Results 1 to 10 of about 115,506 (337)

DIP2 is a unique regulator of diacylglycerol lipid homeostasis in eukaryotes

eLife, 2022
Chain-length-specific subsets of diacylglycerol (DAG) lipids are proposed to regulate differential physiological responses ranging from signal transduction to modulation of the membrane properties.
Sudipta Mondal, Priyadarshan Kinatukara, Shubham Singh, Sakshi Shambhavi, Gajanan S Patil, Noopur Dubey, Salam Herojeet Singh, Biswajit Pal, P Chandra Shekar, Siddhesh S Kamat, Rajan Sankaranarayanan   +10 more
doaj   +1 more source

Effect of Diacylglycerol Crystallization on W/O/W Emulsion Stability, Controlled Release Properties and In Vitro Digestibility

Foods, 2023
Water-in-oil-in-water (W/O/W) emulsions with high-melting diacylglycerol (DAG) crystals incorporated in the oil droplets were fabricated and the compositions were optimized to achieve the best physical stability.
Chaoying Qiu, Yingwei Liu, Canfeng Chen, Yee Ying Lee, Yong Wang   +4 more
doaj   +1 more source

A review of phosphatidate phosphatase assays

Journal of Lipid Research, 2020
Phosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol and regulates the synthesis of membrane phospholipids.
Prabuddha Dey, Gil-Soo Han, George M. Carman   +2 more
doaj   +1 more source

Comparative membrane lipidomics of hepatocellular carcinoma cells reveals diacylglycerol and ceramide as key regulators of Wnt/β‐catenin signaling and tumor growth

Molecular Oncology, 2023
Hepatocellular carcinoma (HCC) is largely associated with aberrant activation of Wnt/β‐catenin signaling. Nevertheless, how membrane lipid composition is altered in HCC cells with abnormal Wnt signaling remains elusive.
Yagmur Azbazdar, Yeliz Demirci, Guillaume Heger, Dogac Ipekgil, Mustafa Karabicici, Gunes Ozhan   +5 more
doaj   +1 more source

Fermentative Production of Diacylglycerol by Endophytic Fungi Screened from Taxus chinensis var. mairei

Foods, 2023
Diacylglycerol (DAG) production by microbial fermentation has broad development prospects. In the present study, five endophytic fungi which could accumulate DAG were screened from Taxus chinensis var. mairei by using potato dextrose agar plate and flask
Wenqiang Xu, Haoran Bi, Hong Peng, Ling Yang, Hongwei He, Guiming Fu, Yuhuan Liu, Yin Wan   +7 more
doaj   +1 more source

Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain

BMC Neuroscience, 2008
Background Major depression is a serious mood disorder affecting millions of adults and children worldwide. While the etiopathology of depression remains obscure, antidepressant medications increase synaptic levels of monoamine neurotransmitters in brain
Undieh Ashiwel S, Vongtau Habiba OU, Tyeryar Kimberly R   +2 more
doaj   +1 more source

Perilipin 3 promotes the formation of membrane domains enriched in diacylglycerol and lipid droplet biogenesis proteins

Frontiers in Cell and Developmental Biology, 2023
Lipid droplets (LDs) serve as intracellular stores of energy-rich neutral lipids. LDs form at discrete sites in the endoplasmic reticulum (ER) and they remain closely associated with the ER during lipogenic growth and lipolytic consumption.
Rasha Khaddaj, Jiri Stribny, Stéphanie Cottier, Roger Schneiter   +3 more
doaj   +1 more source

A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters

Journal of Lipid Research, 2005
Acyl-CoA-dependent O-acyltransferases catalyze reactions in which fatty acyl-CoAs are joined to acyl acceptors containing free hydroxyl groups to produce neutral lipids.
Chi-Liang Eric Yen, Charles H. Brown, IV, Mara Monetti, Robert V. Farese, Jr.   +3 more
doaj   +1 more source

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

Cell Reports, 2017
Hepatic lipid accumulation has been implicated in the development of insulin resistance, but translational evidence in humans is limited. We investigated the relationship between liver fat and tissue-specific insulin sensitivity in 133 obese subjects ...
Kasper W. ter Horst, Pim W. Gilijamse, Ruth I. Versteeg, Mariette T. Ackermans, Aart J. Nederveen, Susanne E. la Fleur, Johannes A. Romijn, Max Nieuwdorp, Dongyan Zhang, Varman T. Samuel, Daniel F. Vatner, Kitt F. Petersen, Gerald I. Shulman, Mireille J. Serlie   +13 more
doaj   +1 more source

Fat-regulating phosphatidic acid phosphatase: a review of its roles and regulation in lipid homeostasis

Journal of Lipid Research, 2019
Phosphatidic acid (PA) phosphatase is an evolutionarily conserved enzyme that plays a major role in lipid homeostasis by controlling the cellular levels of its substrate, PA, and its product, diacylglycerol.
George M. Carman, Gil-Soo Han
doaj   +1 more source