Results 11 to 20 of about 13,931 (178)

Efficacy of Dextromethorphan Augmentation in SSRI‐Resistant Obsessive–Compulsive Disorder: A Randomized Controlled Trial

Health Science Reports
Background and Aims Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance.
Ahmad Zolghadriha, Afagh Anjomshoaa, Romina Bagheri   +2 more
doaj   +2 more sources

Akathisia Induced by Metoclopramide in a Pregnant Woman With Nausea and Vomiting: A Case Report. [PDF]

Neuropsychopharmacol Rep
This case report describes a patient who was hospitalized at 33 weeks of gestation and diagnosed with metoclopramide‐induced akathisia. Although the akathisia symptoms resolved 3 days after discontinuation of metoclopramide, a possible interaction with dextromethorphan, which the patient had been orally administering prior to hospitalization, cannot be
Nakamura R, Noto K, Shirata T, Saito Y, Takehara I, Nagase S, Suzuki A.   +6 more
europepmc   +2 more sources

Effects of Cedirogant on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates. [PDF]

Clin Pharmacol Drug Dev
Abstract This study aimed to characterize the effects of cedirogant, an inverse agonist of retinoic acid–related orphan receptor gamma thymus (RORγt), on activities of cytochrome P450 (CYP) enzymes in healthy adults. Twenty study participants received a single oral dose of the modified Cooperstown 5+1 cocktail CYP probe drugs alone without cedirogant ...
D'Cunha R, Qian Y, Hao S, Eccleston J, Levy GF, Gannu S, Rizzo DG, Liu W, Mohamed MF.   +8 more
europepmc   +2 more sources

Clinical Characteristics of Over-The-Counter Drug Misusers in Psychiatric Practice in Japan: Comparison Between Codeine Misusers and Dextromethorphan Misusers. [PDF]

Neuropsychopharmacol Rep
In Japan, DXM abuse among young women has become a significant public health issue. ABSTRACT Purpose In recent years, the misuse of over‐the‐counter (OTC) medications has been increasing in psychiatric clinical settings in Japan. This study aimed to compare individuals who misuse codeine (COD) with those who misuse dextromethorphan (DXM) to clarify the
Tanibuchi Y, Omiya S, Usami T, Shimane T, Matsumoto T.   +4 more
europepmc   +2 more sources

Neuropsychotoxicity of Abused Drugs: Potential of Dextromethorphan and Novel Neuroprotective Analogs of Dextromethorphan With Improved Safety Profiles in Terms of Abuse and Neuroprotective Effects

Journal of Pharmacological Sciences, 2008
Drug abuse involving dextromethorphan, an antitussive, has been a social problem in various geographic locations since the 1960s. Ironically, high doses of the drug confer neuroprotective activity with central nervous system and behavioral effects ...
Eun-Joo Shin, Phil Ho Lee, Hyun Ji Kim, Toshitaka Nabeshima, Hyoung-Chun Kim   +4 more
doaj   +1 more source

Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction. [PDF]

PLoS ONE, 2014
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved
Jasbir D Upadhyaya, Nisha Singh, Anurag S Sikarwar, Raja Chakraborty, Sai P Pydi, Rajinder P Bhullar, Shyamala Dakshinamurti, Prashen Chelikani   +7 more
doaj   +1 more source

Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]

, 2019
Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska, De Clerck, Laura, Deforce, Dieter, Devreese, Mathias, Govaert, Elisabeth, Millecam, Joske, Schelstraete, Wim, Van Bocxlaer, Jan   +7 more
core   +1 more source

Pre-emptive oral dexmethorphan reduces fentanyl-induced cough as well as immediate postoperative adrenocortico-tropic hormone and growth hormone level

Journal of Anaesthesiology Clinical Pharmacology, 2011
Background : Fentanyl-induced cough is not always benign and brief and can be remarkably troublesome, spasmodic, and explosive. Dextromethorphan, an opioid derivative with an antitussive action, may be effective in reducing the fentanyl-induced cough ...
Avik Mukherjee, Asim Kumar Kundu, Sudipta Ghosh, Rajat Choudhuri, Bijoy Kumar Bandopadhyay, Sugata Dasgupta   +5 more
doaj   +1 more source

Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences [PDF]

, 2015
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions ...
Horie, Toshiharu, Oga, Enoche Florence, Sekine, Shuichi, Shitara, Yoshihisa   +3 more
core   +1 more source

A retrospective analysis of cases of intentional dextromethorphan intoxication in the Department of Paediatrics and Gastroenterology of the Medical University of Lublin between 2008 and 2017

Pediatria i Medycyna Rodzinna, 2019
Aim: The aim of the study was to retrospectively assess cases of intentional dextromethorphan intoxication which were the reason for admissions to the Department of Paediatrics and Gastroenterology at the Medical University of Lublin between 2008 and ...
Karol Krawiec, Elżbieta Pac-Kożuchowska   +1 more
doaj   +1 more source