Diacylglycerol-mediated insulin resistance [PDF]
Nature Medicine, 2010 Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to explain insulin resistance, and, most recently, inflammation associated with alterations in adipocytokines has become the prevailing hypothesis.
Derek M, Erion, Gerald I, Shulman
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The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols [PDF]
Biochemical Journal, 1992 When ram spermatozoa were treated with Ca2+ and the ionophore A23187 to induce acrosomal exocytosis, a rise in diacylglycerol (DAG) mass was observed, concomitant with a rapid breakdown of [32P]P1-labelled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate and a rise in [32P]Pi-labelled phosphatidate. Inclusion of the DAG lipase
E R, Roldan, R A, Harrison
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Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol [PDF]
FEBS Letters, 2015 Diacylglycerol kinase (DGK) η plays important roles in various patho‐physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The K m value for diacylglycerol was 0.14 mol%.
Komenoi, Suguru +3 more
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SAP-Mediated Inhibition of Diacylglycerol Kinase α Regulates TCR-Induced Diacylglycerol Signaling [PDF]
The Journal of Immunology, 2011 Abstract Diacylglycerol kinases (DGKs) metabolize diacylglycerol to phosphatidic acid. In T lymphocytes, DGKα acts as a negative regulator of TCR signaling by decreasing diacylglycerol levels and inducing anergy. In this study, we show that upon costimulation of the TCR with CD28 or signaling lymphocyte activation molecule (SLAM), DGKα ...
Baldanzi, G. +19 more
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Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse
Molecular Biology of the Cell, 2011 Diacylglycerol (DAG) generation at the T cell immunological synapse (IS) determines the correct activation of antigen-specific immune responses. DAG kinases (DGKs) α and ζ act as negative regulators of DAG-mediated signals by catalyzing DAG conversion to phosphatidic acid (PA). Nonetheless, the specific input of each enzyme and their spatial regulation
Gharbi, Severine I. +7 more
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Editorial: Diacylglycerol Kinase Signalling [PDF]
Frontiers in Cell and Developmental Biology, 2017 Isabel Merida +3 more
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Diacylglycerol Kinase Signalling
, 2017 Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phosphatidic acid (PA). This reaction attenuates membrane DG levels, limiting the localization/activation of signaling proteins that bind this lipid. Initially recognized as modulators of classical and novel PKC family members, the function of the DGK has ...
Andrea Graziani +2 more
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Altered endocannabinoid system gene expression in inflammatory bowel disease mucosa: New perspectives in inflammatory bowel disease management. [PDF]
World J Gastrointest EndoscPelisenco IA +8 more
europepmc +1 more source
Disruption of Hepatic Insulin Signaling Causes Phospholipid Dysregulation in Mice. [PDF]
FASEB JPan Q +6 more
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Cannabidiolic acid as a modulator of lipid metabolism in the liver of rats with metabolic-associated steatotic liver disease. [PDF]
Sci RepKurzyna PF +8 more
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