Results 161 to 170 of about 3,690 (206)
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Chemoprevention in Prostate Cancer: The Role of Difluoromethylornithine (DFMO)
Journal of Cellular Biochemistry, 1992The polyamines are normal cell constituents considered to have an important role in the regulation of proliferation and differentiation. DFMO is an irreversible, enzyme-activated, suicide inhibitor of ornithine decarboxylase (ODC), the enzyme responsible for the first and rate-limiting step in mammalian polyamine synthesis.
Dov Kadmon
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Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide
Life Sciences, 1993Mice given 1% alpha-difluoromethylornithine (DFMO) in the drinking water for 5 weeks developed a hyperactive behavior characterized by uncontrolled running upon stimulation with noise. The running was followed by seizures and sometimes death. These behaviors are characteristic of audiogenic seizures. Strain differences in susceptibility to DFMO-induced
K E, Gerrish +3 more
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Delayed, Reversible Hearing Loss Caused by Difluoromethylornithine (DFMO)
Laryngoscope, 2001AbstractObjectives/Hypothesis Difluoromethylornithine (DFMO) is an anticancer experimental drug that is ototoxic. The objectives of these three experiments were to: 1) determine a dose and dosing schedule of DFMO that produces significant hearing loss (HL) in newborn gerbils; 2) compare the HL level for control and newborn gerbils receiving daily ...
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Levels of Rectal Mucosal Polyamines and Prostaglandin E2 Predict Ability of DFMO and Sulindac to Prevent Colorectal Adenoma [PDF]
Gastroenterology, 2010 Background & Aims: Combination of polyamine and prostaglandin E2 (PGE2)synthesis inhibitors reduced the risk of colorectal adenoma (CRA) by 70% in patients who received polypectomies.
Bonnie J. LaFleur +2 more
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Effect of DMSO and DFMO on rat prostate tumor growth
The Prostate, 1989AbstractAn anaplastic, metastatic subline of the Dunning rat tumor was exposed to non‐cytodestructive doses of the cellular differentiation agents dimethylsulfoxide and difluoromethylornithine. Copenhagen rats hosting prostate tumors were evaluated by comparing solid tumor growth resulting from injection of treated cells with solid tumor growth of ...
L, Carvalho, K, Foulkes, D D, Mickey
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Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma
Cancer Chemotherapy and Pharmacology, 2021Neuroblastoma (NB) is the most common extracranial solid tumor in children. Interference with the polyamine biosynthesis pathway by inhibition of MYCN-activated ornithine decarboxylase (ODC) is a validated approach. The ODC inhibitor α-difluoromethylornithine (DFMO, or Eflornithine) has been FDA-approved for the treatment of trypanosomiasis and ...
Chad R. Schultz +3 more
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Sensitivity of Trypanosomatid Protozoa to DFMO and Metabolic Turnover of Ornithine Decarboxylase
Biochemical and Biophysical Research Communications, 2000alpha-Difluoromethylornithine (DFMO), the specific and irreversible inhibitor of ornithine decarboxylase (ODC), was able to induce the arrest of proliferation in Leishmania mexicana and ODC-transformed Trypanosoma cruzi cultures grown in a semi-defined medium essentially free of polyamines.
Carolina Carrillo +2 more
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Effects of DFMO on Glioma Cell Proliferation, Migration and Invasion in Vitro
Journal of Neuro-Oncology, 1998The polyamine inhibitor DL-alpha-difluoromethylornithine (DFMO) is a specific irreversible inhibitor of ornithine decarboxylase which is a rate-limiting enzyme in the polyamine bio-synthesis pathway. The present study describes the effects of DFMO on glioma cell proliferation, migration and invasion using multicellular spheroids from three glioma cell ...
Burt Feuerstein +2 more
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Effect of difluoromethylornithine (DFMO) on NSAID-induced intestinal injury in rats
Digestive Diseases and Sciences, 1992Combination therapy with difluoromethylornithine (DFMO) and a nonsteroidal antiinflammatory drug (NSAID) has been proposed for the chemoprevention of colonic neoplasia. The purpose of this study was to examine whether DFMO would affect NSAID-mediated intestinal injury.
R A, Erickson, N, Rivera
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Lytic infection of pseudorabies virus in the presence of spermine, spermidine, or DFMO
Virus Research, 2003The effects of polyamines (spermine or spermidine) and DFMO (an ornithine decarboxylase inhibitor) on the infection of LM (tk-) cells by pseudorabies virus (PRV) were investigated. Results from radioactive methionine labeling showed that the synthesis of viral proteins was not affected; however, the expression of a distinctive cellular protein ...
Hsien-Chi, Wang, Min-Liang, Wong
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