Results 151 to 160 of about 3,690 (206)

Spermine suppresses <i>Salmonella</i>-induced macrophage innate immune responses via inhibition of the cGAS-STING and TLR4 pathways. [PDF]

mBio
Wang X, Liu M, Qu X, Hou J, Chen S, Chang T, Li J, Xia J, Shen X, Wang Y, Xu L.   +10 more
europepmc   +1 more source

Eflornithine for the Chemoprevention of Luminal Gastrointestinal Neoplasms: A Systematic Review. [PDF]

Gastroenterology Res
Godoy A, Montalvan-Sanchez D, Principe-Meneses FS, Riva-Moscoso A, Sierra L, Erazo G, Avila C, Ramirez-Rojas M, Giron R, Guifarro DA.   +9 more
europepmc   +1 more source

Glycolysis maintains effector function of lung Th17 TRM cells in precision cut lung slices. [PDF]

iScience
Yang H, Kumaran VR, Song K, Remcho TP, Clark RDE, Thakur S, Lu S, Harrison MAA, Iwanaga N, Garcia-Hernandez ML, Rangel-Moreno J, Zwezdaryk KJ, McCombs JE, Norton EB, Kolls JK.   +14 more
europepmc   +1 more source

Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing. [PDF]

Am J Physiol Gastrointest Liver Physiol
Cairns CA, Chen T, Han N, Chen H, Chung HK, Xiao L, Wang JY.   +6 more
europepmc   +1 more source

Polyamines stimulate the protein synthesis of the translation initiation factor eIF5A2, participating in mRNA decoding, distinct from eIF5A1. [PDF]

J Biol Chem
Suzuki M, Suzuki T, Nakano Y, Matsumoto K, Manaka H, Komeno M, Tamori S, Sato A, Dohmae N, Akimoto K, Miyazaki S, Suda T, Toida T, Kashiwagi K, Igarashi K, Higashi K.   +15 more
europepmc   +1 more source

Eflornithine for neuroblastoma. [PDF]

Aust Prescr
europepmc   +1 more source

Polyamine Inhibition With DFMO: Shifting the Paradigm in Neuroblastoma Therapy

Journal of Clinical Medicine
Neuroblastoma is a common childhood malignancy, and high-risk presentations, including an MYCN amplified status, continue to result in poor survival. Difluoromethylornithine (DFMO) is a new and well-tolerated treatment for high-risk neuroblastoma.
Giselle S Sholler, Joseph Schramm
exaly   +4 more sources

Maintenance DFMO Increases Survival in High Risk Neuroblastoma [PDF]

Scientific Reports, 2018
High risk neuroblastoma (HRNB) accounts for 15% of all pediatric cancer deaths. Despite aggressive therapy approximately half of patients will relapse, typically with only transient responses to second-line therapy.
Peter E Zage, Don Eslin, Deanna Mitchell
exaly   +8 more sources

Chemoprevention of Prostate Carcinogenesis by DFMO And/Or Finasteride Treatment in Male Wistar Rats

Tumori, 2002
In the present study the chemopreventive activities of DFMO, the irreversible inhibitor of ornithine decarboxylase, and finasteride, the inhibitor of prostatic 5a-reductase, against the development of chemically induced prostate adenocarcinoma by ...
Amr Esmat, Mahmoud M Said, Fawzia M Refaie   +2 more
exaly   +4 more sources

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Polyamines Prevent DFMO-Mediated Inhibition of Angiogenesis

Cancer Letters, 1994
Tumor growth mainly depend on formation of new blood vessels. DFMO (alpha-difluoromethylornithine), an inhibitor of polyamine biosynthesis, inhibits tumor growth in many animal tumors. Our investigation was to evaluate the requirement of polyamines for induction of angiogenesis by tumor cells and spleen lymphocytes from tumor-bearing mice.
Martin Monte, Israel D. Algranati, I D Algranati   +2 more
exaly   +4 more sources