A concise enantioselective synthesis of the guaiane sesquiterpene (−)-oxyphyllol
Beilstein Journal of Organic Chemistry, 2013 (−)-Oxyphyllol was prepared in only 4 steps from an epoxy enone that already served as an intermediate for the total synthesis of the anticancer guaiane (−)-englerin A.
Martin Zahel, Peter Metz
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Ferrocene-derived P,N ligands : synthesis and application in enantioselective catalysis [PDF]
, 2013 Due to their unique steric and electronic properties, air-stability and modular structure, chiral hybrid P,N-ferrocenyl ligands play a prominent role in the field of asymmetric catalysis.
Noël, Timothy, Van der Eycken, Johan
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The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers
Beilstein Journal of Organic Chemistry, 2017 The diastereoselective synthesis of fluorinated building blocks that contain chiral fluorine substituents is of interest. Here we describe optimisation efforts in the synthesis of anti-2,3-difluorobutane-1,4-diol, as well as the synthesis of the ...
Robert Szpera +4 more
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Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]
, 2014 Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
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Preparation of 4 '-spirocyclobutyl nucleoside analogues as novel and versatile adenosine scaffolds
, 2019 Despite the large variety of modified nucleosides that have been reported, the preparation of constrained 4 '-spirocyclic adenosine analogues has received very little attention.
De Vleeschouwer, Freija +10 more
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Stereochemical aspects of the "tert-amino effect". 2. Enantio- and diastereoselectivity in the synthesis of quinolines, pyrrolo[1,2-a]quinolines, and [1,4]oxazino[4,3-a]quinolines [PDF]
, 1989 W. H. N. Nijhuis +4 more
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Diastereoselectivity in Photochemistry
Diastereoselective photochemical reactions play an important role for asymmetric synthesis, for example for the synthesis of natural or biologically active compounds. Chirality is either induced by a chiral auxiliary or by a chiral centers already present in the substrates.
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Molecules, 2017 A highly diastereoselective cyclopropanation of cyclic enones with sulfur ylides was developed under catalyst-free conditions, producing multifunctional spirocyclopropanes in generally excellent yields (up to 99% yield and >99:1 d.r.).
Yi Li +9 more
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Metal-free syn-dioxygenation of alkenes [PDF]
, 2013 Reactions employing inexpensive reagents from sustainable sources and with low toxicity are becoming increasingly desirable from an academic and industrial perspective.
Ashikari +60 more
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Diastereoselectivity and asymmetric induction in the Diels–Alder reaction of o-quinodimethanes [PDF]
, 1986 James L. Charlton
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