Results 11 to 20 of about 9,214 (193)

Demographic characteristics and psychosocial backgrounds of patients with dextromethorphan overdose in Japan: A multicenter prospective observational study [PDF]

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim Few studies in Japan have described young patients presenting to emergency departments after dextromethorphan overdose in detail. Therefore, we aimed to investigate the demographic characteristics and psychosocial backgrounds of patients who presented to emergency departments in Japan after dextromethorphan overdose.
Hironori Katsuki, Yoshito Kamijo, Michiko Takai, Saeko Kohara, Hidetada Fukushima, Yuta Mizuno, Hidenobu Ochiai, Norio Otani, Dai Taguchi, Takuya Shimane, Ryoko Kyan   +10 more
wiley   +2 more sources

Evaluation of the Effect of Cendakimab on the Pharmacokinetics of CYP Probe Drugs in Patients With Eosinophilic Esophagitis [PDF]

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Cendakimab is a humanized monoclonal antibody that inhibits interleukin‐13 binding to its receptors. Although not expected to share clearance pathways with small molecules, its use in eosinophilic esophagitis, a type 2 inflammatory disease, may indirectly affect cytochrome P450 activity by modulating cytokine signaling affecting certain ...
Peijin Zhang, Christina M. Charriez, Bindu Murthy, Shenita Basdeo, Yanying Wang, Leonel Villa‐Caballero, Hamza Kandoussi, Claudia H. M. C. De Oliveira, David A. Leiman, Jie Li, Urvi Aras   +10 more
wiley   +2 more sources

SAL0114: a novel deuterated dextromethorphan-bupropion combination with improved antidepressant efficacy and safety profile [PDF]

Frontiers in Pharmacology
BackgroundEsketamine, the first Food and Drug Administration-approved fast-acting antidepressant, has limited use because of its addictive properties.
Ying Xiao, Xuefeng Hu, Wei Xing, Jie Yan, Ruhuan Wang, Xiaoqing Li, Jiahuan Li, Zhixin Zhang, Jingchao Sun, Junjun Wu   +9 more
doaj   +2 more sources

High‐Throughput Multi‐Capillary Electrophoresis [PDF]

ELECTROPHORESIS, Volume 47, Issue 9, Page 919-923, September 2026.
Multi‐capillary electrophoresis enables high‐throughput pharmaceutical analysis through simultaneous multi‐capillary operation, achieving a five‐fold reduction in run time per sample with improved sensitivity and linearity. Method transfer from single‐capillary systems is straightforward, supporting rapid and accurate quantification across diverse ...
Jana Drewes, Sarah Meyer, Isobel Roberts, Cleo Fanny, Philip A. Doble, Dayanne Mozaner Bordin, Janice I. McCauley   +6 more
wiley   +2 more sources

Dextromethorphan-bupropion combination in depression with dual diagnosis: Insights from a case series [PDF]

Indian Journal of Psychiatry
Background: Major depressive disorder and co-morbid substance use disorder represent a challenging dual diagnosis, characterized by persistent anhedonia, high relapse rates, and poor response to conventional antidepressants.
Mahak Aggarwal, Jawahar Singh, Khushpreet Kaur, Mohit Thakur, Rohit Guleria   +4 more
doaj   +2 more sources

A Staged Translational Framework for Evaluating Oral Glutamatergic and Senescence-Modulating Strategies in Treatment-Resistant Depression [PDF]

Drug Design, Development and Therapy
Ngo CheungCheung Ngo Medical Limited, Hong Kong SAR, People’s Republic of ChinaCorrespondence: Ngo Cheung, Cheung Ngo Medical Limited, Hong Kong SAR, People’s Republic of China, Tel +852 9876 8323, Email info@cheungngomedical.comAbstract: Treatment ...
Cheung N
doaj   +2 more sources

Dextromethorphan Abuse Among Opioid-Dependent Patients [PDF]

, 2020
BACKGROUND Among opioid-dependent patients on maintenance therapy, concomitant drug abuse is a serious problem. Dextromethorphan, an over-the-counter antitussive agent that can be purchased without prescription, is a drug with a high potential for ...
Seifritz, Erich, Erich Seifritz, Hulka, Lea M, Gastberger, Salome, Baumgartner, Markus R, Michael Soyka, Jochen Mutschler, Windhab, Laura G, Müller, Thomas J, Soyka, Michael, Lea M. Hulka, Mutschler, Jochen, Thomas J. Müller, Salome Gastberger, Markus R. Baumgartner, Laura G. Windhab   +15 more
core   +5 more sources

Fluoroalkylation of Dextromethorphan Improves CNS Exposure and Metabolic Stability [PDF]

, 2021
Aryl-methyl ethers, while present in many bioactive compounds, are subject to rapid O-dealkylation that can generate bio-inactive or toxic metabolites. As an example, the cough suppressant dextromethorphan undergoes such a P450 mediated O-dealkylation to
Ryan, Altman, Jacob, Sorrentino
core   +2 more sources

Dextromethorphan/Bupropion: First Approval

, 2022
Declarations Funding The preparation of this review was not supported by any external funding. Authorship and Conflict of interest During the peer review process the manufacturer of the agent under review was offered an opportunity to comment on the ...
Susan Keam (4873372)
core   +1 more source

Dextromethorphan and codeine: comparison of plasma kinetics and antitussive effects

, 1984
Plasma kinetics of dextromethorphan (as dextrorphan ) and codeine were investigated after acute oral doses in 8 patients with pathological cough; after which the patients participated in an acute dose-response study of the antitussive effects of each ...
Maddock, J., Davies, D. E., Aylward, Mansel, Protheroe, D. A., Leideman, T.   +4 more
core   +6 more sources