Diallyl trisulfide induces pro-apoptotic autophagy via the AMPK/SIRT1 signalling pathway in human hepatocellular carcinoma HepG2 cell line [PDF]
Food & Nutrition Research, 2023 Background: Liver cancer is associated with a high mortality rate worldwide. Hepatocellular carcinoma (HCC) constitutes a large proportion of primary liver cancers, and most of its alterations currently remain untreatable.
Shuoshuo Sun +4 more
doaj +2 more sources
Diallyl trisulfide modulated autophagy in isoproterenol induced acute myocardial infarction
Clinical Phytoscience, 2022 Background Acute myocardial infarction (AMI) is the most serious manifestation of coronary artery disease. The initial ischemia in AMI causes biochemical and metabolic alterations in cardiomyocytes.
Nahla E. El-Ashmawy +3 more
doaj +2 more sources
Dietary Bioactive Diallyl Trisulfide in Cancer Prevention and Treatment. [PDF]
Int J Mol Sci, 2017 Bioactive dietary agents have been shown to regulate multiple cancer hallmark pathways. Epidemiologic studies have linked consumption of Allium vegetables, such as garlic and onions, to decreased incidence of cancer. Diallyl trisulfide (DATS), a bioactive compound derived from Allium vegetables, has been investigated as an anti-cancer and ...
Puccinelli MT, Stan SD.
europepmc +4 more sources
VALIDATION AND ANALYSIS OF DIALLYL DISULFIDE AND DIALLYL TRISULFIDE IN GARLIC (ALLIUM SATIVUM L.) USING GAS CHROMATOGRAPHY [PDF]
International Journal of Applied Pharmaceutics, 2020 Objective: The purpose of this research was to optimize and validate a method for measuring the levels of diallyl disulfide (DADS) and diallyl trisulfide(DATS) in garlic and single clove garlic.Methods: The analysis was performed using gas chromatography
HARMITA, HARMITA +2 more
core +5 more sources
Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role. [PDF]
Int J Mol Sci, 2020 This study aimed to examine the effects of diallyl trisulfide (DATS), the most potent polysulfide derived from garlic, on metabolic syndrome and myocardial function in rats with metabolic syndrome (MetS). For that purpose, we used 36 male Wistar albino rats divided into control rats, rats with MetS and MetS rats treated with 40 mg/kg of DATS every ...
Jeremic JN +11 more
europepmc +5 more sources
Effects of Diallyl Trisulfide, an Active Substance from Garlic Essential Oil, on Energy Metabolism in Male Moth Sitotroga cerealella (Olivier) [PDF]
Insects, 2020 This study investigated the effects of diallyl trisulfide (DAT), an active substance from garlic essential oil, on the metabolism of the main energy substances of pre- and postmating males of Sitotroga cerealella.
Meng-Ya Wu +8 more
doaj +2 more sources
Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics [PDF]
Prostate Cancer, 2016 Hydrogen sulfide (H2S) was originally considered toxic at elevated levels; however just in the past decade H2S has been proposed to be an important gasotransmitter with various physiological and pathophysiological roles in the body.
Mingzhe Liu +3 more
doaj +4 more sources
Diallyl Trisulfide Modulates Notch Pathway Components in Breast Cancer Cells [PDF]
, 2016 Breast cancer affects one in eight women throughout the course of their lifetimes creating an immediate demand for novel prevention strategies against this disease.
Kiesel, Violet
core +3 more sources
Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects. [PDF]
Adv Sci (Weinh)Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Tian H +16 more
europepmc +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Accumulating evidence suggests that hydrogen sulfide ( H2S ), an endogenously produced gaseous molecule, plays a critical role in the regulation of cardiovascular homeostasis. However, little is known about its role in lymphangiogenesis. Thus,
Junya Suzuki +10 more
doaj +1 more source