Results 171 to 180 of about 3,690 (206)
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Combination treatment of TRAIL, DFMO and radiation for malignant glioma cells
Journal of Neuro-Oncology, 2015Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown potent and cancer-selective killing activity and drawn considerable attention as a promising therapy for cancer. Another promising cancer therapy is difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, which is oraly administered and well tolerated ...
George A, Alexiou +8 more
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Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation
Bioorganic & Medicinal Chemistry Letters, 2012A series of potential DFMO prodrugs was designed through the incorporation of 4-nitrobenzyl ester or carbamate groups for potential activation by trypanosomal nitroreductase. It was found that only modification of N(ε)-amino group of DFMO by 4-nitro-2-fluorobenzyloxycarbonyl resulted in significant trypanocidal activity and could serve as a lead for ...
Yanhui, Yang +3 more
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Cancer Prevention Research, 2011
Abstract Cultures of the human colon polyp cell line, VACO 235, were individually treated with DFMO, sulindac, and both DFMO and sulindac to determine the comparative effects of individual agent exposures and the combined agent exposure on gene expression and pathway modifications.
Eugene Elmore +2 more
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Abstract Cultures of the human colon polyp cell line, VACO 235, were individually treated with DFMO, sulindac, and both DFMO and sulindac to determine the comparative effects of individual agent exposures and the combined agent exposure on gene expression and pathway modifications.
Eugene Elmore +2 more
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Effects of eflornithine hydrochloride (DFMO) on fetal development in rats and rabbits
Teratology, 1989AbstractEflornithine hydrochloride (DFMO) is a highly selective, enzyme‐activated, irreversible inhibitor of the enzyme L‐ornithine decarboxylase (ODC). Because of its role in the biosynthetic pathway of polyamines, ODC is essential for the growth and development of newly implanted embryonic tissue. In order to assess its effect on embryonic growth and
B A, O'Toole, K W, Huffman, J P, Gibson
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Combination treatment for glioblastoma with temozolomide, DFMO and radiation.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2019Glioblastoma multiforme (GBM) is the most malignant primary brain tumor with dismal prognosis. This tumor is characterized by extensive heterogeneity, thus is difficult to treat and every established or new treatment faces significant hazard of resistance. Temozolomide (TMZ), an oral alkylating agent, is the first-line treatment for GBM, but resistance
George, Alexiou +10 more
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Effects of Starvation and Difluoromethylornithine (DFMO) on Diamine Oxidase Activity in Rat Ileum
Digestion, 2009Starvation and difluoromethylornithine (DFMO) administration have profound affects on intestinal proliferation, ornithine decarboxylase activity, and tissue polyamine levels. Diamine oxidase activity may play a role in the regulation of proliferation, and the activity of this enzyme may be influenced by ornithine decarboxylase activity. To determine if
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Difluoromethylomithine (DFMO), an inhibitor of nitrite production by macrophages?
Biochemical Society Transactions, 1994openaire +2 more sources
METHODS TO TREAT CANCER WITH AMXT 1501 AND DFMO
2023BURNS MARK R, SKAGGS JAMES
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Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma
Case Medical Research, 2020openaire +1 more source