Results 131 to 140 of about 2,363 (167)
Some of the next articles are maybe not open access.
Effect of DMSO and DFMO on rat prostate tumor growth
The Prostate, 1989AbstractAn anaplastic, metastatic subline of the Dunning rat tumor was exposed to non‐cytodestructive doses of the cellular differentiation agents dimethylsulfoxide and difluoromethylornithine. Copenhagen rats hosting prostate tumors were evaluated by comparing solid tumor growth resulting from injection of treated cells with solid tumor growth of ...
L, Carvalho, K, Foulkes, D D, Mickey
openaire +2 more sources
Sensitivity of Trypanosomatid Protozoa to DFMO and Metabolic Turnover of Ornithine Decarboxylase
Biochemical and Biophysical Research Communications, 2000alpha-Difluoromethylornithine (DFMO), the specific and irreversible inhibitor of ornithine decarboxylase (ODC), was able to induce the arrest of proliferation in Leishmania mexicana and ODC-transformed Trypanosoma cruzi cultures grown in a semi-defined medium essentially free of polyamines.
Carolina Carrillo +2 more
exaly +3 more sources
International Journal of Radiation Oncology Biology Physics, 2001
To report the results of a prospective Phase III trial for patients with newly diagnosed glioblastoma multiforme (GBM), treated with either accelerated hyperfractionated irradiation with or without difluromethylornithine (DFMO) or standard fractionated irradiation with or without DFMO.Adult patients with newly diagnosed GBM were registered and ...
Michael Prados +2 more
exaly +3 more sources
To report the results of a prospective Phase III trial for patients with newly diagnosed glioblastoma multiforme (GBM), treated with either accelerated hyperfractionated irradiation with or without difluromethylornithine (DFMO) or standard fractionated irradiation with or without DFMO.Adult patients with newly diagnosed GBM were registered and ...
Michael Prados +2 more
exaly +3 more sources
Effect of difluoromethylornithine (DFMO) on NSAID-induced intestinal injury in rats
Digestive Diseases and Sciences, 1992Combination therapy with difluoromethylornithine (DFMO) and a nonsteroidal antiinflammatory drug (NSAID) has been proposed for the chemoprevention of colonic neoplasia. The purpose of this study was to examine whether DFMO would affect NSAID-mediated intestinal injury.
R A, Erickson, N, Rivera
openaire +2 more sources
Combination treatment of TRAIL, DFMO and radiation for malignant glioma cells
Journal of Neuro-Oncology, 2015Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for cancer. Another promising cancer therapy is difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, which is oraly administered and well tolerated ...
George A Alexiou +2 more
exaly +3 more sources
Lytic infection of pseudorabies virus in the presence of spermine, spermidine, or DFMO
Virus Research, 2003The effects of polyamines (spermine or spermidine) and DFMO (an ornithine decarboxylase inhibitor) on the infection of LM (tk-) cells by pseudorabies virus (PRV) were investigated. Results from radioactive methionine labeling showed that the synthesis of viral proteins was not affected; however, the expression of a distinctive cellular protein ...
Hsien-Chi, Wang, Min-Liang, Wong
openaire +2 more sources
Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation
Bioorganic & Medicinal Chemistry Letters, 2012A series of potential DFMO prodrugs was designed through the incorporation of 4-nitrobenzyl ester or carbamate groups for potential activation by trypanosomal nitroreductase. It was found that only modification of N(ε)-amino group of DFMO by 4-nitro-2-fluorobenzyloxycarbonyl resulted in significant trypanocidal activity and could serve as a lead for ...
Yanhui, Yang +3 more
openaire +2 more sources
Effects of DFMO on glioma cell proliferation, migration and invasion in vitro
Journal of Neuro-Oncology, 1998The polyamine inhibitor DL-alpha-difluoromethylornithine (DFMO) is a specific irreversible inhibitor of ornithine decarboxylase which is a rate-limiting enzyme in the polyamine bio-synthesis pathway. The present study describes the effects of DFMO on glioma cell proliferation, migration and invasion using multicellular spheroids from three glioma cell ...
A J, Terzis +5 more
openaire +2 more sources
Cancer Prevention Research, 2011
Abstract Cultures of the human colon polyp cell line, VACO 235, were individually treated with DFMO, sulindac, and both DFMO and sulindac to determine the comparative effects of individual agent exposures and the combined agent exposure on gene expression and pathway modifications.
Eugene Elmore +2 more
openaire +1 more source
Abstract Cultures of the human colon polyp cell line, VACO 235, were individually treated with DFMO, sulindac, and both DFMO and sulindac to determine the comparative effects of individual agent exposures and the combined agent exposure on gene expression and pathway modifications.
Eugene Elmore +2 more
openaire +1 more source
Effects of eflornithine hydrochloride (DFMO) on fetal development in rats and rabbits
Teratology, 1989AbstractEflornithine hydrochloride (DFMO) is a highly selective, enzyme‐activated, irreversible inhibitor of the enzyme L‐ornithine decarboxylase (ODC). Because of its role in the biosynthetic pathway of polyamines, ODC is essential for the growth and development of newly implanted embryonic tissue. In order to assess its effect on embryonic growth and
B A, O'Toole, K W, Huffman, J P, Gibson
openaire +2 more sources