshans, Falk Kiefer, Koopmann, A, Derik Hermann, Karl Mann, Mann, K, Kiefer, F, Jochen Mutschler, Mutschler, J, Hermann, D, Anne Koopmann, Grosshans, M   +11 more
core   +1 more source

Dextromethorphan Abuse Among Adolescents [PDF]

, 2012
Dextromethorphan abuse has been increasing among adolescents over the past several years. This medication is readily available and socially accepted among peers.
Dunham, Lisa Ann
core   +2 more sources

The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via σ 1 receptor activation: Comparison with the effects of dextromethorphan

, 2020
In a previous study, we demonstrated that a dextromethorphan analog, dimemorfan, has neuroprotective effects. Dextromethorphan and dimemorfan are high-affinity ligands at σ 1 receptors.
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core   +1 more source

Pre-emptive oral dexmethorphan reduces fentanyl-induced cough as well as immediate postoperative adrenocortico-tropic hormone and growth hormone level

Journal of Anaesthesiology Clinical Pharmacology, 2011
Background : Fentanyl-induced cough is not always benign and brief and can be remarkably troublesome, spasmodic, and explosive. Dextromethorphan, an opioid derivative with an antitussive action, may be effective in reducing the fentanyl-induced cough ...
Avik Mukherjee, Asim Kumar Kundu, Sudipta Ghosh, Rajat Choudhuri, Bijoy Kumar Bandopadhyay, Sugata Dasgupta   +5 more
doaj   +1 more source

A retrospective analysis of cases of intentional dextromethorphan intoxication in the Department of Paediatrics and Gastroenterology of the Medical University of Lublin between 2008 and 2017

Pediatria i Medycyna Rodzinna, 2019
Aim: The aim of the study was to retrospectively assess cases of intentional dextromethorphan intoxication which were the reason for admissions to the Department of Paediatrics and Gastroenterology at the Medical University of Lublin between 2008 and ...
Karol Krawiec, Elżbieta Pac-Kożuchowska   +1 more
doaj   +1 more source

Enhanced biological degradation of Dextromethorphan and real pharmaceutical wastewater followed by reverse osmosis membrane [PDF]

Research Journal of Applied Biotechnology, 2018
Biological degradation of pharmaceutical wastewater followed by reverse osmosis (RO) membrane technology was investigated. The Membrane separation of Dextromethorphan was performed in a continuous mode operation.
Ayman Sawan, Medhat Hashem, Ibrahim Mousa, Nashwa Rizk, Reda Nassef   +4 more
doaj   +1 more source